MABC954
MilliporeSigma™ Mouse anti-MUTYH, Clone: 12D5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC954-Each-of-1 | In Stock | ₹ 41,307.51 |
MABC954 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
MUTYH
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
MUTYH; MYH
Immunogen
GST-tagged recombinant internal fragment from the N-terminal half of human MUTYH.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_036354
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Western Blot
Clone
12D5.1
Gene Accession No.
Q9UIF7
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects MUTYH clone: 12D5.1 in Human samples, and it is validated for Western Blotting A/G-specific adenine DNA glycosylase (UniProt Q9UIF7; also known as hMYH, MutY homolog) is encoded by the MUTYH (also known as MYH) gene (Gene ID 4595) in human
- Base excision repair (BER) is initiated by damage-specific DNA glycosylases that recognize and remove aberrant bases by hydrolyzing the N-glycosidic bond, creating an apurinic/apyrimidinic (AP) site
- This is followed by an (AP)-endonuclease-catalyzed DNA strand incision 5′ to the AP site, trimming of the 5′ end by an (AP)-lyase or an endonuclease, DNA resynthesis by a DNA polymerase and strand sealing by a DNA ligase
- Monofunctional glycosylases have only glycosylase activity, whereas bifunctional glycosylases possess additional AP lyase activity and can therefore convert a base lesion into a single-strand break without the need for a separate AP endonuclease
- MUTYH/MYH is a monofunctional DNA glycosylase that excises mismatched adenine opposite 7, 8-dihydro-8-oxoguanine (8-oxoG), which is the major mutagenic lesion induced by oxidative stress
- Biallelic mutations in MUTYH are associated with MUTYH-Associated polyposis (MAP) and increased risk in colorectal cancer (CRC).
Compare Similar Items
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Antigen: MUTYH
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: MUTYH; MYH
Immunogen: GST-tagged recombinant internal fragment from the N-terminal half of human MUTYH.
Quantity: 100 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_036354
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot
Clone: 12D5.1
Gene Accession No.: Q9UIF7
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
MUTYH
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
MUTYH; MYH
Immunogen:
GST-tagged recombinant internal fragment from the N-terminal half of human MUTYH.
Quantity:
100 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_036354
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
12D5.1
Gene Accession No.:
Q9UIF7
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: __
Classification: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Isotype:
__
Applications:
__
Clone:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: CD1d
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG2aκ antibody in PBS without preservatives.
Gene Symbols: CD1d, Cd1d1
Immunogen: Rat CD1d-transduced M12.4.1.C3 cells.
Quantity: 100 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_058775
Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype: IgG2a κ
Applications: Functional Assay, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone: WTH-1
Gene Accession No.: Q63493
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Mouse, Rat
Form: Purified
Antigen:
CD1d
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG2aκ antibody in PBS without preservatives.
Gene Symbols:
CD1d, Cd1d1
Immunogen:
Rat CD1d-transduced M12.4.1.C3 cells.
Quantity:
100 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_058775
Content And Storage:
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype:
IgG2a κ
Applications:
Functional Assay, Flow Cytometry, Immunohistochemistry, Immunoprecipitation, Western Blot
Clone:
WTH-1
Gene Accession No.:
Q63493
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Mouse, Rat
Form:
Purified
Antigen: S1PR2/EDG5
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Gene Symbols: S1PR2, EDG5
Immunogen: GST-tagged recombinant protein corresponding to the cytoplasmic domain of human S1PR2/EDG5.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: 2-8°C for one year
Isotype: IgM κ
Applications: Immunohistochemistry, Western Blot
Clone: 6E8.1
Gene Accession No.: NP_004221
Host Species: Mouse
Purification Method: Purified by ion-exchange chromatography
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
S1PR2/EDG5
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgMκ in buffer containing PBS with 0.05% sodium azide.
Gene Symbols:
S1PR2, EDG5
Immunogen:
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human S1PR2/EDG5.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
2-8°C for one year
Isotype:
IgM κ
Applications:
Immunohistochemistry, Western Blot
Clone:
6E8.1
Gene Accession No.:
NP_004221
Host Species:
Mouse
Purification Method:
Purified by ion-exchange chromatography
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified