MABF983MI
MilliporeSigma™ Mouse anti-Complement C3b/iC3b/C3dg, Clone: 1H8,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABF983MI-Each-of-1 | In Stock | ₹ 41,307.51 |
MABF983MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
Complement C3b/iC3b/C3dg
Classification
Monoclonal
Formulation
Purified mouse monoclonal IgG2aκ antibody in buffer containing PBS without preservatives.
Gene Symbols
C3; CPAMD1
Immunogen
Sepharose 4B beads with surface C3b/C3bi deposits via APC in normal human serum corresponding to the iC3dg of human Complement C3b/iC3b/C3dg.
Quantity
100 μg
Research Discipline
Inflammation and Immunology
Gene ID (Entrez)
NP_000055
Content And Storage
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype
IgG2a κ
Applications
Flow Cytometry
Clone
1H8
Gene Accession No.
P01024
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human, Primate
Form
Purified
Related Products
Description
- Specifically detects Complement C3b/iC3b/C3dg clone: 1H8 in Human, Primate samples, and it is validated for Flow Cytometry Complement C3 (UniProt P01024; also known as C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1) is encoded by the C3 (also known as CPAMD1) gene (Gene ID 718) in human
- C3 is initially translated with an N-terminal 22-amino acid signal peptide sequence, which is then removed to produce the 1641-amino acid mature C3
- It plays a central role in the activation of complement system
- Its activation is required for the activation of both classical and alternative pathway of complement (CPC and APC, respectively)
- C3 is cleaved into C3a and C3b during CPC activation by the C3-convertase C4b2a composed of the activated C4 and C2
- In APC, C3 is cleaved by the C3-convertase C3bBb composed C3b and the activated form of factor B (Bb)
- C3b serves as an opsonizing agent, and can be further cleaved by Factor I into C3c and C3d
- iC3b is a proteolytically inactive C3b fragment that still opsonizes target microbes or cells, but cannot further amplify/activate the complement cascade through APC
- iC3b can be further cleaved to C3dg, and finally to C3d
- Unregulated activation of APC can result in paroxysmal nocturnal hemoglobinuria (PNH) that is characterized by chronic intravascular hemolysis
- Clinical C5-neutralizing mAb treatment prevents the formation of cytolytic membrane attack complex (MAC) of complement, but does not block APC activation
- Consequently, PNH patients are left with immune-mediated hemolytic anemia and their erythrocytes become opsonized with complement C3
- Monoclonal antibodies (mAbs) against C3b/iC3b are useful for monitoring and studying C3b/iC3b deposit on PNH blood cells and mAbs with neutralizing activities are useful tools for studying C3-mediated CPC and APC.
Compare Similar Items
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Antigen: Complement C3b/iC3b/C3dg
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing PBS without preservatives.
Gene Symbols: C3; CPAMD1
Immunogen: Sepharose 4B beads with surface C3b/C3bi deposits via APC in normal human serum corresponding to the iC3dg of human Complement C3b/iC3b/C3dg.
Quantity: 100 μg
Research Discipline: Inflammation and Immunology
Gene ID (Entrez): NP_000055
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype: IgG2a κ
Applications: Flow Cytometry
Clone: 1H8
Gene Accession No.: P01024
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human, Primate
Form: Purified
Antigen:
Complement C3b/iC3b/C3dg
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing PBS without preservatives.
Gene Symbols:
C3; CPAMD1
Immunogen:
Sepharose 4B beads with surface C3b/C3bi deposits via APC in normal human serum corresponding to the iC3dg of human Complement C3b/iC3b/C3dg.
Quantity:
100 μg
Research Discipline:
Inflammation and Immunology
Gene ID (Entrez):
NP_000055
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype:
IgG2a κ
Applications:
Flow Cytometry
Clone:
1H8
Gene Accession No.:
P01024
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human, Primate
Form:
Purified
Antigen: Eosinophil Cationic Protein
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG1 antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: Purified human ECP.
Quantity: 100 μg
Research Discipline: Inflammation & Immunology
Gene ID (Entrez): NP_002926
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1
Applications: Immunohistochemistry (Paraffin), Immunoassay, Western Blot
Clone: 1C8.5/D8
Gene Accession No.: P12724
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
Eosinophil Cationic Protein
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG1 antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
Purified human ECP.
Quantity:
100 μg
Research Discipline:
Inflammation & Immunology
Gene ID (Entrez):
NP_002926
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1
Applications:
Immunohistochemistry (Paraffin), Immunoassay, Western Blot
Clone:
1C8.5/D8
Gene Accession No.:
P12724
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: Amyloid β
Classification: Monoclonal
Formulation: Purified mouse monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4, 150mM NaCl) with 0.05% sodium azide.
Gene Symbols: APP, A4, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, PreA4
Immunogen: Human Amyloid β peptide
Quantity: 50 μg
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: 2-8°C for one year
Isotype: IgG2a κ
Applications: ELISA, Immunohistochemistry, Western Blot
Clone: WO2
Gene Accession No.: NP_000475
Host Species: Mouse
Purification Method: Protein G purfied
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human, Mouse
Form: Purified
Antigen:
Amyloid β
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal IgG2aκ in buffer containing 0.1MTris-Glycine (pH 7.4, 150mM NaCl) with 0.05% sodium azide.
Gene Symbols:
APP, A4, AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, PreA4
Immunogen:
Human Amyloid β peptide
Quantity:
50 μg
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
2-8°C for one year
Isotype:
IgG2a κ
Applications:
ELISA, Immunohistochemistry, Western Blot
Clone:
WO2
Gene Accession No.:
NP_000475
Host Species:
Mouse
Purification Method:
Protein G purfied
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human, Mouse
Form:
Purified
Antigen: SRY
Classification: Monoclonal
Formulation: Purified mouse monoclonal in PBS containing up to 0.1% sodium azide and 0.5% protein stabilizer.
Gene Symbols: SRY, TDF
Immunogen: Purified recombinant fragment of human SRY expressed in E. Coli
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Content And Storage: 2-8°C for one year
Isotype: IgG1
Applications: ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Clone: 1G4
Gene Accession No.: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: __
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
SRY
Classification:
Monoclonal
Formulation:
Purified mouse monoclonal in PBS containing up to 0.1% sodium azide and 0.5% protein stabilizer.
Gene Symbols:
SRY, TDF
Immunogen:
Purified recombinant fragment of human SRY expressed in E. Coli
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Content And Storage:
2-8°C for one year
Isotype:
IgG1
Applications:
ELISA, Flow Cytometry, Immunohistochemistry, Western Blot
Clone:
1G4
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
__
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified