ABS2103
MilliporeSigma™ BiP (GRP78), arginylated (Nt-Glu19), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS2103-Each-of-1 | In Stock | ₹ 40,197.80 |
ABS2103 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,197.80
GST (18%): ₹ 7,235.604
Total Price: ₹ 47,433.404
Antigen
BiP (GRP78), arginylated (Nt-Glu19)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
HSPA5, GRP78
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antibody specifically detected the immunogen peptide, but not the control peptide without arginylation at the N-terminal Glu19 (Cha-Molstad, H., et al. (2015). Nat. Cell Biol. 17(7):917-929).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
ELISA, Immunocytochemistry, Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing PBS with 0.05% Sodium Azide.
Gene Accession No.
P11021
Immunogen
Linear peptide corresponding to the N-terminal sequence of arginylated mature human BiP (GRP78).
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_005338
Target Species
Human
Related Products
Description
- 78kDa glucose-regulated protein (UniProt P11021; also known as BiP, Endoplasmic reticulum lumenal Ca(2+)-binding protein grp78, GRP-78, Heat shock 70kDa protein 5, Immunoglobulin heavy chain-binding protein) is encoded by the HSPA5 (also known as GRP78) gene (Gene ID 3309) in human
- BiP (GRP78 or heat shock 70kDa protein 5), calreticulin (CRT), and protein disulphide isomerase (PDI) are ER lumen folding factors that, together with other PTM enzymes, assist the process of newly synthesized proteins before their release from ER
- BiP, CRT, and PDI themselves are subject to posttranslational signal peptide removal after their synthesis, exposing E19, E18, and D18 at the newly formed N-terminus, respectively
- The N-terminus D and E residues of the mature proteins are permissive to arginine-tRNA-protein transferase 1/ATE1-catalyzed arginylation, forming arginylated mature proteins (R-BiP, R-CRT, R-PDI) with altered cellular localization to allow their participation in non-ER functions
- Although only the basal levels of R-CRT and R-PDI, but not R-BiP, are generally detectible in non-stimulated cells, upregulated N-terminal arginylation of all three proteins is observed upon cytosolic dsDNA exposure and proteasomal inhibition, indicating a shared role in innate immune responses to invading microbes
- In addition, ER stress induction by thapsigargin treatment synergistically boosts proteasomal inhibition-induced upregulation of cellular levels of R-BiP, R-CRT, and R-PDI, suggesting that ER stress accelerates the supply of ER lumenal BiP, CRT, and DPI for N-terminal arginylation.
Compare Similar Items
Show Difference
Antigen: BiP (GRP78), arginylated (Nt-Glu19)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: HSPA5, GRP78
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody specifically detected the immunogen peptide, but not the control peptide without arginylation at the N-terminal Glu19 (Cha-Molstad, H., et al. (2015). Nat. Cell Biol. 17(7):917-929).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: ELISA, Immunocytochemistry, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing PBS with 0.05% Sodium Azide.
Gene Accession No.: P11021
Immunogen: Linear peptide corresponding to the N-terminal sequence of arginylated mature human BiP (GRP78).
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_005338
Target Species: Human
Antigen:
BiP (GRP78), arginylated (Nt-Glu19)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
HSPA5, GRP78
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody specifically detected the immunogen peptide, but not the control peptide without arginylation at the N-terminal Glu19 (Cha-Molstad, H., et al. (2015). Nat. Cell Biol. 17(7):917-929).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
ELISA, Immunocytochemistry, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing PBS with 0.05% Sodium Azide.
Gene Accession No.:
P11021
Immunogen:
Linear peptide corresponding to the N-terminal sequence of arginylated mature human BiP (GRP78).
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_005338
Target Species:
Human
Antigen: phospho-CaMKII beta (Ser331)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects beta subunit of CaM Kinase II when phosphorylated on Ser331.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Applications: Immunocytochemistry, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: A linear peptide corresponding to 10 amino acids surrounding phopho serine 331 of rat CaM Kinase II beta.
Quantity: 25 μL
Research Discipline: Neuroscience
Gene ID (Entrez): __
Target Species: Rat
Antigen:
phospho-CaMKII beta (Ser331)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects beta subunit of CaM Kinase II when phosphorylated on Ser331.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Applications:
Immunocytochemistry, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
A linear peptide corresponding to 10 amino acids surrounding phopho serine 331 of rat CaM Kinase II beta.
Quantity:
25 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
__
Target Species:
Rat
Antigen: __
Classification: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Antigen: Vaccinia related kinase-1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects Serine/threonine-protein kinase VRK1 in human cells. It targets an epitope within 30 amino acids from the N-terminal region.
Content And Storage: Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: ELISA, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: __
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to 30 amino acids from the N-terminal region of human Vaccinia-related kinase 1 (VRK1).
Quantity: 25 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_003375
Target Species: Human
Antigen:
Vaccinia related kinase-1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects Serine/threonine-protein kinase VRK1 in human cells. It targets an epitope within 30 amino acids from the N-terminal region.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
ELISA, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
__
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to 30 amino acids from the N-terminal region of human Vaccinia-related kinase 1 (VRK1).
Quantity:
25 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_003375
Target Species:
Human