MABS478MI
MilliporeSigma™ Mouse anti-Nucleobindin-2, Clone: 11B3.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS478MI-Each-of-1 | In Stock | ₹ 37,825.00 |
MABS478MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,825.00
GST (18%): ₹ 6,808.50
Total Price: ₹ 44,633.50
Antigen
Nucleobindin-2
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
NUCB2; NEFA
Immunogen
GST-tagged recombinant protein corresponding to human Nucleobindin-2.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_005004
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
11B3.1
Gene Accession No.
P80303
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse, Rat
Form
Purified
Related Products
Description
- Specifically detects Nucleobindin-2 clone: 11B3.1 in Human, Mouse, Rat samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Nucleobindin-2 (UniProt P80303; also known as DNA-binding protein NEFA, Epididymis secretory protein Li 109, Gastric cancer antigen Zg4, Nucleobinding 2, Prepronefastin, Prepronesfatin) is encoded by the NUCB2 gene (also known as HEL-S-109, NEFA) (Gene ID 4925) in human
- Nucleobindin-2 is initially translated as a 420 aa precursor protein
- Cleavage of signal peptide (aa1-24) yields the 396 aa mature nucleobindin-2 with very high sequence homology among human, mouse, and rat species ( 85%)
- Post-translational processing by prohormone convertases (PC 1/3 and PC 2) cleaves nucleobindin-2 into nesfatin-1, nesfatin-2, and nesfatin-3 (aa1–82, aa85–163, and aa166–396, respectively, numbering based on mature sequence)
- Nesfatin-1 is a well recognized circulating anorexigenic peptide, whose production increases post-prandially
- Nucleobinin-2 contains two calcium-binding EF-hand domains separated by an acidic amino acid-rich region, and a leucine zipper
- NUCB2 is expressed in key hypothalamic nuclei and plays a role in energy homeostasis
- It is also expressed in various human peripheral tissues, including the stomach, pancreas, reproductive organs, and adipose tissue, suggesting its roles in various metabolic functions
- NUCB2 expression level is reported to be elevated in clear cell renal cell carcinoma (ccRCC), breast cancer, and prostate cancer (PCa) tissues.
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Antigen: Nucleobindin-2
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: NUCB2; NEFA
Immunogen: GST-tagged recombinant protein corresponding to human Nucleobindin-2.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_005004
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 11B3.1
Gene Accession No.: P80303
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
Nucleobindin-2
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
NUCB2; NEFA
Immunogen:
GST-tagged recombinant protein corresponding to human Nucleobindin-2.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_005004
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
11B3.1
Gene Accession No.:
P80303
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: PTPN22
Classification: Monoclonal
Formulation: Mouse monoclonal IgG1κ in supernatant without preservatives.
Gene Symbols: PTPN22, PTPN8
Immunogen: GST-tagged recombinant protein corresponding to the C-terminal of human PTPN22.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_057051
Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype: IgG1 κ
Applications: Western Blot
Clone: 3B3.1
Gene Accession No.: Q9Y2R2
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Supernatant
Antigen:
PTPN22
Classification:
Monoclonal
Formulation:
Mouse monoclonal IgG1κ in supernatant without preservatives.
Gene Symbols:
PTPN22, PTPN8
Immunogen:
GST-tagged recombinant protein corresponding to the C-terminal of human PTPN22.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_057051
Content And Storage:
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
3B3.1
Gene Accession No.:
Q9Y2R2
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Supernatant
Antigen: PL Scramblase 1
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PLSCR1
Immunogen: Recombinant protein corresponding to human PL Scramblase 1.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_066928
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Clone: 1A8
Gene Accession No.: O15162
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
PL Scramblase 1
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PLSCR1
Immunogen:
Recombinant protein corresponding to human PL Scramblase 1.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_066928
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Clone:
1A8
Gene Accession No.:
O15162
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
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