MABE1045MI

MilliporeSigma™ CTIP2/BCL11B, Rat, Unlabeled, Clone: 25B6,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABE1045MI-Each-of-1 In Stock ₹ 41,643.76

MABE1045MI - Each of 1

₹ 41,643.76

In Stock

Quantity

1

Base Price: ₹ 41,643.76

GST (18%): ₹ 7,495.877

Total Price: ₹ 49,139.637

Antigen

CTIP2/BCL11B

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Purified rat monoclonal antibody IgG2a in buffer containing 150mM NaCl, 15mM HEPES, pH 7.5, with 0.02% Sodium Azide.

Gene Accession No.

Q99PV8

Immunogen

GST-tagged recombinant full-length mouse CTIP2 Beta isoform (Senawong, T., et al. (2003). J. Biol. Chem. 278(44):43041-43050).

Quantity

100 μg

Research Discipline

Epigenetics & Nuclear Function

Gene ID (Entrez)

NP_067374

Target Species

Human

Form

Purified

Applications

Western Blot

Clone

25B6

Conjugate

Unconjugated

Gene

Bcl11b, Ctip2, Rit1

Host Species

Rat

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Clone 25B6 recognizes both the Alpha and Beta spliced isoforms of human and mouse CTIP2/BCL11B.

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Isotype

IgG2a

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Description

  • B-cell lymphoma/leukemia 11B (UniProt Q99PV8; also known as B-cell CLL/lymphoma 11B, BCL-11B, COUP-TF-interacting protein 2, mRit1, Radiation-induced tumor suppressor gene 1 protein) is encoded by the Bcl11b (also known as Ctip2, Rit1) gene (Gene ID 58208) in murine species
  • CTIP2/CBL11B is a C2H2 zinc finger protein that binds GC-rich response elements and is reported to associate with a variety of cofactors, including the corepressor complexes NuRD, Sirt1, histone acetyltransferase (HAT) p300, functioning both as a transcriptional repressor and activator
  • CTIP2/CBL11B is required at multiple developmental checkpoints for T cell commitment and maintenance
  • CTIP2/CBL11B expression is initiated at double-negative 2 (DN2) stage of T cell development and is maintained in mature T lymphocytes, with lower levels found in NK cells, but not in B cells, myeloid or dendritic cells
  • Bcl11b-/- mice die shortly after birth due to a blockade of thymocyte development at the DN2 stage
  • Bcl11b-deficient DN2 thymocytes are highly proliferative and retain the potential to differentiate into NK cells and myeloid lineages, but not mature T-cells.

Compare Similar Items

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MilliporeSigma™

MABE1045MI

--


Antigen:
CTIP2/BCL11B

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified rat monoclonal antibody IgG2a in buffer containing 150mM NaCl, 15mM HEPES, pH 7.5, with 0.02% Sodium Azide.

Gene Accession No.:
Q99PV8

Immunogen:
GST-tagged recombinant full-length mouse CTIP2 Beta isoform (Senawong, T., et al. (2003). J. Biol. Chem. 278(44):43041-43050).

Quantity:
100 μg

Research Discipline:
Epigenetics & Nuclear Function

Gene ID (Entrez):
NP_067374

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
25B6

Conjugate:
Unconjugated

Gene:
Bcl11b, Ctip2, Rit1

Host Species:
Rat

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone 25B6 recognizes both the Alpha and Beta spliced isoforms of human and mouse CTIP2/BCL11B.

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG2a

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MABE1052MI

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Antigen:
GMPS

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
P49915

Immunogen:
GST-tagged recombinant human GMPS ATP-PPase domain fragment.

Quantity:
100 μL

Research Discipline:
Epigenetics & Nuclear Function

Gene ID (Entrez):
NP_003866

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
1G6.1

Conjugate:
Unconjugated

Gene:
GMPS

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone 1G6.1 targets an epitope within the GMPS ATP-PPase domain region present in both spliced isoforms of human GMPS reported by UniProt (P49915).

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG1 κ

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MABE1060MI

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Antigen:
CtIP

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
__

Gene Accession No.:
__

Immunogen:
GST-tagged recombinant fragment corresponding to 278 amino acids from the C-terminal half of human CtBP-interacting protein.

Quantity:
100 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_002885.1

Target Species:
Mouse, Human

Form:
Purified

Applications:
Western Blot, Immunocytochemistry, Immunoprecipitation

Clone:
14-1

Conjugate:
Unconjugated

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone 14-1 specifically detects CtBP-interacting protein in HEK293 cells.

Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.

Isotype:
IgG1 κ

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MABE1067100

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Antigen:
ESET (SETDB1)

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal antibody IgG1 in PBS with 0.01% sodium azide.

Gene Accession No.:
__

Immunogen:
His-tagged recombinant fragment corresponding to 213 amino acids from the internal region of murine SETDB1.

Quantity:
100 μg

Research Discipline:
Epigenetics & Nuclear Function

Gene ID (Entrez):
__

Target Species:
Mouse

Form:
Purified

Applications:
ChIP Assay, Immunoprecipitation, Western Blot

Clone:
F0808

Conjugate:
Unconjugated

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone F0808 specifically detects Histone-lysine N-methyltransferase SETDB1. It targets an epitope with in the internal region.

Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.

Isotype:
IgG1 κ