MABS1252
MilliporeSigma™ Mouse anti-Polycystin-1, Clone: E4 (5F4D2),
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1252-Each-of-1 | In Stock | ₹ 39,063.27 |
MABS1252 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,063.27
GST (18%): ₹ 7,031.389
Total Price: ₹ 46,094.659
Antigen
Polycystin-1
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
PKD1
Immunogen
FLAG-tagged recombinant human polycystin-1 C-type lectin domain.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001009944.2
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone
E4 (5F4D2)
Gene Accession No.
P98161
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Purified
Related Products
Description
- Specifically detects Polycystin-1 clone: E4 (5F4D2) in Human, Mouse, Rat samples, and it is validated for Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blotting Polycystin-1 (UniProt P98161; also known as Autosomal dominant polycystic kidney disease 1 protein) is encoded by the PKD1 gene (Gene ID 5310) in human
- The primary cilium is a microtubule-based mechano- and chemo-sensory organelle that coordinates an array of cellular pathways during development and in tissue homeostasis, including Hedgehog (Hh), PDGFRα and Wnt signaling
- Defective ciliary function causes a variety of ciliopathies, including autosomal dominant polycystic kidney disease (ADPKD)
- Polycystin-1 (PC1) and polycystin-2 (PC2) are large transmembrane proteins co-localized to primary cilium, where they play an important role in calcium-based signalling
- PC1 is an atypical adhesion G-protein-coupled receptor (aGPCR) with 11-transmemrbane domains
- PC1 is cis-autoproteolytically cleaved at a juxtamembrane GPCR cleavage site (GPS; a.a
- 3012-3061) in a developmental stage-dependent manner, where PC1 is largely uncleaved in early embryonic kidneys but becomes extensively cleaved after birth
- GPS cleavage results in a heterodimeric PC1 form, in which the N-terminal fragment (NTF) remains non-covalently associated with the transmembrane C-terminal fragment (CTF)
- Transgenic mice expressing non-cleavable PC1 develop cystic kidney disease during the postnatal period.
Compare Similar Items
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Antigen: Polycystin-1
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PKD1
Immunogen: FLAG-tagged recombinant human polycystin-1 C-type lectin domain.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001009944.2
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone: E4 (5F4D2)
Gene Accession No.: P98161
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
Polycystin-1
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PKD1
Immunogen:
FLAG-tagged recombinant human polycystin-1 C-type lectin domain.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001009944.2
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot
Clone:
E4 (5F4D2)
Gene Accession No.:
P98161
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: O-GlcNAc
Classification: Monoclonal
Formulation: Purified mouse IgM in buffer containing PBS without preservatives.
Gene Symbols: __
Immunogen: Nuclear pore complex-lamina fraction isolated from rat liver nuclear envelopes.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze
Isotype: IgM κ
Applications: Immunoassay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone: RL1
Gene Accession No.: __
Host Species: Mouse
Purification Method: Purified by Ion-Exchange Chromatography
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Drosophila
Form: Purified
Antigen:
O-GlcNAc
Classification:
Monoclonal
Formulation:
Purified mouse IgM in buffer containing PBS without preservatives.
Gene Symbols:
__
Immunogen:
Nuclear pore complex-lamina fraction isolated from rat liver nuclear envelopes.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze
Isotype:
IgM κ
Applications:
Immunoassay, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, Immunoprecipitation, Inhibition Assays
Clone:
RL1
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Purified by Ion-Exchange Chromatography
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Drosophila
Form:
Purified
Antigen: __
Classification: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
__
Isotype:
__
Applications:
__
Clone:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Target Species:
__
Form:
__
Antigen: Platelet Factor 4
Classification: Monoclonal
Formulation: Purified mouse IgG1 in buffer containing PBS without preservatives.
Gene Symbols: __
Immunogen: Purified human platelet PF4 (Xiao, Z., et al. (2008). Blood. 112(4):1091-1100).
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_002610
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Applications: Flow Cytometry, Immunocytochemistry, Western Blot
Clone: 197.2
Gene Accession No.: P02776
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Platelet Factor 4
Classification:
Monoclonal
Formulation:
Purified mouse IgG1 in buffer containing PBS without preservatives.
Gene Symbols:
__
Immunogen:
Purified human platelet PF4 (Xiao, Z., et al. (2008). Blood. 112(4):1091-1100).
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_002610
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Applications:
Flow Cytometry, Immunocytochemistry, Western Blot
Clone:
197.2
Gene Accession No.:
P02776
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified