MABS480MI
MilliporeSigma™ anti-PTPN22 Clone: 3B3.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS480MI-Each-of-1 | In Stock | ₹ 45,381.02 |
MABS480MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 45,381.02
GST (18%): ₹ 8,168.584
Total Price: ₹ 53,549.604
Antigen
PTPN22
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q9Y2R2
Host Species
Mouse
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 3B3.1 is expected to react with spliced isoform 1 (LyP1), isoform 3, and isoform 4 (LyP3), but not isoform 2 (LyP2) or isoform 5. Reactivity toward isoform 6 (PTPN22.6) has not been tested.
Content And Storage
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype
IgG1 κ
Applications
Western Blot
Clone
3B3.1
Formulation
Mouse monoclonal IgG1κ in supernatant without preservatives.
Gene Symbols
PTPN22, PTPN8
Immunogen
GST-tagged recombinant protein corresponding to the C-terminal of human PTPN22.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_057051
Target Species
Human
Form
Supernatant
Related Products
Description
- Specifically detects PTPN22 Clone: 3B3.1 in Human samples, and it is validated for Western Blotting Tyrosine-protein phosphatase non-receptor type 22 (EC:3.1.3.48; UniProt Q9Y2R2; also known as Hematopoietic cell protein-tyrosine phosphatase 70Z-PEP, Lymphoid phosphatase, Lymphoid-specific protein tyrosine phosphatase, Lyp, PEP, PEST-domain phosphatase, Protein tyrosine phosphatase non-receptor type 8) is encoded by the PTPN22 (also known as LYP, LYP1, LYP2, PTPN8) gene (Gene ID 26191) in human
- PTPN22/Lyp is expressed in all hematopoietic cells and belongs to the PEST group of nonreceptor classical class I protein tyrosine phosphatases (PTPs)
- Lyp is a negative regulator of TCR signal transduction by targeting phosphorylated Lck (Y394), Fyn (Y427), and Zap-70, as well as phospho-sites on TCRζ, CD3ε, Vav, and Vcp
- Lyp utilizes its proline-rich region 1 to interact with the SH3 domain of C-terminal Src kinase (Csk), resulting in enhanced inhibitory tuning of Src family kinases and TCR signal transduction
- TRAF3 is also shown to bind the proline-rich region 1 of Lyp in myeloid cells and impact its turnover
- Additional binding partners of Lyp include the adaptor molecule Grb2, the E3 ligase c-Cbl.
Compare Similar Items
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Antigen: PTPN22
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: Q9Y2R2
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3B3.1 is expected to react with spliced isoform 1 (LyP1), isoform 3, and isoform 4 (LyP3), but not isoform 2 (LyP2) or isoform 5. Reactivity toward isoform 6 (PTPN22.6) has not been tested.
Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype: IgG1 κ
Applications: Western Blot
Clone: 3B3.1
Formulation: Mouse monoclonal IgG1κ in supernatant without preservatives.
Gene Symbols: PTPN22, PTPN8
Immunogen: GST-tagged recombinant protein corresponding to the C-terminal of human PTPN22.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_057051
Target Species: Human
Form: Supernatant
Antigen:
PTPN22
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
Q9Y2R2
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 3B3.1 is expected to react with spliced isoform 1 (LyP1), isoform 3, and isoform 4 (LyP3), but not isoform 2 (LyP2) or isoform 5. Reactivity toward isoform 6 (PTPN22.6) has not been tested.
Content And Storage:
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
3B3.1
Formulation:
Mouse monoclonal IgG1κ in supernatant without preservatives.
Gene Symbols:
PTPN22, PTPN8
Immunogen:
GST-tagged recombinant protein corresponding to the C-terminal of human PTPN22.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_057051
Target Species:
Human
Form:
Supernatant
Antigen: PL Scramblase 1
Classification: Monoclonal
Conjugate: __
Gene Accession No.: O15162
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Applications: Immunohistochemistry, Immunoprecipitation, Western Blot
Clone: 1A8
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PLSCR1
Immunogen: Recombinant protein corresponding to human PL Scramblase 1.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_066928
Target Species: Human, Mouse
Form: Purified
Antigen:
PL Scramblase 1
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
O15162
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ
Applications:
Immunohistochemistry, Immunoprecipitation, Western Blot
Clone:
1A8
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PLSCR1
Immunogen:
Recombinant protein corresponding to human PL Scramblase 1.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_066928
Target Species:
Human, Mouse
Form:
Purified
Antigen: __
Classification: __
Conjugate: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Applications:
__
Clone:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Antigen: Ido1
Classification: Monoclonal
Conjugate: __
Gene Accession No.: P14902
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Applications: Flow Cytometry, Western Blot
Clone: 8G11
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: IDO1; IDO; INDO
Immunogen: Recombinant protein corresponding to mouse Ido1.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_002155
Target Species: Mouse
Form: Purified
Antigen:
Ido1
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
P14902
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Applications:
Flow Cytometry, Western Blot
Clone:
8G11
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
IDO1; IDO; INDO
Immunogen:
Recombinant protein corresponding to mouse Ido1.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_002155
Target Species:
Mouse
Form:
Purified