MABC609MI
MilliporeSigma™ Mouse anti-Thymidylate Kinase/TMPK, Clone: 1A5.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABC609MI-Each-of-1 | In Stock | ₹ 41,307.51 |
MABC609MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
Thymidylate Kinase/TMPK
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
DTYMK; CDC8; TMPK; TYMK
Immunogen
GST-tagged recombinant protein corresponding to human Thymidylate Kinase/TMPK.
Quantity
100 μg
Research Discipline
Apoptosis, Cancer
Gene ID (Entrez)
NP_001158503
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG2a κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
1A5.1
Gene Accession No.
P23919
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects Thymidylate Kinase/TMPK clone: 1A5.1 in Human samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Thymidylate kinase (EC 2.7.4.9; UniProt P23919; also known as dTMP kinase) is encoded by the DTYMK (also known as CDC8, PP3731, TMPK, TYMK) gene (Gene ID 1841) in human
- Thymidylate kinase (TMPK) is an ubiquitously expressed enzyme of the dTTP synthesis pathway involved in DNA synthesis
- TMPK catalyzes the phosphorylation of thymidine 5'-monophosphate (dTMP) in the presence of ATP and Mg 2+ to form thymidine 5'-diphosphate (dTDP), which is then further phosphorylated by nucleoside-diphosphate kinase (NDK) to thymidine 5'-triphosphate (dTTP)
- Aside from its normal physiological role, TMPK activity is essential for the activation of nucleoside analogs-based prodrugs, such as the clinically used anti-HIV prodrugs AZT and d4T, which need to be converted to the triphosphate forms for their pharmacological activities
- Inhibition of TMPK activity is reported to augment the potency of anticancer agent doxorubicin against human colon cancer cells regardless of their p53 status
- In addition, lung cancers with LKB1-mutations are reported to show deficits in nucleotide metabolism and exhibit hypersensitivity to DTYMK inhibition.
Compare Similar Items
Show Difference
Antigen: Thymidylate Kinase/TMPK
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: DTYMK; CDC8; TMPK; TYMK
Immunogen: GST-tagged recombinant protein corresponding to human Thymidylate Kinase/TMPK.
Quantity: 100 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_001158503
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 1A5.1
Gene Accession No.: P23919
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Thymidylate Kinase/TMPK
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
DTYMK; CDC8; TMPK; TYMK
Immunogen:
GST-tagged recombinant protein corresponding to human Thymidylate Kinase/TMPK.
Quantity:
100 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_001158503
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
1A5.1
Gene Accession No.:
P23919
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: B7-H6
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: NCR3LG1; B7H6
Immunogen: Recombinant protein corresponding to the extracellular domain of human B7-H6.
Quantity: 100 μg
Research Discipline: Apoptosis, Cancer
Gene ID (Entrez): NP_001189368
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Flow Cytometry
Clone: 5.51.18
Gene Accession No.: Q68D85
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
B7-H6
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
NCR3LG1; B7H6
Immunogen:
Recombinant protein corresponding to the extracellular domain of human B7-H6.
Quantity:
100 μg
Research Discipline:
Apoptosis, Cancer
Gene ID (Entrez):
NP_001189368
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Flow Cytometry
Clone:
5.51.18
Gene Accession No.:
Q68D85
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: NOX4
Classification: Monoclonal
Formulation: Mouse monoclonal IgG2bκ hybridoma culture supernatant without preservatives.
Gene Symbols: __
Immunogen: GST-tagged recombinant protein corresponding to a fragment from the third extracellular loop of human NOX4.
Quantity: 100 μL
Research Discipline: Apoptosis & Cancer
Gene ID (Entrez): NP_001137308
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG2b κ
Applications: Western Blot
Clone: 10A8.1
Gene Accession No.: Q9NPH5
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Culture Supernatant
Antigen:
NOX4
Classification:
Monoclonal
Formulation:
Mouse monoclonal IgG2bκ hybridoma culture supernatant without preservatives.
Gene Symbols:
__
Immunogen:
GST-tagged recombinant protein corresponding to a fragment from the third extracellular loop of human NOX4.
Quantity:
100 μL
Research Discipline:
Apoptosis & Cancer
Gene ID (Entrez):
NP_001137308
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG2b κ
Applications:
Western Blot
Clone:
10A8.1
Gene Accession No.:
Q9NPH5
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Culture Supernatant
Antigen: KLF4
Classification: Monoclonal
Formulation: Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Gene Symbols: EZF, GKLF, KLF4
Immunogen: Purified recombinant fragment of human KLF4 expressed in E. coli.
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: −20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype: IgG1
Applications: Immunohistochemistry, Western Blot
Clone: 1E06
Gene Accession No.: NP_004226
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Ascites
Antigen:
KLF4
Classification:
Monoclonal
Formulation:
Mouse monoclonal IgG1 ascitic fluid containing up to 0.1% sodium azide.
Gene Symbols:
EZF, GKLF, KLF4
Immunogen:
Purified recombinant fragment of human KLF4 expressed in E. coli.
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
−20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype:
IgG1
Applications:
Immunohistochemistry, Western Blot
Clone:
1E06
Gene Accession No.:
NP_004226
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Ascites