ABS1655
MilliporeSigma™ PDI, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1655-Each-of-1 | In Stock | ₹ 39,186.48 |
ABS1655 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 39,186.48
GST (18%): ₹ 7,053.566
Total Price: ₹ 46,240.046
Antigen
PDI
Classification
Polyclonal
Conjugate
Unconjugated
Gene
P4HB, CLCRP1, ERBA2L, PDI, PDIA1, PO4DB
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody specifically detected the immunogen peptide, but not the control peptide without arginylation at the N-terminal Asp18 (Cha-Molstad, H., et al. (2015). Nat. Cell Biol. 17(7):917-929).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Immunocytochemistry, Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in PBS with 0.05% Sodium Azide.
Gene Accession No.
P07237
Immunogen
Linear peptide corresponding to the N-terminal sequence of arginylated mature human PDI.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_000909
Target Species
Human
Related Products
Description
- Protein disulfide-isomerase (EC 5.3.4.1; UniProt P07237; also known as Cellular thyroid hormone-binding protein, p55, P4Hbeta, PDI, Prolyl 4-hydroxylase subunit beta) is encoded by the P4HB (also known as CLCRP1, ERBA2L, PDI, PDIA1, PO4DB) gene (Gene ID 5034) in human
- Protein disulphide isomerase (PDI), BiP (GRP78 or heat shock 70kDa protein 5), and calreticulin (CRT) are ER lumen folding factors that, together with other PTM enzymes, assist the process of newly synthesized proteins before their release from ER
- PDI, BiP, and CRT themselves are subject to posttranslational signal peptide removal after their synthesis, exposing D18, E19, and E18 at the newly formed N-terminus, respectively
- The N-terminus D and E residues of the mature proteins are permissive to arginine-tRNA-protein transferase 1/ATE1-catalyzed arginylation, forming arginylated mature proteins (R-DPI, R-BiP, and R-CRT) with altered cellular localization to allow their participation in non-ER functions
- Although only the basal levels of R-PDI and R-CRT, but not R-BiP, are generally detectible in non-stimulated cells, upregulated N-terminal arginylation of all three proteins is observed upon cytosolic dsDNA exposure and proteasomal inhibition, indicating a shared role in innate immune responses to invading microbes
- In addition, ER stress induction by thapsigargin treatment synergistically boosts proteasomal inhibition-induced upregulation of cellular levels of R-DPI, R-BiP, and R-CRT, suggesting that ER stress accelerates the supply of ER lumenal DPI, BiP, and CRT for N-terminal arginylation.
Compare Similar Items
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Antigen: PDI
Classification: Polyclonal
Conjugate: Unconjugated
Gene: P4HB, CLCRP1, ERBA2L, PDI, PDIA1, PO4DB
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detected the immunogen peptide, but not the control peptide without arginylation at the N-terminal Asp18 (Cha-Molstad, H., et al. (2015). Nat. Cell Biol. 17(7):917-929).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Immunocytochemistry, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in PBS with 0.05% Sodium Azide.
Gene Accession No.: P07237
Immunogen: Linear peptide corresponding to the N-terminal sequence of arginylated mature human PDI.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000909
Target Species: Human
Antigen:
PDI
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
P4HB, CLCRP1, ERBA2L, PDI, PDIA1, PO4DB
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detected the immunogen peptide, but not the control peptide without arginylation at the N-terminal Asp18 (Cha-Molstad, H., et al. (2015). Nat. Cell Biol. 17(7):917-929).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Immunocytochemistry, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in PBS with 0.05% Sodium Azide.
Gene Accession No.:
P07237
Immunogen:
Linear peptide corresponding to the N-terminal sequence of arginylated mature human PDI.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000909
Target Species:
Human
Antigen: CHMP3
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects Charged multivesicular body protein 3 in human cells.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Applications: Immunocytochemistry, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: A full-length human recombinant charged multivesicular body protein 3 (CHMP3).
Quantity: 25 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human
Antigen:
CHMP3
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects Charged multivesicular body protein 3 in human cells.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Applications:
Immunocytochemistry, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
A full-length human recombinant charged multivesicular body protein 3 (CHMP3).
Quantity:
25 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human
Antigen: Phosphohistidine (pHis)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody reacted with pHis- and pPza-, but not His-, pTyr-, pSer-, or pThr-, conjugated BSA. Specificity testing using N1-pHis analog showed minimal cross-reactivity.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: ELISA, Immunoprecipitation, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 100mM glycine pH 2.2, 100mM Tris pH 10 with 0.05% Sodium Azide.
Gene Accession No.: __
Immunogen: KLH-conjugated non-hydrolyzable phosphohistidine analogue 4-phosphopyrazol-2-yl alanine (pPza).
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human
Antigen:
Phosphohistidine (pHis)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody reacted with pHis- and pPza-, but not His-, pTyr-, pSer-, or pThr-, conjugated BSA. Specificity testing using N1-pHis analog showed minimal cross-reactivity.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
ELISA, Immunoprecipitation, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 100mM glycine pH 2.2, 100mM Tris pH 10 with 0.05% Sodium Azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated non-hydrolyzable phosphohistidine analogue 4-phosphopyrazol-2-yl alanine (pPza).
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human
Antigen: Uteroglobin
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Goat
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antibody detects uteroglobin in mouse and rat tissues.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: His-tagged full length recombinant rat uteroglobin.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_037183
Target Species: Mouse
Antigen:
Uteroglobin
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Goat
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antibody detects uteroglobin in mouse and rat tissues.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Immunofluorescence, Immunohistochemistry, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
His-tagged full length recombinant rat uteroglobin.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_037183
Target Species:
Mouse