Thrombospondin-2 Mouse anti-Mouse, Unlabeled, Clone: 4, BD

Description

• Cell adhesion interactions involve large extracellular glycoproteins such as fibronectin, laminins, and thrombospondins
• The thrombospondins (TSPs), a small family of secreted glycoproteins, can be separated into two subfamilies based on structural similarity
• TSP-1 and TSP-2 are homotrimers of monomeric 145kDa chains, while TSP-3,4 and 5 are homopentamers of lower MW chains
• TSP-1 and TSP-2 interact with several of the same cell surface receptors and have been termed matricellular proteins
• However, the functional roles of TSP-1 and TSP-2 are poorly understood
• Study of TSP-2 deficient mice has shed some light on the functional role of this protein
• Although these mice appear normal, they in fact exhibit a wide variety of irregularities
• These include abnormal collagen fiber development which results in fragile skin and highly flexible tendons and ligaments
• They also exhibit increased cortical thickness in long bones and abnormal bleeding time
• These results, together with the developmental expression pattern of TSP-2, suggest that it functions as a modulator of the cell surface properties of mesenchymal cells which, in turn, affects cell functions such as adhesion and migration
• Host Species: Mouse Clone: 4 Isotype: IgG1 Species Reactivity: Mouse Immunogen: Human Thrombospondin-2 aa
• 173-295 Formula Weight [Chemical]: 200kDa Immunofluorescence, Western Blotting