ABS1509MI
MilliporeSigma™ Rabbit anti-phospho-Neph1 (Tyr637/638), Polyclonal,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1509MI-Each-of-1 | In Stock | ₹ 37,453.03 |
ABS1509MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,453.03
GST (18%): ₹ 6,741.545
Total Price: ₹ 44,194.575
Antigen
phospho-Neph1 (Tyr637/638)
Classification
Polyclonal
Gene Accession No.
Q80W68
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Applications
Western Blot
Formulation
Purified rabbit polyclonal antibody in buffer containing PBS/glycine/5% BSA, 0.02% Sodium Azide and 30% glycerol.
Gene Symbols
Kirrel; Kirrel1; Neph1
Immunogen
Linear peptide corresponding to the cytoplasmic domain of mouse phospho-Neph1 (Tyr637/638).
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_001164456
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
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Description
- Specifically detects phospho-Neph1 (Tyr637/638) in Human samples, and it is validated for Western Blotting Kin of IRRE-like protein 1 (UniProt Q80W68; also known as Nephrin-like protein 1, Kin of IRRE like 1, Kin of irregular chiasm-like protein 1) is encoded by the Kirrel (also known as 6720469N11Rik, Kirrel1, Neph1) gene (Gene ID 170643) in murine species
- Podocytes are specialized epithelial cells that are critical components of the glomerular filtration barrier
- Glomerular injury, such as that caused by renal ischemia, is often characterized by the effacement of podocytes, loss of slit diaphragms, and proteinuria
- The podocyte proteins Neph1 and nephrin are critical for maintaining the structural integrity of slit diaphragm and therefore the filtration function of the glomerulus by organizing a signaling complex at the podocyte cell membrane
- The cytoplasmic domain of Neph1 plays a key role in actin cytoskeleton remodeling events that are directly associated with Fyn-mediated Neph1 pTyr637/638 phosphorylation that leads to the recruitment of adapter proteins and signaling molecules, such as Grb2, Csk tyrosine kinase, and ZO-1
- Phosphorylation-induced association between Neph1 and ZO-1 plays a key role in defining the tight junction formation in podocytes.
Compare Similar Items
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Antigen: phospho-Neph1 (Tyr637/638)
Classification: Polyclonal
Gene Accession No.: Q80W68
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Western Blot
Formulation: Purified rabbit polyclonal antibody in buffer containing PBS/glycine/5% BSA, 0.02% Sodium Azide and 30% glycerol.
Gene Symbols: Kirrel; Kirrel1; Neph1
Immunogen: Linear peptide corresponding to the cytoplasmic domain of mouse phospho-Neph1 (Tyr637/638).
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_001164456
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Antigen:
phospho-Neph1 (Tyr637/638)
Classification:
Polyclonal
Gene Accession No.:
Q80W68
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Western Blot
Formulation:
Purified rabbit polyclonal antibody in buffer containing PBS/glycine/5% BSA, 0.02% Sodium Azide and 30% glycerol.
Gene Symbols:
Kirrel; Kirrel1; Neph1
Immunogen:
Linear peptide corresponding to the cytoplasmic domain of mouse phospho-Neph1 (Tyr637/638).
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001164456
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Antigen: Neph1
Classification: Polyclonal
Gene Accession No.: Q80W68
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Applications: Immunoassay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Formulation: Purified rabbit polyclonal antibody in buffer containing PBS/glycine/5% BSA, 0.02% Sodium Azide and 30% glycerol.
Gene Symbols: Kirrel; Kirrel1; Neph1
Immunogen: His-tagged recombinant protein corresponding to the cytoplasmic domain of mouse Neph1.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_001164456
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Antigen:
Neph1
Classification:
Polyclonal
Gene Accession No.:
Q80W68
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Applications:
Immunoassay, Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Formulation:
Purified rabbit polyclonal antibody in buffer containing PBS/glycine/5% BSA, 0.02% Sodium Azide and 30% glycerol.
Gene Symbols:
Kirrel; Kirrel1; Neph1
Immunogen:
His-tagged recombinant protein corresponding to the cytoplasmic domain of mouse Neph1.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001164456
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Antigen: phospho-Ubiquitin (Ser65)
Classification: Polyclonal
Gene Accession No.: P0CG47;P0CG478
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Immunocytochemistry
Formulation: Purified rabbit polyclonal antibody in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: KLH-conjugated linear peptide corresponding to the ubiquitin target region sequence containing phosphorylated Ser65.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_061828;NP_066289
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Antigen:
phospho-Ubiquitin (Ser65)
Classification:
Polyclonal
Gene Accession No.:
P0CG47;P0CG478
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Immunocytochemistry
Formulation:
Purified rabbit polyclonal antibody in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
KLH-conjugated linear peptide corresponding to the ubiquitin target region sequence containing phosphorylated Ser65.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_061828;NP_066289
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Antigen: phospho- NFkB p52, (Ser222)
Classification: Polyclonal
Gene Accession No.: Q00653
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Applications: Western Blot
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: NFKB2; LYT10
Immunogen: KLH-conjugated linear peptide corresponding to the RHD domain of human phospho NFkB p52, (Ser222).
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_002493
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Antigen:
phospho- NFkB p52, (Ser222)
Classification:
Polyclonal
Gene Accession No.:
Q00653
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Applications:
Western Blot
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
NFKB2; LYT10
Immunogen:
KLH-conjugated linear peptide corresponding to the RHD domain of human phospho NFkB p52, (Ser222).
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_002493
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.