7121030
Tocris Bioscience™ LDN 193189 dihydrochloride
Potent and selective ALK2 and ALK3 inhibitor; inhibits BMP4 signaling; promotes neural induction of hPSCs
Manufacturer: Fischer Scientific
CAS Number: 1435934-00-1
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Chemical Name or Material
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Synonym
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Molecular Formula
C25H22N60.2 HCl
Physical Form
Solid
Product Type
Bioactive Small Molecule
CAS
1435934-00-1
Target
BMP and Other Activin Receptor Inhibitors
Formula Weight
479.4
Color
Orange
Purity
98%
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ LDN 193189 dihydrochloride | Fischer Scientific | ₹ 28,063.68 | |
| | Tocris Bioscience™ LDN 193189 dihydrochloride | Fischer Scientific | ₹ 1,06,094.40 | |
 | 1435934-00-1 | LDN 193189 hydrochloride | A2B Chem | ₹ 1,967.88 - ₹ 16,940.88 |
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Description
- LDN 193189 dihydrochloride is a potent and selective ALK2 and ALK3 inhibitor (IC50 values are 5 and 30 nM, respectively); inhibits BMP4-mediated Smad1/5/8 activation
- Exhibits >200-fold selectivity for BMP signaling over TGF-β signaling
- Also exhibits selectivity over AMPK, PDGFR and MAPK signaling
- Promotes neural induction of hPSCs in combination with SB 431542 (Cat.No
- 1614)
- Also induces differentiation of hPSCs into nociceptive sensory neurons in combination with SB 431542 (Cat.No
- 1614), SU 5402 (Cat.No.3300), CHIR 99021 (Cat.No
- 4423) and DAPT (Cat.No
- 2634)
- LDN 193189 synthesized to Ancillary Material Grade also available
- For more information about how LDN 193189 dihydrochloride may be used, see our protocols: Generation of β cells from hPSCs, Generating Midbrain Dopaminergic Neurons from hPSCs, Accelerated Induction of Cortical Neurons from hiPSCs .
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
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Chemical Name or Material: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Synonym: 4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Molecular Formula: C25H22N60.2 HCl
Physical Form: Solid
Product Type: Bioactive Small Molecule
CAS: 1435934-00-1
Target: BMP and Other Activin Receptor Inhibitors
Formula Weight: 479.4
Color: Orange
Purity: 98%
Chemical Name or Material:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Synonym:
4-[6-[4-(1-Piperazinyl)phenyl]pyrazolo[1,5-a]pyrimidin-3-yl]quinoline dihydrochloride
Molecular Formula:
C25H22N60.2 HCl
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
CAS:
1435934-00-1
Target:
BMP and Other Activin Receptor Inhibitors
Formula Weight:
479.4
Color:
Orange
Purity:
98%
Chemical Name or Material: CZC 25146
Synonym: N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Molecular Formula: C22H25FN6O4S
Physical Form: Solid
Product Type: Bioactive Small Molecule
CAS: 1191911-26-8
Target: __
Formula Weight: 488.54
Color: Pale-purple
Purity: >98%
Chemical Name or Material:
CZC 25146
Synonym:
N-[2-[[5-Fluoro-2-[[2-methoxy-4-(4-morpholinyl)phenyl]amino]-4-pyrimidinyl]amino]phenyl]methanesulfonamide
Molecular Formula:
C22H25FN6O4S
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
CAS:
1191911-26-8
Target:
__
Formula Weight:
488.54
Color:
Pale-purple
Purity:
>98%
Chemical Name or Material: AMG 837 hemicalcium salt
Synonym: (βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
Molecular Formula: C26H20F3O3.?Ca
Physical Form: Solid
Product Type: Bioactive Small Molecule
CAS: 1291087-14-3
Target: __
Formula Weight: 457.47
Color: White
Purity: >98%
Chemical Name or Material:
AMG 837 hemicalcium salt
Synonym:
(βS)-β-1-Propyn-1-yl-4-[[4'-(trifluoromethyl)[1,1'-biphenyl]-3-yl]methoxy]benzenepropanoic acid hemicalcium salt
Molecular Formula:
C26H20F3O3.?Ca
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
CAS:
1291087-14-3
Target:
__
Formula Weight:
457.47
Color:
White
Purity:
>98%
Chemical Name or Material: Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Synonym: Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Molecular Formula: C23H26N4O5S
Physical Form: Solid
Product Type: Bioactive Small Molecule
CAS: 919351-41-0
Target: P2Y Receptor Antagonists
Formula Weight: 470.54
Color: White
Purity: 98%
Chemical Name or Material:
Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Synonym:
Ethyl 5-cyano-2-methyl-6-[4-[[[(phenylmethyl)sulfonyl]amino]carbonyl]-1-piperidinyl]-3-pyridinecarboxylate
Molecular Formula:
C23H26N4O5S
Physical Form:
Solid
Product Type:
Bioactive Small Molecule
CAS:
919351-41-0
Target:
P2Y Receptor Antagonists
Formula Weight:
470.54
Color:
White
Purity:
98%