MilliporeSigma™ IFNAR1, Mouse, Unlabeled, Clone: 4G8,

Description

• Interferon alpha/beta receptor 1 (UniProt P17181; also known as CRF2-1, Cytokine receptor class-II member 1, Cytokine receptor family 2 member 1, IFN-alpha/beta receptor 1, IFN-R-1, Type I interferon receptor 1) is encoded by the IFNAR1 (also known as IFNAR) gene (Gene ID 3454) in human
• Interferons (IFNs) are cytokines whose prouction and release by host cells are induced in the presence of pathogens (e.g
• viruses, bacteria, parasites) and tumor cells
• More than twenty distinct IFN genes and proteins have been identified and classified into three main types
• Type I IFNs (IFN-α, IFN-β, IFN-ε, IFN-κ, and IFN-ω) exert their function via binding IFN-α/β receptor (encoded by the IFNAR1 and IFNAR2 gene, respectively)
• Ligation of IFNAR by IFN-I results in activation of the Janus kinases, Jak1 and Tyk2, which in turn phosphorylates STAT1 and STAT2, resulting in recruitment of IRF9 to form the IFN-stimulated gene factor 3 (ISGF3) transcription factor
• ISGF3 then translocates to the nucleus, where it binds IFN-stimulated response elements (ISREs) and drives the transcription of IFN-stimulated genes (ISGs)
• IFNAR1 is phosphorylated by Tyk2 and PKD2 upon IFN-I stimulation, leading to IFNAR1 ubiquitination and lysosomal degradation
• IFNAR1 is also phosphorylated by p38 MAP kinase in response to non-IFN stimuli, including the PERK-dependent unfolded protein response (UPR), ligation of pattern recognition receptors (PRRs), or through signaling via other inflammatory cytokines or growth factors including VEGF, IL-1β and TNFα
• Encephalitic flaviviruses antagonize IFN-I signaling by inhibiting IFNAR1 surface expression, where the viral nonstructural protein 5 (NS5) targets cellular prolidase (PEPD) that is required for IFNAR1 maturation and accumulation.