MABS1250MI
MilliporeSigma™ Mouse anti-Mineralocorticoid Receptor, Clone: 2D6,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1250MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABS1250MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
Mineralocorticoid Receptor
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
Nr3c2; Mlr
Immunogen
Conjugated linear peptide corresponding to the N-terminus of rat Mineralocorticoid Receptor.
Quantity
200 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_037263
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2a κ
Applications
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone
2D6
Gene Accession No.
P22199
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Rat
Form
Purified
Related Products
Description
- Specifically detects Mineralocorticoid Receptor clone: 2D6 in Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry, Western Blotting Mineralocorticoid receptor (UniProt P22199; also known as MR, Nuclear receptor subfamily 3 group C member 2) is encoded by the Nr3c2 (also known as MCR, Mlr) gene (Gene ID 25672) in rats
- Mineralocorticoid receptor (MR) is expressed in multiple tissues, including renal epithelia, smooth muscle, endothelium, cardiomyocytes, and hippocampal neurons, where it mediates diverse functions
- MR is activated by aldosterone and also by cortisol in cells that do not express 11β-hydroxysteroid dehydrogenase type 2 (11βHSD2)
- MR is normally activated by aldosterone, which is produced by adrenal glomerulosa in response to intravascular volume depletion and hyperkalemia
- Consistently, gain of function mutations in MR lead to severe hypertension, often with hypokalemia, while loss of function mutations result in neonatal hypotension
- Ser843 phosphorylation in the MR ligand-binding domain is reported to prevent MR ligand binding and activation
- MR pS843 is found exclusively in intercalated cells of the distal nephrons in the kidney
- Intravascular volume depletion, angiotensin II and WNK4 signaling reduce MR pS843 levels, whereas hyperkalemia increases MR pS843.
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Antigen: Mineralocorticoid Receptor
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: Nr3c2; Mlr
Immunogen: Conjugated linear peptide corresponding to the N-terminus of rat Mineralocorticoid Receptor.
Quantity: 200 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_037263
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 2D6
Gene Accession No.: P22199
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Rat
Form: Purified
Antigen:
Mineralocorticoid Receptor
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
Nr3c2; Mlr
Immunogen:
Conjugated linear peptide corresponding to the N-terminus of rat Mineralocorticoid Receptor.
Quantity:
200 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_037263
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
2D6
Gene Accession No.:
P22199
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Rat
Form:
Purified
Antigen: CYP11B2
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: CYP11B2
Immunogen: Chicken serum albumin-conjugated linear peptide corresponding to human CYP11B2 near the N-terminus.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000489
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot
Clone: 41-17B
Gene Accession No.: P19099
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
CYP11B2
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
CYP11B2
Immunogen:
Chicken serum albumin-conjugated linear peptide corresponding to human CYP11B2 near the N-terminus.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000489
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
41-17B
Gene Accession No.:
P19099
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: Polycystin-1
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PKD1
Immunogen: FLAG-tagged recombinant human polycystin-1 C-type lectin domain.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001009944.2
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: E4 (5F4D2)
Gene Accession No.: P98161
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
Polycystin-1
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PKD1
Immunogen:
FLAG-tagged recombinant human polycystin-1 C-type lectin domain.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001009944.2
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
E4 (5F4D2)
Gene Accession No.:
P98161
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: O-GlcNAc
Classification: Monoclonal
Formulation: Purified mouse IgM in buffer containing PBS without preservatives.
Gene Symbols: __
Immunogen: Nuclear pore complex-lamina fraction isolated from rat liver nuclear envelopes.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze
Isotype: IgM κ
Applications: Immunoassay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone: RL1
Gene Accession No.: __
Host Species: Mouse
Purification Method: Purified by Ion-Exchange Chromatography
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Drosophila
Form: Purified
Antigen:
O-GlcNAc
Classification:
Monoclonal
Formulation:
Purified mouse IgM in buffer containing PBS without preservatives.
Gene Symbols:
__
Immunogen:
Nuclear pore complex-lamina fraction isolated from rat liver nuclear envelopes.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze
Isotype:
IgM κ
Applications:
Immunoassay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone:
RL1
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Purified by Ion-Exchange Chromatography
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Drosophila
Form:
Purified