MABE967MI
MilliporeSigma™ anti-DNA polymerase delta p125 Clone: 11E10.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE967MI-Each-of-1 | In Stock | ₹ 42,677.33 |
MABE967MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,677.33
GST (18%): ₹ 7,681.919
Total Price: ₹ 50,359.249
Antigen
DNA polymerase delta p125
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P28340
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
11E10.1
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
POLD1, POLD
Immunogen
GST-tagged recombinant protein corresponding to the N-terminus of human DNA polymerase delta p125.
Quantity
100 μg
Research Discipline
Epigenetics, Nuclear Function
Gene ID (Entrez)
NP_001243778
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG2b κ
Related Products
Description
- Specifically detects DNA polymerase delta p125 Clone: 11E10.1 in Human samples, and it is validated for Western Blotting DNA polymerase delta catalytic subunit (EC 2.7.7.7; UniProt P28340; also known as CDC2 homolog, DNA polymerase subunit delta p125) is encoded by the POLD1 (also known as CDC2, MDPL, POLD, CRCS10) gene (Gene ID 5424) in human
- DNA replication in eukaryotes involves multiple enzymes including the B family polymerases Pol α, Pol δ, and Pol ?
- While Pol α initiates DNA synthesis, Pol δ and Pol ? replace Pol α after primer extension and perform the bulk of DNA replication
- Pol δ and Pol ? are heterotetramers in higher eukaryotes comprised of POLD1 and POLE as the respective catalytic subunit, as well as accessory subunits (POLD2/3/4 and POLE2/3/4) that interact with cofactors such as Proliferating Cell Nuclear Antigen (PCNA)
- Both POLD1 and POLE contain an exonuclease domain (a.a
- 268-471 of POLE and 304-517 of POLD1) that proof-reading capability during DNA replication
- In addition to DNA synthesis, Pol ? and Pol δ are believed to participate in chromosomal DNA repairs, including nucleotide excision repair (NER), ismatch repair (MMR) and repair of double strand breaks (DSBR)
- Germline exonuclease domain mutations (EDMs) in POLD1 and POLE cause polymerase proofreading-associated polyposis (PPAP)
- Tumors with EDMs exhibits dramatically increased base substitutions.
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Antigen: DNA polymerase delta p125
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P28340
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 11E10.1
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: POLD1, POLD
Immunogen: GST-tagged recombinant protein corresponding to the N-terminus of human DNA polymerase delta p125.
Quantity: 100 μg
Research Discipline: Epigenetics, Nuclear Function
Gene ID (Entrez): NP_001243778
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2b κ
Antigen:
DNA polymerase delta p125
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P28340
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
11E10.1
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
POLD1, POLD
Immunogen:
GST-tagged recombinant protein corresponding to the N-terminus of human DNA polymerase delta p125.
Quantity:
100 μg
Research Discipline:
Epigenetics, Nuclear Function
Gene ID (Entrez):
NP_001243778
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2b κ
Antigen: HLCS
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P50747
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 2C2.1
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: HLCS
Immunogen: GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000402
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2a κ
Antigen:
HLCS
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P50747
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
2C2.1
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
HLCS
Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000402
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2a κ
Antigen: HNF-1-beta
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P35680
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Rat
Form: Purified
Applications: Immunohistochemistry, Western Blot
Clone: 12A5.1
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: HNF1B, TCF2
Immunogen: GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human HNF-1-beta.
Quantity: 100 μg
Research Discipline: Epigenetics, Nuclear Function
Gene ID (Entrez): NP_000449
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2a κ
Antigen:
HNF-1-beta
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P35680
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Rat
Form:
Purified
Applications:
Immunohistochemistry, Western Blot
Clone:
12A5.1
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
HNF1B, TCF2
Immunogen:
GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human HNF-1-beta.
Quantity:
100 μg
Research Discipline:
Epigenetics, Nuclear Function
Gene ID (Entrez):
NP_000449
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2a κ
Antigen: PRDM5
Classification: Monoclonal
Conjugate: __
Gene Accession No.: Q9NQX1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Mouse
Form: Purified
Applications: Immunoprecipitation, Western Blot
Clone: 57-20
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PRDM5; PFM2
Immunogen: GST-tagged recombinant protein corresponding to human PRDM5 near the N-terminus.
Quantity: 200 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_061169
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
PRDM5
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
Q9NQX1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Mouse
Form:
Purified
Applications:
Immunoprecipitation, Western Blot
Clone:
57-20
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PRDM5; PFM2
Immunogen:
GST-tagged recombinant protein corresponding to human PRDM5 near the N-terminus.
Quantity:
200 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_061169
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ