MAB348AF555
MilliporeSigma™ anti-APP A4 Alexa Fluor 555, Clone: 22C11,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MAB348AF555-Each-of-1 | In Stock | ₹ 59,902.27 |
MAB348AF555 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 59,902.27
GST (18%): ₹ 10,782.409
Total Price: ₹ 70,684.679
Antigen
APP A4
Classification
Monoclonal
Conjugate
Alexa Fluor 555
Gene Accession No.
P05067
Host Species
Mouse
Purification Method
Protein A purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 22C11 reacts with pre-A4. The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich, C., et al. (1993). J. Biol. Chem. 268(35):26571-26577). Clone 22C11 recognizes all three isoforms of APP, immature ∽110kDa, sAPP ∽120kDa, and mature ∽130kDa (Hoffmann, J., et al. (2000). Eur. J. Cell. Biol.79(12):905-914.). The antibody is known to cross react with APLP2 (Slunt, H.H., et al. (1994). J. Biol. Chem. 269(4):2637-2644).
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1
Applications
Immunocytochemistry
Clone
22C11
Formulation
Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
Gene Symbols
APP, A4, AD1
Immunogen
Purified recombinant Alzheimer precursor A4 (pre-A4695) fusion protein.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NM_201414, NM_000484.2, NM_201413.1
Target Species
Canine, Fish, Human, Monkey, Mouse, Porcine, Rat
Form
Purified
Related Products
Description
- Specifically detects APP A4 Clone: 22C11 in Canine, Fish, Human, Monkey, Mouse, Porcine, Rat samples, and it is validated for Immunocytochemistry Amyloid beta A4 protein (UniProt P05067; also known as ABPP, Alzheimer disease amyloid protein, Amyloid precursor protein, APP, APPI, Cerebral vascular amyloid peptide, CVAP, PN-II, PreA4, Protease nexin-II) is encoded by the APP (also known as A4, AD1) gene (Gene ID 351) in human
- Amyloid precursor protein (APP) is initially produced with a signal peptide sequence (a.a
- 1-17), the removal of which yields the mature protein with a large extracellular portion (a.a
- 18-699), followed by a transmembrane segment (a.a
- 700-723) and a cytoplasmic (a.a
- 724-770) tail
- APP can be further processed by the α-, β-, and γ-secretases in two alternative processing pathways
- In the non-amyloidogenic pathway, APP is first cleaved by the plasma membrane-localized α-secretase to generate an N-terminal extracellular sAPPα fragment (a.a
- 18-687) and a membrane-bound C-terminal fragment C83 (CTFα), which can be further cleaved by γ-secretase to produce a non-toxic small peptide p3 and a cytoplasmic APP intracellular domain (AICD)
- In the amyloidogenic pathway, APP undergoes β-cleavage in BACE-1 (β-site APP-cleaving enzyme)-enriched endosomes to generate an N-terminal extracellular sAPPβ fragment (a.a
- 18-671) and a membrane-bound C-terminal fragment C99 (CTFβ)
- Subsequent cleavage of C99 by γ-secretase releases the amyloid β peptide (Aβ) and AICD
- Aβ accumulation in the cortical and hippocampal regions of the brain is a major pathological feature of Alzheimer's disease (AD).
Compare Similar Items
Show Difference
Antigen: APP A4
Classification: Monoclonal
Conjugate: Alexa Fluor 555
Gene Accession No.: P05067
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 22C11 reacts with pre-A4. The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich, C., et al. (1993). J. Biol. Chem. 268(35):26571-26577). Clone 22C11 recognizes all three isoforms of APP, immature ∽110kDa, sAPP ∽120kDa, and mature ∽130kDa (Hoffmann, J., et al. (2000). Eur. J. Cell. Biol.79(12):905-914.). The antibody is known to cross react with APLP2 (Slunt, H.H., et al. (1994). J. Biol. Chem. 269(4):2637-2644).
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1
Applications: Immunocytochemistry
Clone: 22C11
Formulation: Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
Gene Symbols: APP, A4, AD1
Immunogen: Purified recombinant Alzheimer precursor A4 (pre-A4695) fusion protein.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NM_201414, NM_000484.2, NM_201413.1
Target Species: Canine, Fish, Human, Monkey, Mouse, Porcine, Rat
Form: Purified
Antigen:
APP A4
Classification:
Monoclonal
Conjugate:
Alexa Fluor 555
Gene Accession No.:
P05067
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 22C11 reacts with pre-A4. The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich, C., et al. (1993). J. Biol. Chem. 268(35):26571-26577). Clone 22C11 recognizes all three isoforms of APP, immature ∽110kDa, sAPP ∽120kDa, and mature ∽130kDa (Hoffmann, J., et al. (2000). Eur. J. Cell. Biol.79(12):905-914.). The antibody is known to cross react with APLP2 (Slunt, H.H., et al. (1994). J. Biol. Chem. 269(4):2637-2644).
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1
Applications:
Immunocytochemistry
Clone:
22C11
Formulation:
Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
Gene Symbols:
APP, A4, AD1
Immunogen:
Purified recombinant Alzheimer precursor A4 (pre-A4695) fusion protein.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NM_201414, NM_000484.2, NM_201413.1
Target Species:
Canine, Fish, Human, Monkey, Mouse, Porcine, Rat
Form:
Purified
Antigen: APP A4, a.a. 66-81 of APP {NT}
Classification: Monoclonal
Conjugate: Alexa Fluor 647
Gene Accession No.: P05067
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 22C11 reacts with pre-A4. The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich, C., et al. (1993). J. Biol. Chem. 268(35):26571-26577). Clone 22C11 recognizes all three isoforms of APP, immature ∽110kDa, sAPP ∽120kDa, and mature ∽130kDa (Hoffmann, J., et al. (2000). Eur. J. Cell. Biol.79(12):905-914.). The antibody is known to cross react with APLP2 (Slunt, H.H., et al. (1994). J. Biol. Chem. 269(4):2637-2644).
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1
Applications: Immunocytochemistry
Clone: 22C11
Formulation: Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
Gene Symbols: APP, A4, AD1
Immunogen: Purified recombinant Alzheimer precursor A4 (pre-A4695) fusion protein.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NM_201414, NM_000484.2, NM_201413.1
Target Species: Canine, Fish, Human, Monkey, Mouse, Porcine, Rat
Form: Purified
Antigen:
APP A4, a.a. 66-81 of APP {NT}
Classification:
Monoclonal
Conjugate:
Alexa Fluor 647
Gene Accession No.:
P05067
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 22C11 reacts with pre-A4. The antibody recognizes amino acids 66-81 of the N-terminus on the pre-A4 molecule (Hilbich, C., et al. (1993). J. Biol. Chem. 268(35):26571-26577). Clone 22C11 recognizes all three isoforms of APP, immature ∽110kDa, sAPP ∽120kDa, and mature ∽130kDa (Hoffmann, J., et al. (2000). Eur. J. Cell. Biol.79(12):905-914.). The antibody is known to cross react with APLP2 (Slunt, H.H., et al. (1994). J. Biol. Chem. 269(4):2637-2644).
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1
Applications:
Immunocytochemistry
Clone:
22C11
Formulation:
Purified mouse monoclonal IgG1 antibody conjugate in PBS with 15mg/mL BSA and 0.1 % sodium azide.
Gene Symbols:
APP, A4, AD1
Immunogen:
Purified recombinant Alzheimer precursor A4 (pre-A4695) fusion protein.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NM_201414, NM_000484.2, NM_201413.1
Target Species:
Canine, Fish, Human, Monkey, Mouse, Porcine, Rat
Form:
Purified
Antigen: Alzheimer Precursor Protein A4
Classification: Monoclonal
Conjugate: Biotin
Gene Accession No.: NP_000475
Host Species: Mouse
Purification Method: Protein A purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for one year
Isotype: IgG1
Applications: Immunocytochemistry, Immunohistochemistry
Clone: 22C11
Formulation: Purified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15mg/mL BSA.
Gene Symbols: APP, A4, AD1
Immunogen: Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Canine, Human, Monkey, Mouse, Porcine, Rat
Form: Purified
Antigen:
Alzheimer Precursor Protein A4
Classification:
Monoclonal
Conjugate:
Biotin
Gene Accession No.:
NP_000475
Host Species:
Mouse
Purification Method:
Protein A purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for one year
Isotype:
IgG1
Applications:
Immunocytochemistry, Immunohistochemistry
Clone:
22C11
Formulation:
Purified mouse monoclonal IgG1 conjugated to Biotin in PBS with 0.1% sodium azide and 15mg/mL BSA.
Gene Symbols:
APP, A4, AD1
Immunogen:
Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Canine, Human, Monkey, Mouse, Porcine, Rat
Form:
Purified
Antigen: APP A4
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: NM_000484.2; NM_201413.1; NM_201414.1
Host Species: Mouse
Purification Method: Protein A purfied
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype: IgG1
Applications: Immunofluorescence, Immunohistochemistry, Western Blot
Clone: 22C11
Formulation: Protein A Purified mouse immunoglobulin in 20mM sodium phosphate, 250mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Gene Symbols: APP, PN-II, AD1, ABETA, CTFgamma, APPI, ABPP, A4, CVAP, PN2, PreA4, AAA
Immunogen: Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.
Quantity: 50 μg
Research Discipline: __
Gene ID (Entrez): __
Target Species: Canine, Fish, Human, Monkey, Mouse, Porcine, Rat
Form: Purified
Antigen:
APP A4
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
NM_000484.2; NM_201413.1; NM_201414.1
Host Species:
Mouse
Purification Method:
Protein A purfied
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype:
IgG1
Applications:
Immunofluorescence, Immunohistochemistry, Western Blot
Clone:
22C11
Formulation:
Protein A Purified mouse immunoglobulin in 20mM sodium phosphate, 250mM NaCl, pH. 7.6, with 0.1% sodium azide as a preservative.
Gene Symbols:
APP, PN-II, AD1, ABETA, CTFgamma, APPI, ABPP, A4, CVAP, PN2, PreA4, AAA
Immunogen:
Purified recombinant Alzheimer precursor A4 (pre A4695) fusion protein.
Quantity:
50 μg
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Canine, Fish, Human, Monkey, Mouse, Porcine, Rat
Form:
Purified