ABT1346MI
MilliporeSigma™ Bikunin (CP6), Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABT1346MI-Each-of-1 | In Stock | ₹ 41,307.51 |
ABT1346MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
Bikunin (CP6)
Classification
Polyclonal
Conjugate
Unconjugated
Gene
AMBP, HCP, HI30, IATIL, ITIL, ITILC
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This rabbit polyclonal antiserum targets Inter-alpha-trypsin inhibitor light chain (a.a. 206-352; ITI-LC, Bikunin, EDC1, HI-30, Uronic-acid-rich protein) N-terminal sequence, it will also recognize the precursor protein AMBP (a.a. 1-352; alpha-1-microglobulin/bikunin precursor), but not the other two AMBP-derived products, Alpha-1-microglobulin (a.a. 20-203; A1M, Alpha-1 microglycoprotein, Complex-forming glycoprotein heterogeneous in charge, Protein HC) and Trypstatin (a.a. 284-344).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.
P02760
Immunogen
Diphtheria toxoid-conjugated linear peptide corresponding to human bikunin N-terminal sequence.
Quantity
100 μL
Research Discipline
Cell Structure
Gene ID (Entrez)
NP_001624
Target Species
Human
Form
Serum
Related Products
Description
- Protein AMBP (UniProt P02760; also known as alpha-1-microglobulin/bikunin precursor) is transcribed from the AMBP (also known as HCP, HI30, IATIL, ITIL, ITILC) gene (Gene ID 259) in human as a precursor protein with a signal peptide (a.a
- 1-19), posttranslational cleavages produce Alpha-1-microglobulin (a.a
- 20-203; A1M, Alpha-1 microglycoprotein, Complex-forming glycoprotein heterogeneous in charge, Protein HC), bikunin (a.a
- 206-352; Inter-alpha-trypsin inhibitor light chain, ITI-LC, EDC1, HI-30, Uronic-acid-rich protein), and Trypstatin (a.a
- 284-344)
- Bikunin is a proteoglycan (PG) that contains a single chondroitin sulfate (CS) glycosaminoglycan (GAG) chain with 27-39 monosaccharides attached to Ser10 of the mature core protein
- Bikunin GAG has a non-sulfated domain consisting of 6-22 monosaccharides on the non-reducing end and a sulfated domain of 12-18 monosaccharides on the reducing end, with the sulfation occurring exclusively at the fourth carbon of the GalNAc residues
- During the synthesis of bikunin by hepatocytes, C-terminal aspartate residues of ∽80kDa heavy chains (HC1 and HC2) are covalently linked to the sixth carbon of a GlcUA residue on the non-sulfated region of the CS chain, forming pre-inter-α-inhibitor (pre-IαI or PαI) with one HC
- A second HC can be attached to the non-sulfated region of the CS to form IαI
- IαI is known for its roles in inhibiting serine proteinases, such as plasmin, and as an HC donor for the covalent modification of hyaluronan (HA) to form HC·HA (or SHAP·HA) complexes at sites of inflammation and around the oocyte prior to ovulation
- Tumor necrosis factor-stimulated gene-6 (TSG-6) forms a covalent HC·TSG-6 intermediate and subsequently transfers the HC to the sixth carbon of GlcNAc residues of HA in a transesterification reaction that contributes to the cross-linking and stabilization of HA matrices; in some contexts modification of HA with HC has been implicated in the promotion of leukocyte adhesion
- In addition, the bikunin·CS chain can accept a single HC from IαI via transfer catalyzed by TSG-6 and that HCs could be swapped from bikunin·CS chain to HA
- (Briggs, D.C., et al
- (2015)
- J
- Biol
- Chem
- 290(48):28708-28723).
Compare Similar Items
Show Difference
Antigen: Bikunin (CP6)
Classification: Polyclonal
Conjugate: Unconjugated
Gene: AMBP, HCP, HI30, IATIL, ITIL, ITILC
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antiserum targets Inter-alpha-trypsin inhibitor light chain (a.a. 206-352; ITI-LC, Bikunin, EDC1, HI-30, Uronic-acid-rich protein) N-terminal sequence, it will also recognize the precursor protein AMBP (a.a. 1-352; alpha-1-microglobulin/bikunin precursor), but not the other two AMBP-derived products, Alpha-1-microglobulin (a.a. 20-203; A1M, Alpha-1 microglycoprotein, Complex-forming glycoprotein heterogeneous in charge, Protein HC) and Trypstatin (a.a. 284-344).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: P02760
Immunogen: Diphtheria toxoid-conjugated linear peptide corresponding to human bikunin N-terminal sequence.
Quantity: 100 μL
Research Discipline: Cell Structure
Gene ID (Entrez): NP_001624
Target Species: Human
Form: Serum
Antigen:
Bikunin (CP6)
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
AMBP, HCP, HI30, IATIL, ITIL, ITILC
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antiserum targets Inter-alpha-trypsin inhibitor light chain (a.a. 206-352; ITI-LC, Bikunin, EDC1, HI-30, Uronic-acid-rich protein) N-terminal sequence, it will also recognize the precursor protein AMBP (a.a. 1-352; alpha-1-microglobulin/bikunin precursor), but not the other two AMBP-derived products, Alpha-1-microglobulin (a.a. 20-203; A1M, Alpha-1 microglycoprotein, Complex-forming glycoprotein heterogeneous in charge, Protein HC) and Trypstatin (a.a. 284-344).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
P02760
Immunogen:
Diphtheria toxoid-conjugated linear peptide corresponding to human bikunin N-terminal sequence.
Quantity:
100 μL
Research Discipline:
Cell Structure
Gene ID (Entrez):
NP_001624
Target Species:
Human
Form:
Serum
Antigen: __
Classification: __
Conjugate: __
Gene: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Applications: __
Concentration: __
Formulation: __
Gene Accession No.: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __
Antigen:
__
Classification:
__
Conjugate:
__
Gene:
__
Host Species:
__
Purification Method:
__
Regulatory Status:
__
Primary or Secondary:
__
Test Specificity:
__
Content And Storage:
__
Applications:
__
Concentration:
__
Formulation:
__
Gene Accession No.:
__
Immunogen:
__
Quantity:
__
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
__
Form:
__
Antigen: Neurocan, C-terminal
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects Neurocan in fetal and adult rat brain.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Applications: Immunofluorescence, Immunohistochemistry, Immunoradiometric Assay
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antiserum with 0.02% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged recombinant fragment corresponding to 212 amino acids from the C-terminal half of rat Neurocan core protein.
Quantity: 25 μL
Research Discipline: Cell Structure
Gene ID (Entrez): __
Target Species: Mouse, Rat
Form: __
Antigen:
Neurocan, C-terminal
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects Neurocan in fetal and adult rat brain.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Applications:
Immunofluorescence, Immunohistochemistry, Immunoradiometric Assay
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antiserum with 0.02% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant fragment corresponding to 212 amino acids from the C-terminal half of rat Neurocan core protein.
Quantity:
25 μL
Research Discipline:
Cell Structure
Gene ID (Entrez):
__
Target Species:
Mouse, Rat
Form:
__
Antigen: Versican, Alpha Domain
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects versican in rat eye sections.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Immunohistochemistry (Paraffin), Immunoradiometric Assay, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged recombinant fragment corresponding to the first 321 amino acids of rat Versican.
Quantity: 25 μL
Research Discipline: Cell Structure
Gene ID (Entrez): __
Target Species: Rat
Form: Serum
Antigen:
Versican, Alpha Domain
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects versican in rat eye sections.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Immunohistochemistry (Paraffin), Immunoradiometric Assay, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged recombinant fragment corresponding to the first 321 amino acids of rat Versican.
Quantity:
25 μL
Research Discipline:
Cell Structure
Gene ID (Entrez):
__
Target Species:
Rat
Form:
Serum