MABS489MI
MilliporeSigma™ anti-LRP-2/Megalin Clone: 10D5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS489MI-Each-of-1 | In Stock | ₹ 40,486.99 |
MABS489MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,486.99
GST (18%): ₹ 7,287.658
Total Price: ₹ 47,774.648
Antigen
LRP-2/Megalin
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P98164
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
10D5.1
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
LRP2, DBS
Immunogen
GST-tagged recombinant protein corresponding to the LDL-receptor class A repeats 19-21 of human LRP-2/Megalin.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_004516
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Related Products
Description
- Specifically detects LRP-2/Megalin Clone: 10D5.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Low-density lipoprotein receptor-related protein 2 (UniProt P98164; also known as Calcium sensor protein, Glycoprotein 330, gp330, Heymann nephritis antigen homolog, LRP-2, Megalin) is encoded by the LRP2 (also known as DBS) gene (Gene ID 4036) in human
- Megalin/LRP-2 is a 600kDa type I membrane receptor initially produced with a signal peptide sequence (a.a
- 1-25)
- The mature receptor has a large extracellular region (a.a
- 26-4423), a transmembrane segment (a.a
- 4424-4446), and cytoplasmic tail (a.a
- 4447-4655)
- Megalin belongs to the LDLR family of membrane glycoproteins whose members also inculde the low-density lipoprotein receptor (LDLR), the very-low-density lipoprotein (VLDL) receptor, the LDLR-related protein (LRP), and the apolipoprotein E receptor 2 (ApoER2)
- The overall extracellular structural features are similar among all LDLR family members
- Megalin contains four clusters of cysteine-rich Complement-type/LDLR Class A repeats that mediate ligand-binding
- These are separated by 17 EGF-like repeats and eight cysteine-poor spacer regions that contain YWTD motifs involved in the pH-dependent ligands dissociation in endosomal compartments
- Megalin is a multiligand, endocytic receptor expressed primarily in the apical membranes of polarized epithelial cells
- In addtion to functioning alone, megalin is also reported to interact with another structurally distinct endocytic receptor cubilin in several tissues where they are co-expressed
- The internalization of several cubilin ligands is reported to be strongly facilitated in the presence of megalin.
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Antigen: LRP-2/Megalin
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P98164
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 10D5.1
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: LRP2, DBS
Immunogen: GST-tagged recombinant protein corresponding to the LDL-receptor class A repeats 19-21 of human LRP-2/Megalin.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_004516
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Antigen:
LRP-2/Megalin
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P98164
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
10D5.1
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
LRP2, DBS
Immunogen:
GST-tagged recombinant protein corresponding to the LDL-receptor class A repeats 19-21 of human LRP-2/Megalin.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_004516
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ
Antigen: Cytochrome P450 26B1
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: Q9NR63
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 4B7.2
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: GST-tagged recombinant internal fragment from the C-terminal half of human Cytochrome P450 26B1.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_063938
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Cytochrome P450 26B1
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
Q9NR63
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
4B7.2
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
GST-tagged recombinant internal fragment from the C-terminal half of human Cytochrome P450 26B1.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_063938
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Anoctamin-5
Classification: Monoclonal
Conjugate: __
Gene Accession No.: Q75V66
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: __
Applications: Western Blot
Clone: 5F7
Formulation: Mouse monoclonal IgMκ in buffer containing supernatant without preservatives.
Gene Symbols: ANO5; GDD1; TMEM16E
Immunogen: Linear peptide corresponding to mouse Anoctamin-5 near the C-terminus.
Quantity: 200 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_998764
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype: IgM κ
Antigen:
Anoctamin-5
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
Q75V66
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
__
Applications:
Western Blot
Clone:
5F7
Formulation:
Mouse monoclonal IgMκ in buffer containing supernatant without preservatives.
Gene Symbols:
ANO5; GDD1; TMEM16E
Immunogen:
Linear peptide corresponding to mouse Anoctamin-5 near the C-terminus.
Quantity:
200 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_998764
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype:
IgM κ
Antigen: GOT1
Classification: Monoclonal
Conjugate: __
Gene Accession No.: P17174
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 1F5.2
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: GOT1
Immunogen: GST-tagged Recombinant protein corresponding to the N-terminal region of human GOT1.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_002070
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
GOT1
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
P17174
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
1F5.2
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
GOT1
Immunogen:
GST-tagged Recombinant protein corresponding to the N-terminal region of human GOT1.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_002070
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ