ABS233AFAMI
MilliporeSigma™ PI3 Kinase p85, N-SH2 domain, Rabbit, Alexa Fluor 488, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS233AFAMI-Each-of-1 | In Stock | ₹ 41,308.37 |
ABS233AFAMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,308.37
GST (18%): ₹ 7,435.507
Total Price: ₹ 48,743.877
Antigen
PI3 Kinase p85, N-SH2 domain
Classification
Polyclonal
Conjugate
Alexa Fluor 488
Gene
Pik3r1
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antibody targets the first SH2 domain region common to human (isoform 1, AS53, p46, p85I), mouse, and rat (isoform p85-alpha, p55-alpha, and p50-alpha) spliced isoforms of PI3 kinase regulatory subunit alpha reported by UniProt (P27986, P26450, Q63787).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Immunocytochemistry
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody Alexa Fluor™ 488 conjugate in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene Accession No.
Q63787
Immunogen
GST-tagged recombinant fragment corresponding to the first SH2 domain of rat PI3 kinase regulatory subunit alpha.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_037137
Target Species
Human
Related Products
Description
- Phosphatidylinositol 3-kinase regulatory subunit alpha (UniProt: Q63787; also known as PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha) is encoded by the Pik3r1 (Gene ID 25513) gene in rat
- PI3 Kinase is a heterodimeric complex composed of an 85kDa regulatory subunit and a 110kDa catalytic subunit
- It binds to activated (phosphorylated) protein tyrosine kinases, through its SH2 domain, and acts as an adapter, mediating the association of the p110 catalytic unit to the plasma membrane
- PI3 Kinase catalyzes the phosphorylation of PI(4,5)P2 (PIP2) inositol ring at the 3 position to generate PI(3,4,5)P3 (PIP3), a potent second messenger that mediates the action of several growth factors
- PI3 kinase is essential for the insulin signaling and also plays an important role in signaling in response to FGFR1, FGFR2, FGFR3, FGFR4, KITLG/SCF, KIT, PDGFRA and PDGFRB
- Tyrosine phosphorylation of growth factor receptors creates docking sites for p85 binding (through its SH2 domains), bringing p85-associated p110 proximal to its lipid substrate on the membrane
- PI3 Kinase is also activated by Ras and by the beta and gamma subunits of heterotrimeric G-proteins.
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Antigen: PI3 Kinase p85, N-SH2 domain
Classification: Polyclonal
Conjugate: Alexa Fluor 488
Gene: Pik3r1
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antibody targets the first SH2 domain region common to human (isoform 1, AS53, p46, p85I), mouse, and rat (isoform p85-alpha, p55-alpha, and p50-alpha) spliced isoforms of PI3 kinase regulatory subunit alpha reported by UniProt (P27986, P26450, Q63787).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Immunocytochemistry
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody Alexa Fluor™ 488 conjugate in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene Accession No.: Q63787
Immunogen: GST-tagged recombinant fragment corresponding to the first SH2 domain of rat PI3 kinase regulatory subunit alpha.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_037137
Target Species: Human
Antigen:
PI3 Kinase p85, N-SH2 domain
Classification:
Polyclonal
Conjugate:
Alexa Fluor 488
Gene:
Pik3r1
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antibody targets the first SH2 domain region common to human (isoform 1, AS53, p46, p85I), mouse, and rat (isoform p85-alpha, p55-alpha, and p50-alpha) spliced isoforms of PI3 kinase regulatory subunit alpha reported by UniProt (P27986, P26450, Q63787).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Immunocytochemistry
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody Alexa Fluor™ 488 conjugate in PBS with 1.5% BSA and 0.05% Sodium Azide.
Gene Accession No.:
Q63787
Immunogen:
GST-tagged recombinant fragment corresponding to the first SH2 domain of rat PI3 kinase regulatory subunit alpha.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_037137
Target Species:
Human
Antigen: PI3 Kinase p85
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Immunoprecipitation, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged recombinant protein corresponding to the N-SH2 domain of rat PI3 Kinase p85.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_037137
Target Species: Human, Rat
Antigen:
PI3 Kinase p85
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Immunoprecipitation, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant protein corresponding to the N-SH2 domain of rat PI3 Kinase p85.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_037137
Target Species:
Human, Rat
Antigen: PI3 Kinase, p85
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Immunoprecipitation, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged recombinant protein corresponding to rat PI3 Kinase, p85.
Quantity: 200 μL
Research Discipline: __
Gene ID (Entrez): NP_037137
Target Species: Human, Rat
Antigen:
PI3 Kinase, p85
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Immunoprecipitation, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant protein corresponding to rat PI3 Kinase, p85.
Quantity:
200 μL
Research Discipline:
__
Gene ID (Entrez):
NP_037137
Target Species:
Human, Rat
Antigen: Cytochrome P450 (scc)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to the C-terminus of rat Cytochrome P450 (scc), a.a. 509-526.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_058982
Target Species: Rat
Antigen:
Cytochrome P450 (scc)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to the C-terminus of rat Cytochrome P450 (scc), a.a. 509-526.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_058982
Target Species:
Rat