MABD396
MilliporeSigma™ Mouse anti-Sortilin, Clone: 4E3.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABD396-Each-of-1 | In Stock | ₹ 38,734.72 |
MABD396 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
Sortilin
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
SORT1; LDLCQ6; NT3
Immunogen
GST-tagged recombinant human Sortilin C-terminal fragment.
Quantity
100 μg
Research Discipline
Stem Cell Research
Gene ID (Entrez)
NP_002950
Content And Storage
Stable for one year at 2°C to 8°C from date of receipt.
Isotype
IgG1 κ
Applications
Immunohistochemistry (Paraffin), Western Blot
Clone
4E3.1
Gene Accession No.
Q99523
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Mouse
Form
Purified
Related Products
Description
- Specifically detects Sortilin clone: 4E3.1 in Human, Mouse samples, and it is validated for Immunohistochemistry (Paraffin), Western Blotting Sortilin (UniProt Q99523; also known as 100kDa NT receptor, Glycoprotein 95, Gp95, Neurotensin receptor 3, NT3, NTR3) is encoded by the SORT1 (also known as LDLCQ6, NT3) gene (Gene ID 6272) in human
- Sortlin belongs to the a family of sorting receptors characterized by the Vps10p domain that creates a tunnel cavity with its ten-bladed β-propeller for the binding of soluble ligands
- The family members also contain a short cytoplasmic tail that harbors recognition motifs for subcellular sorting adaptor proteins
- Sortilin is reproted to bind PCSK9 in the trans-Golgi network with high-affinity in HepG2 cells
- Sort1 knockout mice exhibit reduced PCSK9 plasma concentration and altered PCSK9 subcellular localization in hepatocytes
- Sortilin is also found to colocalize with APP in neurites and facilitates APP processing toward the production of sAPPα, possibly by optimizing APP as a substrate for α-secretase cleavage
- Sortilin is initially produced with a signal peptide (a.a
- 1-33) and a propeptide (a.a
- 34-77) sequence, the removal of which yields the mature receptor (a.a
- 78-831) with a large luminal/extracellular (a.a
- 78-555) portion, a transmembrane region (a.a
- 756-778), and a short cytoplasmic tail (a.a.779-831)
- Similar to the other two family members (MPRs and SorLA), sortilin resides both on the membrane of intracellular vesicles and on the plasma membrane
- Altered sortilin expressions due to SORT1 genetic variations affect serum levels of low density lipoprotein cholesterol (LDL-C) and contribute to the LDL-C level quantitative trait locus 6 (LDLCQ6) and susceptibility to myocardial infarction.
Compare Similar Items
Show Difference
Antigen: Sortilin
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: SORT1; LDLCQ6; NT3
Immunogen: GST-tagged recombinant human Sortilin C-terminal fragment.
Quantity: 100 μg
Research Discipline: Stem Cell Research
Gene ID (Entrez): NP_002950
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 4E3.1
Gene Accession No.: Q99523
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
Sortilin
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
SORT1; LDLCQ6; NT3
Immunogen:
GST-tagged recombinant human Sortilin C-terminal fragment.
Quantity:
100 μg
Research Discipline:
Stem Cell Research
Gene ID (Entrez):
NP_002950
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
4E3.1
Gene Accession No.:
Q99523
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Antigen: DAX-1
Classification: Monoclonal
Formulation: Mouse monoclonal IgG1κ Ascites with 0.05% sodium azide.
Gene Symbols: NR0B1, DAX1, AHC
Immunogen: Linear peptide corresponding to Human DAX-1 (amino acids 135-166).
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: −20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Western Blot
Clone: 2F4
Gene Accession No.: NP_000466
Host Species: Mouse
Purification Method: Unpurified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Ascites
Antigen:
DAX-1
Classification:
Monoclonal
Formulation:
Mouse monoclonal IgG1κ Ascites with 0.05% sodium azide.
Gene Symbols:
NR0B1, DAX1, AHC
Immunogen:
Linear peptide corresponding to Human DAX-1 (amino acids 135-166).
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
−20°C in undiluted aliquots for up to 12 months. Avoid repeated freeze/thaw cycles.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Western Blot
Clone:
2F4
Gene Accession No.:
NP_000466
Host Species:
Mouse
Purification Method:
Unpurified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Ascites
Antigen: Neuroblasts
Classification: Monoclonal
Formulation: Purified Armenian hamster monoclonal antibody in PBS without preservatives.
Gene Symbols: __
Immunogen: E13.5 FVB mouse embryo olfactory bulb-derived neurospheres (Del Valle, I., et al. (2010). Neuroscience. 169(3):1473-1485).
Quantity: 100 μg
Research Discipline: Stem Cell Research
Gene ID (Entrez): __
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: __
Applications: Immunohistochemistry, Immunoprecipitation, Inhibition Assays, Radioimmune Assays (RIA), Western Blot
Clone: Nilo2
Gene Accession No.: __
Host Species: Armenian Hamster
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Mouse
Form: Purified
Antigen:
Neuroblasts
Classification:
Monoclonal
Formulation:
Purified Armenian hamster monoclonal antibody in PBS without preservatives.
Gene Symbols:
__
Immunogen:
E13.5 FVB mouse embryo olfactory bulb-derived neurospheres (Del Valle, I., et al. (2010). Neuroscience. 169(3):1473-1485).
Quantity:
100 μg
Research Discipline:
Stem Cell Research
Gene ID (Entrez):
__
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
__
Applications:
Immunohistochemistry, Immunoprecipitation, Inhibition Assays, Radioimmune Assays (RIA), Western Blot
Clone:
Nilo2
Gene Accession No.:
__
Host Species:
Armenian Hamster
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Mouse
Form:
Purified
Antigen: SIP1
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG2aκ supernatant in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B, HRIHFB2411
Immunogen: His-tagged recombinant protein corresponding to the N-terminus of Human SIP1.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: 2-8°C for one year
Isotype: IgG2a κ
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: 6E5
Gene Accession No.: NP_001165124
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
SIP1
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG2aκ supernatant in buffer containing 0.1MTris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
ZEB2, KIAA0569, SIP1, ZFHX1B, ZFX1B, HRIHFB2411
Immunogen:
His-tagged recombinant protein corresponding to the N-terminus of Human SIP1.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
2-8°C for one year
Isotype:
IgG2a κ
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
6E5
Gene Accession No.:
NP_001165124
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified