MABN1790MI
MilliporeSigma™ C9ORF72/C9RANT (poly-AP), Rat, Unlabeled, Clone: 14E2,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1790MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABN1790MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
C9ORF72/C9RANT (poly-AP)
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rat monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q96LT7
Immunogen
Recombinant GST fusion with a 10 AP-repeat sequence (GST-AP10).
Quantity
100 μg
Research Discipline
Neuroscience
Test Specificity
Clone 14E2 recognizes C9ORF72/C9RANT (poly-AP) and other proteins containing poly-AP (poly-PA) sequence.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Applications
Western Blot
Clone
14E2
Conjugate
Unconjugated
Gene
C9orf72, ALSFTD, FTDALS
Host Species
Rat
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Target Species
Human
Form
Purified
Related Products
Description
- Expansion of a GGGGCC hexanucleotide repeat sequence in the non-coding region of human chromosome 9 open reading frame 72 or C9orf72 (also known as ALSFTD, FTDALS; Gene ID 203228) is the most common genetic abnormality in familial and sporadic frontotemporal dementia (FTD) and motor neuron disease (MND), with amyotrophic lateral sclerosis (ALS) as the most frequent form
- The number of hexanucleotide repeats in the normal population ranges from 2 to 24, whereas up to several thousand repeats (700 - 4,400 repeats) are found in the pathologically expanded allele
- Unconventional repeat-associated non-ATG-initiated translation (RANT) of the GGGGCC repeats in the three alternate reading frames from both sense and antisense transcripts generates five types of dipeptide repeat (DPR) protein species, each composed of repeating units of two amino acids, glycine-alanine (GA), glycine-proline (GP), glycine-arginine (GR), alanine-proline (AP), proline-arginine (PR), respectively
- Immunofluorescence localization of exogenously epxressed DPR-GFP fusions in HEK293 transfectants showed dot-like or star-shaped poly-GA inclusions with predominant cytoplasmic and occasional nuclear localization, while poly-GR and poly-PR showed large dot-like intranuclear inclusions and occasional smaller cytoplasmic inclusions
- In contrast, poly-PA was evenly distributed throughout the nucleus and cytoplasm without apparent aggregation.
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Antigen: C9ORF72/C9RANT (poly-AP)
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rat monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q96LT7
Immunogen: Recombinant GST fusion with a 10 AP-repeat sequence (GST-AP10).
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: Clone 14E2 recognizes C9ORF72/C9RANT (poly-AP) and other proteins containing poly-AP (poly-PA) sequence.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot
Clone: 14E2
Conjugate: Unconjugated
Gene: C9orf72, ALSFTD, FTDALS
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
C9ORF72/C9RANT (poly-AP)
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rat monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q96LT7
Immunogen:
Recombinant GST fusion with a 10 AP-repeat sequence (GST-AP10).
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
Clone 14E2 recognizes C9ORF72/C9RANT (poly-AP) and other proteins containing poly-AP (poly-PA) sequence.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
14E2
Conjugate:
Unconjugated
Gene:
C9orf72, ALSFTD, FTDALS
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: SorLA
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q92673
Immunogen: Recombinant human SorLA extracellular/luminal domain.
Quantity: 100 μg
Research Discipline: Neuroscience
Test Specificity: Clone 20C11 immunostained SorLA endocytic vesicles in wild-type, but not Sorl1-/-, mouse astrocytes.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Western Blot
Clone: 20C11
Conjugate: Unconjugated
Gene: SORL1, C11orf32
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
SorLA
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q92673
Immunogen:
Recombinant human SorLA extracellular/luminal domain.
Quantity:
100 μg
Research Discipline:
Neuroscience
Test Specificity:
Clone 20C11 immunostained SorLA endocytic vesicles in wild-type, but not Sorl1-/-, mouse astrocytes.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Western Blot
Clone:
20C11
Conjugate:
Unconjugated
Gene:
SORL1, C11orf32
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
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