Description

• General description: 7β-hydroxycholesterol (7βOHC) is an oxidized derivative of cholesterol.[1] 7β-hydroxycholesterol-d7 is the deuterated form of 7β-hydroxycholesterol.
• Application: 7β-hydroxycholesterol-d7 has been used:as cholesterol oxidation product for mass spectroscopy analysis[2]as an internal standard for spiking white adipose tissue and plasma samples for mass spectroscopy analysis[3]as an internal standard working solution in gas chromatography- triple-quadrupole mass spectrometry[4]as an isotopically labeled internal standard in tandem mass spectroscopy analysis for plasma sterol quantification[5]
• Biochem/physiol Actions: 7β-hydroxycholesterol-d7 (7β-OHC) along with 7-ketocholesterol (7-KC) plays a key role in atherogenesis. It is distributed extensively in the arterial compartment of apo- E knockout mice.[6] 7βOHC induces apoptosis via activation of glycogen synthase kinase-3 (GSK3). It also triggers reactive oxygen species (ROS) resulting in mitochondrial dysfunction. 7βOHC favors demyelination and is a potential oxidized oxysterol in X-linked adrenoleukodystrophy (X-ALD) disorder.[1]
• Packaging: 5 mL Amber Glass Screw Cap Vial (700044P-1mg)