ABE1451MI

MilliporeSigma™ phospho BRD4 (Ser492), Rabbit, Unlabeled, Polyclonal,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 ABE1451MI-Each-of-1 In Stock ₹ 39,063.27

ABE1451MI - Each of 1

₹ 39,063.27

In Stock

Quantity

1

Base Price: ₹ 39,063.27

GST (18%): ₹ 7,031.389

Total Price: ₹ 46,094.659

Antigen

phospho BRD4 (Ser492)

Classification

Polyclonal

Conjugate

Unconjugated

Gene

BRD4, HUNK1, MCAP

Host Species

Rabbit

Purification Method

Affinity Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

The target phospho-serine residue is present in all human (pSer492) and murine (pSer493) BRD4 spliced isoforms reported by UniProt (O60885 and Q9ESU6). This polyclonal antibody is shown to exhibit stronger immunoreactivity toward BRD4 phosphopeptide with dual pSer492/494 (equivalent to mouse pSer493/495) phosphorylation than the corresponding peptide with only pSer492 (equivalent to mouse Ser493) phosphorylation (Korb, E., et al. (2015). Nat. Neurosci. 18(10):1464-1473).

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Applications

Immunocytochemistry, Western Blot

Concentration

Please refer to lot specific datasheet.

Formulation

Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.

O60885

Immunogen

KLH-conjugated linear peptide corresponding to a human BRD4 sequence containing phosphorylated Ser492 (equivalent to mouse Ser493).

Quantity

100 μL

Research Discipline

Epigenetics & Nuclear Function

Gene ID (Entrez)

NP_490597

Target Species

Human

Form

Purified

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Description

  • Bromodomain-containing protein 4 (UniProt O60885; also known as MCAP, Mitotic chromosome-associated protein, Protein HUNK1) is encoded by the BRD4 (also known as HUNK1, MCAP) gene (Gene ID 23476) in human
  • BRD4 is a BET (bromodomain and extra-terminal) protein family member that functions as a chromatin reader by binding acetylated lysines in histones
  • BRD4 is an important transcription regulator in many cell types, including transcription in response to external cues
  • BRD4 plays an essential role in neuronal function and mediates the transcriptional regulation underlying learning and memory
  • BRD4 regulates IEG transcription in neurons upon phosphorylation by casein kinase 2 (CK2), which is activated in response to neuronal stimulation
  • Brd4 knockout in mice is lethal, while Brd4 function blockage by inhibitor JQ1 (Cat
  • No
  • 500586) treatment is reported to affect the transcription of critical synaptic proteins, resulting in memory deficits and decreased seizure susceptibility in mice.

Compare Similar Items

Show Difference

Img

MilliporeSigma™

ABE1451MI

--


Antigen:
phospho BRD4 (Ser492)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
BRD4, HUNK1, MCAP

Host Species:
Rabbit

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
The target phospho-serine residue is present in all human (pSer492) and murine (pSer493) BRD4 spliced isoforms reported by UniProt (O60885 and Q9ESU6). This polyclonal antibody is shown to exhibit stronger immunoreactivity toward BRD4 phosphopeptide with dual pSer492/494 (equivalent to mouse pSer493/495) phosphorylation than the corresponding peptide with only pSer492 (equivalent to mouse Ser493) phosphorylation (Korb, E., et al. (2015). Nat. Neurosci. 18(10):1464-1473).

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Applications:
Immunocytochemistry, Western Blot

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
O60885

Immunogen:
KLH-conjugated linear peptide corresponding to a human BRD4 sequence containing phosphorylated Ser492 (equivalent to mouse Ser493).

Quantity:
100 μL

Research Discipline:
Epigenetics & Nuclear Function

Gene ID (Entrez):
NP_490597

Target Species:
Human

Form:
Purified

Img

Sigma Aldrich

ABE1453

from rabbit, purified by affinity c...


Antigen:
__

Classification:
__

Conjugate:
__

Gene:
__

Host Species:
__

Purification Method:
__

Regulatory Status:
__

Primary or Secondary:
__

Test Specificity:
__

Content And Storage:
__

Applications:
__

Concentration:
__

Formulation:
__

Gene Accession No.:
__

Immunogen:
__

Quantity:
__

Research Discipline:
__

Gene ID (Entrez):
__

Target Species:
__

Form:
__

Img

MilliporeSigma

ABE1453MI

--


Antigen:
phospho Brd4 (Ser492/Ser494)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
__

Host Species:
Rabbit

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
This rabbit polyclonal antibody detects Bromodomain-conntaining protein 4 phosphorylated at Ser492/Ser494. It targets an epitope of 14 amino acids in the N-terminal half.

Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.

Applications:
Immunocytochemistry, Dot Blot, Western Blot, Immunohistochemistry

Concentration:
Please refer to lot specific datasheet.

Formulation:
__

Gene Accession No.:
__

Immunogen:
KLH-conjugated linear peptide corresponding to 14 amino acids surrounding Ser492/Ser494 from the internal N-terminal half of human phospho Brd4 protein.

Quantity:
100 μL

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_490597

Target Species:
Human, Mouse, Rat, Porcine

Form:
__

Img

MilliporeSigma

ABE1454

--


Antigen:
NR4A1 (Nur77)

Classification:
Polyclonal

Conjugate:
Unconjugated

Gene:
__

Host Species:
Rabbit

Purification Method:
Affinity Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
This rabbit polyclonal antibody detects Nuclear receptor subfamily 4 group A member 1 (NR4A1) in human, Monkey, and Murine cells It targets an epitope within 17 amino acids from the N-terminal region.

Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.

Applications:
Western Blot, Immunocytochemistry

Concentration:
Please refer to lot specific datasheet.

Formulation:
__

Gene Accession No.:
__

Immunogen:
KLH-conjugated linear peptide corresponding to 17 amino acids from the N-terminal region of human Nuclear receptor subfamily 4 group A member 1 (NR4A1). The immunogen sequence is conserved in all 3 isoforms.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_001189162.1

Target Species:
Monkey, Mouse, Human

Form:
__