ABS1531MI
MilliporeSigma™ AGS3/GPSM1, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1531MI-Each-of-1 | In Stock | ₹ 37,453.03 |
ABS1531MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,453.03
GST (18%): ₹ 6,741.545
Total Price: ₹ 44,194.575
Antigen
AGS3/GPSM1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
Gpsm1, Ags3
Host Species
Rabbit
Purification Method
Unpurified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antiserum immunostained predominantly renal collecting ducts of postnatal P12 ADPKD mice. Immunogen peptide blocking eliminated antibody stianing (Kwon, M., et al. (2012). Proc. Natl. Acad. Sci. U. S. A. 109(52):21462-21467). This antiserum targets a STK11/LKB1-interacting region sequence present in rat AGS3/GPSM1 isoform 1 and isoform 4 (isoform Long), 28% present in isoform 3 (Short-2), but completely absent from isoforms 2 (Short-1) reported by UniProt (Q9R080). Target sequence is also present in mouse isoforms 1, 3, 4, and 5, but absent from isoform 2 ( (UniProt Q6IR34).
Content And Storage
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications
Immunohistochemistry (Paraffin), Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.
Q9R080
Immunogen
Linear peptide corresponding to a sequence within the STK11/LKB1-interacting region of rat AGS3/GPSM1.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_653346
Target Species
Mouse
Form
Serum
Related Products
Description
- G-protein-signaling modulator 1 (UniProt Q9R080; also known as Activator of G-protein signaling 3) is encoded by the Gpsm1 (also known as Ags3) gene (Gene ID 246254) in rat species
- AGS3/GPSM1 is an evolutionarily conserved protein with four G-protein regulatory (GPR) GoLoco motifs (a.a
- 493-515, 546-568, 594-616, 628-650 of murine GPSM1) and functions as a guanine nucleotide dissociation inhibitor (GDI)
- GPSM1 increases heteromeric polycystin-1/polycystin-2 ion channel activity via Gβγ subunits
- GPSM1 is involved in regulating mitotic spindle orientation, cell polarity, and adenylyl cyclase activity
- GPSM1 plays a role in renal epithelial cell repair following renal injury and GPSM1 induction in polycystic kidney disease (PKD) and may be a critical modulator of the renal cystogenic process.
Compare Similar Items
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Antigen: AGS3/GPSM1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: Gpsm1, Ags3
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antiserum immunostained predominantly renal collecting ducts of postnatal P12 ADPKD mice. Immunogen peptide blocking eliminated antibody stianing (Kwon, M., et al. (2012). Proc. Natl. Acad. Sci. U. S. A. 109(52):21462-21467). This antiserum targets a STK11/LKB1-interacting region sequence present in rat AGS3/GPSM1 isoform 1 and isoform 4 (isoform Long), 28% present in isoform 3 (Short-2), but completely absent from isoforms 2 (Short-1) reported by UniProt (Q9R080). Target sequence is also present in mouse isoforms 1, 3, 4, and 5, but absent from isoform 2 ( (UniProt Q6IR34).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Immunohistochemistry (Paraffin), Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: Q9R080
Immunogen: Linear peptide corresponding to a sequence within the STK11/LKB1-interacting region of rat AGS3/GPSM1.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_653346
Target Species: Mouse
Form: Serum
Antigen:
AGS3/GPSM1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
Gpsm1, Ags3
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antiserum immunostained predominantly renal collecting ducts of postnatal P12 ADPKD mice. Immunogen peptide blocking eliminated antibody stianing (Kwon, M., et al. (2012). Proc. Natl. Acad. Sci. U. S. A. 109(52):21462-21467). This antiserum targets a STK11/LKB1-interacting region sequence present in rat AGS3/GPSM1 isoform 1 and isoform 4 (isoform Long), 28% present in isoform 3 (Short-2), but completely absent from isoforms 2 (Short-1) reported by UniProt (Q9R080). Target sequence is also present in mouse isoforms 1, 3, 4, and 5, but absent from isoform 2 ( (UniProt Q6IR34).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Immunohistochemistry (Paraffin), Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
Q9R080
Immunogen:
Linear peptide corresponding to a sequence within the STK11/LKB1-interacting region of rat AGS3/GPSM1.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_653346
Target Species:
Mouse
Form:
Serum
Antigen: VprBP
Classification: Polyclonal
Conjugate: Unconjugated
Gene: VPRBP, DCAF1, KIAA0800, RIP
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Specificity was verified by reduced target band detection upon shRNA-mediated VprBP knockdown in U2OS, WI-38/E6, HeLa, and HEK293T cells, as well as following cre expression in MEFs harboring floxed Vprbp alleles (McCall, C.M., et al. (2008). Mol. Cell. Biol. 28(18):5621-5633; Nakagawa, T., et al. (2015). 57(2):247-260). Target region is present in human spliced isoforms 1-4 as well as mouse isoforms 1 and 2 reported by UniProt (Q9Y4B6, Q80TR8), but missing in mouse isoforms 3 and 4 and not present in rat VprBP (NM_001191798.1 & NP_001178727.1).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q9Y4B6
Immunogen: KLH-conjugated linear peptide corresponding to human VprBP C-terminal end sequence.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_055518
Target Species: Human
Form: __
Antigen:
VprBP
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
VPRBP, DCAF1, KIAA0800, RIP
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Specificity was verified by reduced target band detection upon shRNA-mediated VprBP knockdown in U2OS, WI-38/E6, HeLa, and HEK293T cells, as well as following cre expression in MEFs harboring floxed Vprbp alleles (McCall, C.M., et al. (2008). Mol. Cell. Biol. 28(18):5621-5633; Nakagawa, T., et al. (2015). 57(2):247-260). Target region is present in human spliced isoforms 1-4 as well as mouse isoforms 1 and 2 reported by UniProt (Q9Y4B6, Q80TR8), but missing in mouse isoforms 3 and 4 and not present in rat VprBP (NM_001191798.1 & NP_001178727.1).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q9Y4B6
Immunogen:
KLH-conjugated linear peptide corresponding to human VprBP C-terminal end sequence.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_055518
Target Species:
Human
Form:
__
Antigen: Ribophorin I/RPN-I
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: __
Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
Gene Accession No.: P04843
Immunogen: KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Ribophorin I/RPN-I.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_002941
Target Species: Canine, Human, Rat
Form: Serum
Antigen:
Ribophorin I/RPN-I
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
__
Formulation:
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Accession No.:
P04843
Immunogen:
KLH-conjugated linear peptide corresponding to the C-terminal sequence of human Ribophorin I/RPN-I.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_002941
Target Species:
Canine, Human, Rat
Form:
Serum
Antigen: SR-alpha
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications: Immunoprecipitation, Western Blot
Concentration: __
Formulation: Rabbit polyclonal serum with 0.05% sodium azide.
Gene Accession No.: P08240
Immunogen: KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human SR-alpha.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_003130
Target Species: Canine, Human, Rat
Form: Serum
Antigen:
SR-alpha
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications:
Immunoprecipitation, Western Blot
Concentration:
__
Formulation:
Rabbit polyclonal serum with 0.05% sodium azide.
Gene Accession No.:
P08240
Immunogen:
KLH-conjugated linear peptide corresponding to an internal sequence within the N-terminal half of human SR-alpha.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_003130
Target Species:
Canine, Human, Rat
Form:
Serum