MABS1235MI
MilliporeSigma™ anti-Progesterone Receptor A/B Clone: 488/H3,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1235MI-Each-of-1 | In Stock | ₹ 44,990.87 |
MABS1235MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 44,990.87
GST (18%): ₹ 8,098.357
Total Price: ₹ 53,089.227
Antigen
Progesterone Receptor A/B
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
P06401
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 488/H3 reacts with both isoform 1 (isoform B; PR-B) and isoform 2 (isoform A; PR-A). This clone is also expected to react with isoform 5 (delta4), but not isoform 3 or 4 (PR-M).
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Applications
Immunocytochemistry, Western Blot
Clone
488/H3
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
PGR, NR3C3
Immunogen
Recombinant protein corresponding to the N-terminal half fragment of human Progesterone Receptor B.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001189403 and NP_000917
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects Progesterone Receptor A/B Clone: 488/H3 in Human samples, and it is validated for Immunocytochemistry, Western Blotting Progesterone receptor (UniProt P06401; also known as nuclear receptor subfamily 3 group C member 3, PR) is encoded by the PGR (also known as NR3C3) gene (Gene ID 5241) in human
- The progesterone receptor (PR) is a hormone activated transcription factor, where hormone binding triggers the dissociation of heat shock and chaperone proteins from PR, leading to PR dimerization and activation
- The receptor dimer then binds progestin response elements in the regulatory regions of its target genes and a multi-component complex is assembled to enable transcription
- In addition, a number of kinases are reported to regulate PR activity via phosphorylation
- PR can also regulate transcription without direct DNA binding by tethering to other transcription factors, such as specificity protein 1 (Sp1) or activator protein 1 (AP-1), and modulating their transcriptional activity on target genes
- PR is expressed as five isoforms, including PR-B and PR-A that are produced as a result of alternate estrogen inducible promoters within the same PGR gene
- PR-A lacks the first 164 amino acids of PR-B, but the two isoforms have otherwise identical sequence
- PR-B and PR-A can regulate distinct subsets of target genes and studies in knockout mice suggest that PR-B predominantly regulates mammary gland development and PR-A is critical for normal uterine function.
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Antigen: Progesterone Receptor A/B
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P06401
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 488/H3 reacts with both isoform 1 (isoform B; PR-B) and isoform 2 (isoform A; PR-A). This clone is also expected to react with isoform 5 (delta4), but not isoform 3 or 4 (PR-M).
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Applications: Immunocytochemistry, Western Blot
Clone: 488/H3
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: PGR, NR3C3
Immunogen: Recombinant protein corresponding to the N-terminal half fragment of human Progesterone Receptor B.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001189403 and NP_000917
Target Species: Human
Form: Purified
Antigen:
Progesterone Receptor A/B
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P06401
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 488/H3 reacts with both isoform 1 (isoform B; PR-B) and isoform 2 (isoform A; PR-A). This clone is also expected to react with isoform 5 (delta4), but not isoform 3 or 4 (PR-M).
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Western Blot
Clone:
488/H3
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
PGR, NR3C3
Immunogen:
Recombinant protein corresponding to the N-terminal half fragment of human Progesterone Receptor B.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001189403 and NP_000917
Target Species:
Human
Form:
Purified
Antigen: NKCC1/2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: P55011
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone T4 recognizes both NKCC1 and NKCC2 by targeting a C-terminal region epitope exposed only under denaturing condition, and unaccessible for antibody binding when NKCC assumes its native conformation (Lytle, C., et al. (1995). Am. J. Physiol. 269(6 Pt 1):C1469-C1505).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Clone: T4
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols: __
Immunogen: Recombinant human NKCC1 C-terminal fragment.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001037.1
Target Species: Avian
Form: Purified
Antigen:
NKCC1/2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
P55011
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone T4 recognizes both NKCC1 and NKCC2 by targeting a C-terminal region epitope exposed only under denaturing condition, and unaccessible for antibody binding when NKCC assumes its native conformation (Lytle, C., et al. (1995). Am. J. Physiol. 269(6 Pt 1):C1469-C1505).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Immunocytochemistry, Immunofluorescence, Immunoprecipitation, Western Blot
Clone:
T4
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Symbols:
__
Immunogen:
Recombinant human NKCC1 C-terminal fragment.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001037.1
Target Species:
Avian
Form:
Purified
Antigen: CYP2J2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 6-5-20-8 detects cytochrome p450 2J2 in human and murine species.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype: IgG1 κ
Applications: Western Blot, Inhibition Assays
Clone: 6-5-20-8
Formulation: __
Gene Symbols: CYP2J2
Immunogen: A full-length recombinant human cytochrome P450 2J2.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_000766
Target Species: Mouse, Human
Form: Purified
Antigen:
CYP2J2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 6-5-20-8 detects cytochrome p450 2J2 in human and murine species.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Isotype:
IgG1 κ
Applications:
Western Blot, Inhibition Assays
Clone:
6-5-20-8
Formulation:
__
Gene Symbols:
CYP2J2
Immunogen:
A full-length recombinant human cytochrome P450 2J2.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000766
Target Species:
Mouse, Human
Form:
Purified
Antigen: BIG2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 56 specifically detects BIG2 in human. It targets an epitope within amino acids 9-257 in the N-terminal region.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1 κ
Applications: Western Blot, Immunoprecipitation, Immunocytochemistry
Clone: 56
Formulation: __
Gene Symbols: ARFGEF2,ARFGEP2,BIG2
Immunogen: GST-tagged recombinant fragment corresponding to 249 amino acids from the N-terminal region of human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_006411
Target Species: Human
Form: Purified
Antigen:
BIG2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 56 specifically detects BIG2 in human. It targets an epitope within amino acids 9-257 in the N-terminal region.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1 κ
Applications:
Western Blot, Immunoprecipitation, Immunocytochemistry
Clone:
56
Formulation:
__
Gene Symbols:
ARFGEF2,ARFGEP2,BIG2
Immunogen:
GST-tagged recombinant fragment corresponding to 249 amino acids from the N-terminal region of human Brefeldin A-inhibited guanine nucleotide-exchange protein 2 (BIG2).
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_006411
Target Species:
Human
Form:
Purified