MilliporeSigma™ anti-CD62E [ELAM-1] Clone: 1.2B6,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | CBL180IMI-Each-of-1 | In Stock | ₹ 38,734.72 |
CBL180IMI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
CD62E [ELAM-1]
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P16581\P16109
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This antibody is specific to human antigen E-selectin (ELAM-1, 115kDa) and P-selectin that are expressed on activated endothelial cells. The ligand is expressed on neutrophils and may function as an early part in neutrophil binding to the endothelium. This antibody inhibits neutrophil adhesion to E-selectin and P-selectin when used as F(ab')2 fragments. Although previously thought to recognize only human CD62E, later data (Goda, K., et al., (1999). Eur. J. Immunol. 29(5):1551-1560) showed that this antibody also recognizes human CD62P by binding to a common epitope on these members of the selectin family.
Content And Storage
-20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype
IgG1 κ
Applications
Functional Assay, ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Clone
1.2B6
Formulation
Purified mouse monoclonal IgG1κ antibody in PBS without preservatives.
Gene Symbols
SELE, ELAM, ELAM1, ESEL, SELP, GMRP, GMP140, GRMP, PSEL
Immunogen
TNF-activated human umbilical vein endothelial cells.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_000441\NP_002996
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects CD62E [ELAM-1] Clone: 1.2B6 in Human samples, and it is validated for Activity Assay, ELISA, Flow Cytometry, Immunohistochemistry, Western Blotting Selectins (CD62s) are single-chain transmembrane glycoproteins that function as cell adhesion molecules (CAMs) by interacting with a range of oligosaccharide structures including sialyl-Lewis X (sLeX) via their C-type lectin domain
- All three known selectins (L-, E-, and P-selectin or CD62L CD62E, CD62P, respectively) share a similar overall domain structure that includes an N-terminal C-type lectin domain (calcium-dependent lectin domain), an EGF-like domain, a variable number of short consensus repeat (SCR) or Sushi domains (2, 6, and 9 for CD62L CD62E, CD62P, respectively), a transmembrane domain, and a cytoplasmic tail
- The extracellular domains show a high homology among the three selectins, the transmembrane and cytoplasmic domains however are not conserved among the three
- E-selectin (CD62E, ELAM-1) and P-selectin (CD62P, GMP-140, LECAM3, PADGEM) are mainly expressed on endothelial cells at inflammatory sites, whereas L-selectin (CD62L) is exclusively expressed on leukocytes.
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Antigen: CD62E [ELAM-1]
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P16581\P16109
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This antibody is specific to human antigen E-selectin (ELAM-1, 115kDa) and P-selectin that are expressed on activated endothelial cells. The ligand is expressed on neutrophils and may function as an early part in neutrophil binding to the endothelium. This antibody inhibits neutrophil adhesion to E-selectin and P-selectin when used as F(ab')2 fragments. Although previously thought to recognize only human CD62E, later data (Goda, K., et al., (1999). Eur. J. Immunol. 29(5):1551-1560) showed that this antibody also recognizes human CD62P by binding to a common epitope on these members of the selectin family.
Content And Storage: -20°C for one year from date of shipment; Upon first thaw and prior to removing the cap centrifuge the vial and gently mix the solution; Aliquot into microcentrifuge tubes and store at −20°C; Avoid repeated freeze/thaw cycles
Isotype: IgG1 κ
Applications: Functional Assay, ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Clone: 1.2B6
Formulation: Purified mouse monoclonal IgG1κ antibody in PBS without preservatives.
Gene Symbols: SELE, ELAM, ELAM1, ESEL, SELP, GMRP, GMP140, GRMP, PSEL
Immunogen: TNF-activated human umbilical vein endothelial cells.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000441\NP_002996
Target Species: Human
Form: Purified
Antigen: Clathrin
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: NM_004859.3
Host Species: Mouse
Purification Method: __
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for up to 12 months.
Isotype: IgM
Applications: Immunohistochemistry, Western Blot
Clone: CHC5.9
Formulation: The antibody was purified by gel filtration and is presented as 100μg of lyophilysed material. Reconstitute with 1ml distilled water. Final buffer composition is PBS, pH 7.4.
Gene Symbols: CLTC, CHC17, CLTCL2, Hc, CLH17, CLH-17, KIAA0034
Immunogen: Coated vesicles (clathrin) of bovine brain.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Amphibian, Bovine, Human, Porcine, Rat
Form: Purified
Antigen: __
Classification: __
Conjugate: __
Gene Accession No.: __
Host Species: __
Purification Method: __
Regulatory Status: __
Primary or Secondary: __
Test Specificity: __
Content And Storage: __
Isotype: __
Applications: __
Clone: __
Formulation: __
Gene Symbols: __
Immunogen: __
Quantity: __
Research Discipline: __
Gene ID (Entrez): __
Target Species: __
Form: __