SML1923
A-395 hydrochloride
≥98% (HPLC)
Manufacturer: Sigma Aldrich
CAS Number: 2089148-72-9
Synonym(S): (3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-4-{4-[4-(methanesulfonyl)piperazin-1-yl]phenyl}-N,N-dimethylpyrrolidin-3-amine hydrochloride
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| 5 MG | SML1923-5-MG | In Stock | ₹ 17,742.18 |
| 25 MG | SML1923-25-MG | In Stock | ₹ 49,405.30 |
SML1923 - 5 MG
In Stock
Quantity
1
Base Price: ₹ 17,742.18
GST (18%): ₹ 3,193.592
Total Price: ₹ 20,935.772
Quality Level
100
Assay
≥98% (HPLC)
form
powder
storage condition
desiccated
color
white to light brown
solubility
H2O: 10 mg/mL, clear
storage temp.
2-8°C
SMILES string
FC1=CC=CC2=C1C(N3C[C@H](C(C=C4)=CC=C4N5CCN(S(C)(=O)=O)CC5)[C@@H](N(C)C)C3)CC2
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Medchemexpress LLC HY-101512 10mg Medchemexpress, A-395 CAS:2089148-72-9 Purity:>98% | Medchemexpress LLC | ₹ 17,069.22 | |
 | eMolecules Medchem Express / A-395 / 5mg / 415685817 / HY-101512 / / 2089148-72-9 / [null] / 486.650 / C26H35FN4O2S | eMolecules | ₹ 13,853.88 | |
 | 2089148-72-9 | (3R,4S)-1-(7-Fluoro-2,3-dihydro-1H-inden-1-yl)-N,N-dimethyl-4-(4-(4-(methylsulfonyl)piperazin-1-yl)phenyl)pyrrolidin-3-amine | A2B Chem | ₹ 2,652.36 - ₹ 14,374.08 |
Related Products
Description
- Biochem/physiol Actions: A-395 is a potent and selective chemical probe for the polycomb protein EED (embryonic ectoderm development), an essential component of Polycomb repressive complex 2 (PRC2), involved in transcriptional repression through methylation of histone H3K27. A-395 has been found to bind to EED in vitro with a Ki value of 0.4 nM, inhibit the PRC2 complex with an IC50 value 34 nM for methylation of H3K27, and have >100-fold selectivity over other histone methyltransferases and non-epigenetic targets. In RD rhabdoid tumor cell line A-395 inhibited the PRC2 complex with an IC50 value of 90 nM, inhibiting the formation of H3K27me3. For characterization details of A-395, please visit the A-395 probe summary on the Structural Genomics Consortium (SGC) website.A-395N is the negative control for the active enantiomer, A-395. A-395N is available from Sigma. To learn more about and purchase A-395N, click here.To learn about other SGC chemical probes for epigenetic targets, visit sigma.com/sgc
- Features and Benefits: A-395 is an epigenetic chemical probe available through a partnership with the Structural Genomics Consortium (SGC). To learn more and view other SGC epigenetic probes, visit sigma.com/SGC.
SAFETY INFORMATION
Pictograms
Signal Word
Danger
Hazard Statements
Precautionary Statements
P264 - P270 - P280 - P301 + P310 - P302 + P352 - P305 + P351 + P338
Hazard Classifications
Acute Tox. 3 Oral - Eye Irrit. 2 - Skin Irrit. 2
WGK
WGK 3
Flash Point(F)
Not applicable
Flash Point(C)
Not applicable
Compare Similar Items
Show Difference
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
storage condition: desiccated
color: white to light brown
solubility: H2O: 10 mg/mL, clear
storage temp.: 2-8°C
SMILES string: FC1=CC=CC2=C1C(N3C[C@H](C(C=C4)=CC=C4N5CCN(S(C)(=O)=O)CC5)[C@@H](N(C)C)C3)CC2
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
storage condition:
desiccated
color:
white to light brown
solubility:
H2O: 10 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
FC1=CC=CC2=C1C(N3C[C@H](C(C=C4)=CC=C4N5CCN(S(C)(=O)=O)CC5)[C@@H](N(C)C)C3)CC2
Quality Level: 100
Assay: ≥98% (HPLC)
form: powder
storage condition: __
color: white to beige
solubility: DMSO: 15 mg/mL, clear
storage temp.: 2-8°C
SMILES string: O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41
Quality Level:
100
Assay:
≥98% (HPLC)
form:
powder
storage condition:
__
color:
white to beige
solubility:
DMSO: 15 mg/mL, clear
storage temp.:
2-8°C
SMILES string:
O=C(C)C1=CC(C2=CC=CC=C2OCC3CC3)=C4N=CC=CN41
Quality Level: __
Assay: ≥98% (HPLC)
form: powder
storage condition: __
color: white to beige
solubility: __
storage temp.: 2-8°C
SMILES string: O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O
Quality Level:
__
Assay:
≥98% (HPLC)
form:
powder
storage condition:
__
color:
white to beige
solubility:
__
storage temp.:
2-8°C
SMILES string:
O[C@@H]1[C@@H]([C@@H](O)C2=CC=CC=C2)O[C@@H](N3C(N=CN=C4N)=C4C=C3)[C@@H]1O
Quality Level: __
Assay: ≥98% (HPLC)
form: powder
storage condition: __
color: white to beige
solubility: DMSO: 2 mg/mL, clear (warmed)
storage temp.: 2-8°C
SMILES string: CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)=O)C
Quality Level:
__
Assay:
≥98% (HPLC)
form:
powder
storage condition:
__
color:
white to beige
solubility:
DMSO: 2 mg/mL, clear (warmed)
storage temp.:
2-8°C
SMILES string:
CN(C(/C(C#N)=C/C(O1)=CC=C1C2=NC3=CN=C(NC=C4)C4=C3N2C5CCCCC5)=O)C