cholestanol-d5

Description

• General description: Cholestanol-d5 is a deuterated form of cholestanol. Cholestanol is a plant saturated sterol and has Δ5 double bond to the 5α position in the cholesterol structure[1] and is a 5α-dihydro derivative of cholesterol.[2]
• Biochem/physiol Actions: Cholestanol deuterated has been administered in small intestine samples for the quantification of sterols by gas chromatography-mass spectrometry.[1] The levels of cholesterol and cholestanol are elevated in tendons and brain in cerebrotendinous xanthomatosis due to the CYP27A1 (Cytochrome P450 Family 27 Subfamily A Member 1) deficiency.[3] Cholestanol-d5 is useful as an internal standard to spike sediment samples for tandem mass spectrometry (MS/MS) for fecal sterol quantification.[4] Cholestanol is a cholesterol absorption biomarker.[5]
• Packaging: 5 mL Amber Glass Screw Cap Vial (700094P-1mg)