MABE968MI

MilliporeSigma™ anti-HLCS Clone: 2C2.1,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABE968MI-Each-of-1 In Stock ₹ 38,734.72

MABE968MI - Each of 1

₹ 38,734.72

In Stock

Quantity

1

Base Price: ₹ 38,734.72

GST (18%): ₹ 6,972.25

Total Price: ₹ 45,706.97

Antigen

HLCS

Classification

Monoclonal

Conjugate

Unconjugated

Gene Accession No.

P50747

Host Species

Mouse

Purification Method

Protein G purified

Regulatory Status

RUO

Primary or Secondary

Primary

Target Species

Human

Form

Purified

Applications

Western Blot

Clone

2C2.1

Formulation

Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols

HLCS

Immunogen

GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.

Quantity

100 μg

Research Discipline

Signaling

Gene ID (Entrez)

NP_000402

Content And Storage

2°C to 8°C for one year from date of shipment

Isotype

IgG2a κ

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Description

  • Specifically detects HLCS Clone: 2C2.1 in Human samples, and it is validated for Western Blotting Biotin-protein ligase (EC 6.3.4.9; EC 6.3.4.10; EC 6.3.4.11; EC 6.3.4.15; UniProt P50747; also known as Biotin-[acetyl-CoA-carboxylase] ligase, Biotin apo-protein ligase, Biotin-[methylcrotonoyl-CoA-carboxylase] ligase, Biotin-[methylmalonyl-CoA-carboxytransferase] ligase, Biotin-[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase, HCS, Holocarboxylase synthetase) is encoded by the HLCS (also known as HCS) gene (Gene ID 3141) in human
  • HLCS (holocarboxylase synthetase) is the sole biotin protein ligase encoded by the human genome
  • HLCS catalyses the covalent modification of target lysine residues by biotin
  • In addiition to taregting various carboxylases in the cytoplasm and mitochondria, both the full-length HLCS and a splicing variant are reported to enter the nucleus and associate with multi-protein gene repression complex
  • HLCS overexpression in HEK293 cells is reported to downregulate histone H3 lysine9 acetylation (H3K9ac) level with a cocomitant drop in LTRs (long terminal repeats) 15 and 22 due to a decrease in mRNA coding for LTRs
  • HLCS is also reported to induce RANTES expression in HEK-293 cells by biotinylating heat shock protein 72 (HSP72).

Compare Similar Items

Show Difference

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MilliporeSigma™

MABE968MI

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Antigen:
HLCS

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene Accession No.:
P50747

Host Species:
Mouse

Purification Method:
Protein G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
2C2.1

Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:
HLCS

Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.

Quantity:
100 μg

Research Discipline:
Signaling

Gene ID (Entrez):
NP_000402

Content And Storage:
2°C to 8°C for one year from date of shipment

Isotype:
IgG2a κ

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MABE971MI

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Antigen:
HNF-1-beta

Classification:
Monoclonal

Conjugate:
Unconjugated

Gene Accession No.:
P35680

Host Species:
Mouse

Purification Method:
Protein G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human, Rat

Form:
Purified

Applications:
Immunohistochemistry, Western Blot

Clone:
12A5.1

Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:
HNF1B, TCF2

Immunogen:
GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human HNF-1-beta.

Quantity:
100 μg

Research Discipline:
Epigenetics, Nuclear Function

Gene ID (Entrez):
NP_000449

Content And Storage:
2°C to 8°C for one year from date of shipment

Isotype:
IgG2a κ

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MABE972MI

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Antigen:
PRDM5

Classification:
Monoclonal

Conjugate:
__

Gene Accession No.:
Q9NQX1

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Mouse

Form:
Purified

Applications:
Immunoprecipitation, Western Blot

Clone:
57-20

Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:
PRDM5; PFM2

Immunogen:
GST-tagged recombinant protein corresponding to human PRDM5 near the N-terminus.

Quantity:
200 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_061169

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG2b κ

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Antigen:
Ser/Thr-protein kinase Nek2

Classification:
Monoclonal

Conjugate:
__

Gene Accession No.:
P51955

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Target Species:
Human, Mouse

Form:
Purified

Applications:
Immunocytochemistry, Western Blot

Clone:
5D2.1

Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Symbols:
NEK2; NEK2A; NLK1

Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal of human Ser/Thr-protein kinase Nek2.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_002488

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG2b κ