MABF935
MilliporeSigma™ Mouse anti-MPR300/IGF-2R/CD222, Clone: 2C2,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF935-Each-of-1 | In Stock | ₹ 39,063.27 |
MABF935 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,063.27
GST (18%): ₹ 7,031.389
Total Price: ₹ 46,094.659
Antigen
MPR300/IGF-2R/CD222
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in PBS without preservatives.
Gene Symbols
IGF2R; CIMPR; MPRI
Immunogen
Recombinant full-length human MPR300/IGF-2R/CD222.
Quantity
100 μg
Research Discipline
Inflammation and Immunology
Gene ID (Entrez)
NP_000867
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
2C2
Gene Accession No.
P11717
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects MPR300/IGF-2R/CD222 clone: 2C2 in Human samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Western Blotting Cation-independent mannose-6-phosphate receptor (UniProt P11717; also known as 300kDa mannose 6-phosphate receptor, CD222, CI Man-6-P receptor, CI-MPR, IGF-II receptor, Insulin-like growth factor 2 receptor, Insulin-like growth factor II receptor, M6P/IGF2 receptor, M6P/IGF2R, M6P-R, M6PR, MPR 300) is encoded by the IGF2R (also known as CIMPR, MPRI) gene (Gene ID 3482) in human
- Mannose 6-phosphate (M6P) receptors (MPRs) mediate the delivery of newly synthesized, mannose 6-phosphate-bound lysosomal hydrolases from the secretory pathway to the endosomal system
- MPRs bind lysosomal hydrolases in the trans-Golgi network (TGN) and unload the enzyme in the endosomal system
- There exist a cation-independent CI-MPR (IGF2R) and a smaller CD-MPR that requires divalent cations for lysosomal hydrolases recognition
- MPRs also undergo recycling between the endosomal system and the plasma membrane, where CI-MPR mediates the internalization of other ligands, including insulin-like growth factor II (IGF-II)
- CI-MPR/IGF2R is produced with a signal peptide (a.a
- 1-40), the removal of which yields the mature receptor with a large lumenal/extracellular region (a.a
- 41-2304), a transmembrane segment (a.a
- 2305-2327), and a cytoplasmic domain (a.a
- 2328-2491), The extracellular region is composed of 15 P-type carbohydrate recognition domains, also referred to as MRH (mannose 6-phosphate receptor homology) domains
- Domains 3 and 9 bind M6P with high affinity and domain 5 binds M6P with weak affinity, while domain 11 binds IGF-II.
Compare Similar Items
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Antigen: MPR300/IGF-2R/CD222
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in PBS without preservatives.
Gene Symbols: IGF2R; CIMPR; MPRI
Immunogen: Recombinant full-length human MPR300/IGF-2R/CD222.
Quantity: 100 μg
Research Discipline: Inflammation and Immunology
Gene ID (Entrez): NP_000867
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 2C2
Gene Accession No.: P11717
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
MPR300/IGF-2R/CD222
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in PBS without preservatives.
Gene Symbols:
IGF2R; CIMPR; MPRI
Immunogen:
Recombinant full-length human MPR300/IGF-2R/CD222.
Quantity:
100 μg
Research Discipline:
Inflammation and Immunology
Gene ID (Entrez):
NP_000867
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
2C2
Gene Accession No.:
P11717
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: Notch 3
Classification: Monoclonal
Formulation: Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: NOTCH3; CASIL; CADASIL; IMF2
Immunogen: KLH-conjugated linear peptide corresponding to a sequence from the EGF-like domains 33-34 region of human Notch 3 ECD.
Quantity: 100 μg
Research Discipline: Inflammation and Immunology
Gene ID (Entrez): NP_000426
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Clone: 2G8
Gene Accession No.: Q9UM47
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Notch 3
Classification:
Monoclonal
Formulation:
Purified rat monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
NOTCH3; CASIL; CADASIL; IMF2
Immunogen:
KLH-conjugated linear peptide corresponding to a sequence from the EGF-like domains 33-34 region of human Notch 3 ECD.
Quantity:
100 μg
Research Discipline:
Inflammation and Immunology
Gene ID (Entrez):
NP_000426
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Applications:
Immunofluorescence, Immunohistochemistry, Western Blot
Clone:
2G8
Gene Accession No.:
Q9UM47
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: __
Classification: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Isotype:
__
Applications:
__
Clone:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: IFNAR1
Classification: Monoclonal
Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: His-tagged recombinant human IFNAR1 extracellular domain.
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_000620
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: 4G8
Gene Accession No.: P17181
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
IFNAR1
Classification:
Monoclonal
Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
His-tagged recombinant human IFNAR1 extracellular domain.
Quantity:
100 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_000620
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
4G8
Gene Accession No.:
P17181
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified