MABT827AF55

MilliporeSigma™ Dystrophin, Mouse, Alexa Fluor 555, Clone: 2C6 (MANDYS106) ,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABT827AF55-Each-of-1 In Stock ₹ 37,728.54

MABT827AF55 - Each of 1

₹ 37,728.54

In Stock

Quantity

1

Base Price: ₹ 37,728.54

GST (18%): ₹ 6,791.137

Total Price: ₹ 44,519.677

Antigen

Dystrophin

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Purified mouse IgG2a Alexa Fluor™ 555 conjugate in buffer containing PBS, 1.5% BSA with 0.05% Sodium Azide.

Gene Accession No.

P11532

Immunogen

TrpE-tagged recombinant protein corresponding to the Exon 43-coded pectrin-like repeat 16 region of human Dystrophin.

Quantity

100 μL

Research Discipline

Cell Structure

Gene ID (Entrez)

NP_000100

Target Species

Human

Isotype

IgG2a κ

Applications

Immunofluorescence

Clone

2C6 (MANDYS106)

Conjugate

Alexa Fluor 555

Gene

DMD, BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85

Host Species

Mouse

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Detects dystrophin spliced isoforms 1-4, but not isoforms 5-10, or utrophin. Positive muscle membrane staining of tissue samples from healthy donors, reduced staining of Becker muscular dystrophy (BMD) biopsies, and no staining is seen with Duchenne muscular dystrophy (DMD) biopsy samples (Anthony, K., et al. (2011). Brain. 134(Pt 12):3547-3559).

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

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Description

  • Dystrophin (UniProt P11532) is encoded by the DMD (also known as BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85) gene (Gene ID 1756) in human
  • Dystrophin is localized to the inner part of the muscle fiber cell membrane (sarcolemma), where it forms the dystrophin-associated glycoprotein complex (DGC) that links the extracellular matrix to the actin cytoskeleton
  • Dystrophin plays an important role in stabilizing the muscle fibre against the mechanical forces of muscle contraction by providing a shock-absorbing connection between the cytoskeleton and the extracellular matrix
  • Duchenne muscular dystrophy (DMD) is caused by gene mutations that disrupt the open reading frame (ORF) and prevent the full translation of dystrophin
  • ORF restoration by exon skipping using antisense oligonucleotides targeted to splicing elements are designed to transform the DMD phenotype to that of the milder disorder, Becker muscular dystrophy (BMD), typically caused by in-frame dystrophin deletions that allow the production of an internally deleted but partially functional dystrophin.

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Show Difference

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MilliporeSigma™

MABT827AF55

--


Antigen:
Dystrophin

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse IgG2a Alexa Fluor™ 555 conjugate in buffer containing PBS, 1.5% BSA with 0.05% Sodium Azide.

Gene Accession No.:
P11532

Immunogen:
TrpE-tagged recombinant protein corresponding to the Exon 43-coded pectrin-like repeat 16 region of human Dystrophin.

Quantity:
100 μL

Research Discipline:
Cell Structure

Gene ID (Entrez):
NP_000100

Target Species:
Human

Isotype:
IgG2a κ

Applications:
Immunofluorescence

Clone:
2C6 (MANDYS106)

Conjugate:
Alexa Fluor 555

Gene:
DMD, BMD, CMD3B, DXS142, DXS164, DXS206, DXS230, DXS239, DXS268, DXS269, DXS270, DXS272, MRX85

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Detects dystrophin spliced isoforms 1-4, but not isoforms 5-10, or utrophin. Positive muscle membrane staining of tissue samples from healthy donors, reduced staining of Becker muscular dystrophy (BMD) biopsies, and no staining is seen with Duchenne muscular dystrophy (DMD) biopsy samples (Anthony, K., et al. (2011). Brain. 134(Pt 12):3547-3559).

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Img

MilliporeSigma™

MABT827MI

--


Antigen:
Dystrophin

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
P11532-1

Immunogen:
TrpE-tagged recombinant protein corresponding to the Exon 43-coded pectrin-like repeat 16 region of human Dystrophin.

Quantity:
100 μL

Research Discipline:
Cell Structure

Gene ID (Entrez):
NP_000100

Target Species:
Human

Isotype:
IgG2a κ

Applications:
Western Blot

Clone:
2C6 (MANDYS106)

Conjugate:
__

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

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Sigma Aldrich

MABT831

clone BB2SS3F3, from mouse...


Antigen:
__

Classification:
__

Concentration:
__

Formulation:
__

Gene Accession No.:
__

Immunogen:
__

Quantity:
__

Research Discipline:
__

Gene ID (Entrez):
__

Target Species:
__

Isotype:
__

Applications:
__

Clone:
__

Conjugate:
__

Gene:
__

Host Species:
__

Purification Method:
__

Regulatory Status:
__

Primary or Secondary:
__

Test Specificity:
__

Content And Storage:
__

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MilliporeSigma

MABT83125UG

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Antigen:
Lamin B Receptor (LBR)

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.

Gene Accession No.:
__

Immunogen:
GST-tagged recombinant fragment corresponding to the first 211 amino acids from human Lamin B receptor.

Quantity:
25 μg

Research Discipline:
Cell Structure

Gene ID (Entrez):
__

Target Species:
Human, Mouse

Isotype:
IgG1 κ

Applications:
Immunocytochemistry, Immunofluorescence, Western Blot

Clone:
BB2SS3F3

Conjugate:
Unconjugated

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone BB2SS3F3 detects Lamin B receptor in human cells. It targets an epitope within the first 211 amino acids.

Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.