MABE1002MI
MilliporeSigma™ anti-DIS3-like Exonuclease 2 Clone: 9H2.1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABE1002MI-Each-of-1 | In Stock | ₹ 42,095.52 |
MABE1002MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 42,095.52
GST (18%): ₹ 7,577.194
Total Price: ₹ 49,672.714
Antigen
DIS3-like Exonuclease 2
Classification
Monoclonal
Conjugate
Unconjugated
Gene Accession No.
Q8IYB7
Host Species
Mouse
Purification Method
Protein G purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with isoforms 1-4. Reactivity toward isoform 5 has not been determined.
Content And Storage
2°C to 8°C for one year from date of shipment
Isotype
IgG1 κ
Applications
Western Blot
Clone
9H2.1
Formulation
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols
DIS3L2, FAM6A
Immunogen
GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human DIS3-like Exonuclease 2.
Quantity
100 μg
Research Discipline
Epigenetics, Nuclear Function
Gene ID (Entrez)
NP_689596
Target Species
Human
Form
Purified
Related Products
Description
- Specifically detects DIS3-like Exonuclease 2 Clone: 9H2.1 in Human samples, and it is validated for Western Blotting DIS3-like exonuclease 2 (UniProt Q8IYB7; also known as DIS3 mitotic control homolog-like 2, DIS3L2, Family with sequence similarity 6 member A, hDIS3L2) is encoded by the DIS3L2 (also known as FAM6A, PRLMNS) gene (Gene ID 129563) in human
- Cytoplasmic mRNAs are regulated by degradations to ensure a fast and efficient control of the transcriptome at the post-transcriptional level
- The degradation process is initiated by deadenylation, followed by decapping, after which mRNA is accessible to digestion by the Xrn1 exonuclease in the 5'-3' direction or by the exosome complex in the 3'-5' direction
- In yeast, the cytoplasmic exosome consists of nine inactive subunits (core ring structure) plus an active ribonuclease Rrp44/Dis3
- Three Dis3 isoforms exist in human, DIS3, DIS3L, and DIS3L2
- DIS3 is nuclear, and DIS3L and DIS3L2 are cytoplasmic
- In addtion to mRNAs, DIS3L2 is also reported to mediate the degradtion of 3' uridylated let-7 precursor (pre-let-7) miRNA
- Lin28 is a pluripotency factor expressed in stem cells and cancer cells, where it helps maintain the cells in an undifferentiated and proliferative state by preventing miRNA let-7 maturation
- Lin28 binds to pre-let-7 and recruits 3' terminal uridylyl transferase, which in turn marks pre-let-7 via 3' oligouridylation for degradation by DIS3L2
- Cellular DIS3L2 depletion causes mitotic abnormalities due to the deregulation of the expression of mitotic control proteins and DIS3L2 gene mutations are linked to the congenital overgrowth disease Perlman syndrome.
Compare Similar Items
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Antigen: DIS3-like Exonuclease 2
Classification: Monoclonal
Conjugate: Unconjugated
Gene Accession No.: Q8IYB7
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with isoforms 1-4. Reactivity toward isoform 5 has not been determined.
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Applications: Western Blot
Clone: 9H2.1
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: DIS3L2, FAM6A
Immunogen: GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human DIS3-like Exonuclease 2.
Quantity: 100 μg
Research Discipline: Epigenetics, Nuclear Function
Gene ID (Entrez): NP_689596
Target Species: Human
Form: Purified
Antigen:
DIS3-like Exonuclease 2
Classification:
Monoclonal
Conjugate:
Unconjugated
Gene Accession No.:
Q8IYB7
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with isoforms 1-4. Reactivity toward isoform 5 has not been determined.
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ
Applications:
Western Blot
Clone:
9H2.1
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
DIS3L2, FAM6A
Immunogen:
GST-tagged recombinant protein corresponding to the Internal (N-terminal half) of human DIS3-like Exonuclease 2.
Quantity:
100 μg
Research Discipline:
Epigenetics, Nuclear Function
Gene ID (Entrez):
NP_689596
Target Species:
Human
Form:
Purified
Antigen: N6-methyladenosine (m6A)
Classification: Monoclonal
Conjugate: __
Gene Accession No.: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 λ
Applications: Dot Blot, Immunoprecipitation
Clone: 17-3-4-1
Formulation: Purified mouse monoclonal IgG1λ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: __
Immunogen: Hapten N6-methyladenosine-5'-mono-phosphate conjugated to BSA of all N6-methyladenosine (m6A).
Quantity: 100 μg
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: All species
Form: Purified
Antigen:
N6-methyladenosine (m6A)
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 λ
Applications:
Dot Blot, Immunoprecipitation
Clone:
17-3-4-1
Formulation:
Purified mouse monoclonal IgG1λ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
__
Immunogen:
Hapten N6-methyladenosine-5'-mono-phosphate conjugated to BSA of all N6-methyladenosine (m6A).
Quantity:
100 μg
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
All species
Form:
Purified
Antigen: TEL-AML1 fusion
Classification: Monoclonal
Conjugate: __
Gene Accession No.: P41212; Q01196
Host Species: Rat
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Applications: ChIP Assay, Flow Cytometry, Western Blot
Clone: 6F2
Formulation: Purified rat monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols: ETV6; TEL; TEL1; RUNX1; AML1; CBFA2
Immunogen: KLH-conjugated linear peptide corresponding to human TEL-AML1 fusion.
Quantity: 50 μL
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): NP_001978; NP_001116079
Target Species: Human
Form: Purified
Antigen:
TEL-AML1 fusion
Classification:
Monoclonal
Conjugate:
__
Gene Accession No.:
P41212; Q01196
Host Species:
Rat
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ
Applications:
ChIP Assay, Flow Cytometry, Western Blot
Clone:
6F2
Formulation:
Purified rat monoclonal IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Symbols:
ETV6; TEL; TEL1; RUNX1; AML1; CBFA2
Immunogen:
KLH-conjugated linear peptide corresponding to human TEL-AML1 fusion.
Quantity:
50 μL
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
NP_001978; NP_001116079
Target Species:
Human
Form:
Purified
Antigen: pan-ADP-ribose binding reagent
Classification: Polyclonal
Conjugate: __
Gene Accession No.: __
Host Species: E. coli
Purification Method: Ni-NTA agarose
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -80°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype: __
Applications: Dot Blot
Clone: __
Formulation: Purified fromE. coliby Ni-NTA agarose. Supplied in buffer containing 10mM Tris pH 7.5, 0.2M NaCl, 10% Glycerol, 10mM Imidazole, 1mM PMSF, 1mM β-Mercaptoethanol, 10% glycerol without preservatives.
Gene Symbols: __
Immunogen: __
Quantity: 200 μL
Research Discipline: Epigenetics and Nuclear Function
Gene ID (Entrez): __
Target Species: Human, Mouse
Form: Purified
Antigen:
pan-ADP-ribose binding reagent
Classification:
Polyclonal
Conjugate:
__
Gene Accession No.:
__
Host Species:
E. coli
Purification Method:
Ni-NTA agarose
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -80°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -80°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Isotype:
__
Applications:
Dot Blot
Clone:
__
Formulation:
Purified fromE. coliby Ni-NTA agarose. Supplied in buffer containing 10mM Tris pH 7.5, 0.2M NaCl, 10% Glycerol, 10mM Imidazole, 1mM PMSF, 1mM β-Mercaptoethanol, 10% glycerol without preservatives.
Gene Symbols:
__
Immunogen:
__
Quantity:
200 μL
Research Discipline:
Epigenetics and Nuclear Function
Gene ID (Entrez):
__
Target Species:
Human, Mouse
Form:
Purified