MilliporeSigma™ Calbiochem™ Histone Acetyltransferase Inhibitor VIII, NU9056

Description

• A cell-permeable disulfane compound that is reported to be more potent against KAT5/Tip60 than PCAF, p300, and GCN5 in cell-free HAT activity assays (IC 50 ≤2, ≤36, ≤60, and >100μM, respectively) and effectively reduce H3K14, H4K8, H4K16, but not α-tubulin, acetylation level in LNCaP prostate cancer cells (max inhibition at 5-10μM)
• Shown to induce cell cycle arrest and apoptosis (17 to 24μM) in LNCaP cultures and exhibit antiproliferation activity in both androgen-responsive and androgen-independent CaP cultures (GI 50 from 7.5 to 27μM)
• Please note that the molecular weight for this compound is batch-specific due to variable water content
• Please refer to the vial label or the certificate of analysis for the batch-specific molecular weight
• The molecular weight provided represents the baseline molecular weight without water.