MABT328MI
MilliporeSigma™ anti-Siglec-1 (CD169) Clone: 5F1.1,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABT328MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABT328MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
Siglec-1 (CD169)
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q9BZZ2
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with all three spliced isoforms of human Siglec-1 (CD169)/Sialoadhesin reported by UniProt (Q9BZZ2).
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG2a κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
5F1.1
Formulation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
SIGLEC1, SN
Immunogen
GST-tagged recombinant human Siglec-1 (CD169) N-terminal fragment containing the Ig-like V-type domain.
Quantity
100 μg
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_075556
Target Species
Human, Mouse
Form
Purified
Related Products
Description
- Specifically detects Siglec-1 (CD169) Clone: 5F1.1 in Human, Mouse samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Sialoadhesin (UniProt Q9BZZ2; also known as CD169, Sialic acid-binding Ig-like lectin 1, Sialic acid-binding immunoglobulin-like lectin 1, Siglec-1) is encoded by the SIGLEC1 (also known as SN) gene (Gene ID 6614) in human
- Sialoadhesin/CD169/Siglec-1 is the founding member of the sialic acid-binding immunoglobulin lectins (Siglec) expressed on a variety of leukocytes and stromal cells
- Sialoadhesin is initially produced with a signal sequence (a.a
- 1-19), the removal of which yields the mature protein with a large extracellular portion (a.a
- 20-1641), followed by a transmembrane segment (a.a
- 1642-1662), and a short cytoplasmic tail (a.a
- 1663-1709) with no known signal transduction or endocytosis motifs
- The extracellular portion contains an N-terminal Ig-like V-type domain (a.a
- 20-136), followed by sixteen Ig-like C2-type domains
- Sialoadhesin is highly expressed on the subcapsular sinus (SCS) and medullary macrophages in lymph node (LN) and on marginal metallophilic macrophages in the marginal zone (MZ) of spleen
- Although sialic acids are found on the surface of all cells and most secreted proteins, Only heavily sialylated, multimeric structures are captured by Sialoadhesin on macrophages via its N-terminal Ig-like V-type domain due to a low (millimolar) affinity toward sialylic acid
- Sialoadhesin-mediated sialic-acid recognition allows macrophages to engage sialylated pathogens and stimulate inflammatory responses
- Sialoadhesin is also reported to capture of B cell-derived exosomes via their surface-expressed α2, 3-linked sialic acids
- In the lymph node, exosomes are not retained in the subcapsular sinus of Siglec1-knockout mice and penetrate deeper into the paracortex, causing an enhanced response to antigen-pulsed exosomes among Siglec1-/- mice.
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Antigen: Siglec-1 (CD169)
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: Q9BZZ2
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with all three spliced isoforms of human Siglec-1 (CD169)/Sialoadhesin reported by UniProt (Q9BZZ2).
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2a κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 5F1.1
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: SIGLEC1, SN
Immunogen: GST-tagged recombinant human Siglec-1 (CD169) N-terminal fragment containing the Ig-like V-type domain.
Quantity: 100 μg
Research Discipline: Cell Structure
Gene ID (Entrez): NP_075556
Target Species: Human, Mouse
Form: Purified
Antigen:
Siglec-1 (CD169)
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
Q9BZZ2
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with all three spliced isoforms of human Siglec-1 (CD169)/Sialoadhesin reported by UniProt (Q9BZZ2).
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2a κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
5F1.1
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
SIGLEC1, SN
Immunogen:
GST-tagged recombinant human Siglec-1 (CD169) N-terminal fragment containing the Ig-like V-type domain.
Quantity:
100 μg
Research Discipline:
Cell Structure
Gene ID (Entrez):
NP_075556
Target Species:
Human, Mouse
Form:
Purified
Antigen: __
Classification: __
Conjugate: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene Accession No.:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Isotype:
__
Applications:
__
Clone:
__
Formulation:
__
Gene Symbols:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Antigen: WASF2/WAVE-2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: NP_001188333
Host Species: Mouse
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG1 κ
Applications: Immunocytochemistry, Western Blot
Clone: ZZ36-12
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: WASF2, WAVE2
Immunogen: His-tagged recombinant protein corresponding to the C-terminus of Human WASF2/WAVE-2.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: __
Antigen:
WASF2/WAVE-2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
NP_001188333
Host Species:
Mouse
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Western Blot
Clone:
ZZ36-12
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
WASF2, WAVE2
Immunogen:
His-tagged recombinant protein corresponding to the C-terminus of Human WASF2/WAVE-2.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
__
Antigen: TKS5
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 13H6.3 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 60 amino acids crom the C-terminal half.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 13H6.3
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols: SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen: GST/His-tagged recombinant fragment corresponding to 60 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity: 25 μg
Research Discipline: Cell Structure
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Antigen:
TKS5
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 13H6.3 detects SH3 and PX domain-containing protein 2A (adapter protein TKS5) in human cells. It targets and epitope with in 60 amino acids crom the C-terminal half.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
13H6.3
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Symbols:
SH3PXD2A;FISH;KIAA0418;SH3MD1;TKS5
Immunogen:
GST/His-tagged recombinant fragment corresponding to 60 amino acids from the C-terminal half of human SH3 and PX domain-containing protein 2A (Adapter protein TKS5).
Quantity:
25 μg
Research Discipline:
Cell Structure
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified