MABE968MI
MilliporeSigma™ anti-HLCS Clone: 2C2.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE968MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABE968MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
HLCS
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P50747
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
2C2.1
Formulation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
HLCS
Immunogen
GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_000402
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG2a κ
Related Products
Description
- Specifically detects HLCS Clone: 2C2.1 in Human samples, and it is validated for Western Blotting Biotin-protein ligase (EC 6.3.4.9; EC 6.3.4.10; EC 6.3.4.11; EC 6.3.4.15; UniProt P50747; also known as Biotin-[acetyl-CoA-carboxylase] ligase, Biotin apo-protein ligase, Biotin-[methylcrotonoyl-CoA-carboxylase] ligase, Biotin-[methylmalonyl-CoA-carboxytransferase] ligase, Biotin-[propionyl-CoA-carboxylase [ATP-hydrolyzing]] ligase, HCS, Holocarboxylase synthetase) is encoded by the HLCS (also known as HCS) gene (Gene ID 3141) in human
- HLCS (holocarboxylase synthetase) is the sole biotin protein ligase encoded by the human genome
- HLCS catalyses the covalent modification of target lysine residues by biotin
- In addiition to taregting various carboxylases in the cytoplasm and mitochondria, both the full-length HLCS and a splicing variant are reported to enter the nucleus and associate with multi-protein gene repression complex
- HLCS overexpression in HEK293 cells is reported to downregulate histone H3 lysine9 acetylation (H3K9ac) level with a cocomitant drop in LTRs (long terminal repeats) 15 and 22 due to a decrease in mRNA coding for LTRs
- HLCS is also reported to induce RANTES expression in HEK-293 cells by biotinylating heat shock protein 72 (HSP72).
Compare Similar Items
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Antigen: HLCS
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P50747
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 2C2.1
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: HLCS
Immunogen: GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000402
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2a κ
Antigen:
HLCS
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P50747
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
2C2.1
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
HLCS
Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000402
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2a κ
Antigen: HNF-1-beta
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P35680
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Rat
Form: Purified
Applications: Immunohistochemistry, Western Blot
Clone: 12A5.1
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: HNF1B, TCF2
Immunogen: GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human HNF-1-beta.
Quantity: 100 μg
Research Discipline: Epigenetics, Nuclear Function
Gene ID (Entrez): NP_000449
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2a κ
Antigen:
HNF-1-beta
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P35680
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Rat
Form:
Purified
Applications:
Immunohistochemistry, Western Blot
Clone:
12A5.1
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
HNF1B, TCF2
Immunogen:
GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human HNF-1-beta.
Quantity:
100 μg
Research Discipline:
Epigenetics, Nuclear Function
Gene ID (Entrez):
NP_000449
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2a κ
Antigen: PRDM5
Classification: Monoclonal
Conjugate: __
Gene Accession No.: Q9NQX1
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Mouse
Form: Purified
Applications: Immunoprecipitation, Western Blot
Clone: 57-20
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PRDM5; PFM2
Immunogen: GST-tagged recombinant protein corresponding to human PRDM5 near the N-terminus.
Quantity: 200 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_061169
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
PRDM5
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
Q9NQX1
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Mouse
Form:
Purified
Applications:
Immunoprecipitation, Western Blot
Clone:
57-20
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PRDM5; PFM2
Immunogen:
GST-tagged recombinant protein corresponding to human PRDM5 near the N-terminus.
Quantity:
200 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_061169
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: Ser/Thr-protein kinase Nek2
Classification: Monoclonal
Conjugate: __
Gene Accession No.: P51955
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Applications: Immunocytochemistry, Western Blot
Clone: 5D2.1
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: NEK2; NEK2A; NLK1
Immunogen: GST-tagged recombinant protein corresponding to the N-terminal of human Ser/Thr-protein kinase Nek2.
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_002488
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
Ser/Thr-protein kinase Nek2
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
P51955
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunocytochemistry, Western Blot
Clone:
5D2.1
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
NEK2; NEK2A; NLK1
Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal of human Ser/Thr-protein kinase Nek2.
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_002488
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ