MABS1298MI
MilliporeSigma™ PAR4, Mouse, Unlabeled, Clone: 5F10,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1298MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABS1298MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
PAR4
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2bλ antibody in PBS without preservatives.
Gene Accession No.
Q96RI0
Immunogen
MBP-conjugated recombinant human PAR4 N-terminal fragment including the propeptide sequence.
Quantity
100 μL
Research Discipline
Signaling
Gene ID (Entrez)
NP_003941
Target Species
Human
Form
Purified
Applications
Immunocytochemistry, Inhibition Assays, Western Blot
Clone
5F10
Conjugate
Unconjugated
Gene
F2RL3, PAR4
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 5F10 recognizes a propeptide epitope near (N-terminal to) the thrombin-cleavage site and protects cell surface PAR4 against thrombin cleavage (Mumaw, M.M., et al. (2015). Thromb. Res. 135(6):1165-1171). Clone 5F10 recognizes prepro- and pro-, but not proteolytically activated, forms of human PAR4.
Content And Storage
Stable for 1 year at -20°C from date of receipt.
Isotype
IgG2b λ
Related Products
Description
- Proteinase-activated receptor 4 (UniProt Q96RI0; also known as Coagulation factor II receptor-like 3, PAR-4, Thrombin receptor-like 3) is encoded by the F2RL3 (also known as PAR4) gene (Gene ID 9002) in human
- Protease-activated receptors (PARs) constitute a unique family of seven-transmembrane, G-protein-coupled receptors (GPCRs) activated by proteolytic cleavage of their N-terminal propeptide sequence
- Once cleaved off, the N-terminal propeptide fragment functions as a ligand and activates the receptor by binding the second extracellular loop
- The four PAR family members (PAR-1 to PAR-4) are widely expressed and activated by multiple proteases, and utilize different types of G-proteins (Gi, Gq, and G12/13) for signal transdution depending on the activating protease and cellular context
- PAR-4 is expressed on platelets and exhibits a low-affinity for thrombin
- However, PAR-4 is able to form hetero-oligomers with both PAR-1 and the ADP receptor P2Y12 to mediate thrombin- and ADP-initiated signaling
- PAR-4 cleavage is significantly enhanced through hetero-oligomerization with PAR-1, and PAR-4 interaction with P2Y12 is directly linked to arrestin-2 recruitment and AKT signaling
- PAR-4 is a 7-transmembrane (a.a
- 83-103, 109-129, 152-172, 192-213, 248-268, 284-304, 320-343) GPCR activated by thrombin cleavage between R47 and G48, having 3 extracellular loops and 3 intracellular loops between the extracellular N-terminal end (a.a
- 48-82) the cytoplasmic C-terminal tail (a.a
- 344-385).
Compare Similar Items
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Antigen: PAR4
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG2bλ antibody in PBS without preservatives.
Gene Accession No.: Q96RI0
Immunogen: MBP-conjugated recombinant human PAR4 N-terminal fragment including the propeptide sequence.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_003941
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Inhibition Assays, Western Blot
Clone: 5F10
Conjugate: Unconjugated
Gene: F2RL3, PAR4
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 5F10 recognizes a propeptide epitope near (N-terminal to) the thrombin-cleavage site and protects cell surface PAR4 against thrombin cleavage (Mumaw, M.M., et al. (2015). Thromb. Res. 135(6):1165-1171). Clone 5F10 recognizes prepro- and pro-, but not proteolytically activated, forms of human PAR4.
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Isotype: IgG2b λ
Antigen:
PAR4
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG2bλ antibody in PBS without preservatives.
Gene Accession No.:
Q96RI0
Immunogen:
MBP-conjugated recombinant human PAR4 N-terminal fragment including the propeptide sequence.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_003941
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Inhibition Assays, Western Blot
Clone:
5F10
Conjugate:
Unconjugated
Gene:
F2RL3, PAR4
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 5F10 recognizes a propeptide epitope near (N-terminal to) the thrombin-cleavage site and protects cell surface PAR4 against thrombin cleavage (Mumaw, M.M., et al. (2015). Thromb. Res. 135(6):1165-1171). Clone 5F10 recognizes prepro- and pro-, but not proteolytically activated, forms of human PAR4.
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Isotype:
IgG2b λ
Antigen: ATP Synthase subunit β
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P06576
Immunogen: His-tagged recombinant protein corresponding to human ATP Synthase subunit β.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001677
Target Species: Human, Mouse, Rat
Form: Purified
Applications: Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone: 11/21-7-A8
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Antigen:
ATP Synthase subunit β
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P06576
Immunogen:
His-tagged recombinant protein corresponding to human ATP Synthase subunit β.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001677
Target Species:
Human, Mouse, Rat
Form:
Purified
Applications:
Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone:
11/21-7-A8
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ
Antigen: Apolipoprotein A-I
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged full-length human recombinant Apolipoprotein A-I
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_000030
Target Species: Human
Form: Purified
Applications: Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone: Wt20-7
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone Wt20-7 specifically detects human Apolipoprotein A-I.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Antigen:
Apolipoprotein A-I
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged full-length human recombinant Apolipoprotein A-I
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000030
Target Species:
Human
Form:
Purified
Applications:
Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone:
Wt20-7
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone Wt20-7 specifically detects human Apolipoprotein A-I.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1
Antigen: Apolipoprotein A-I
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: GST-tagged full-length human recombinant Apolipoprotein A-I
Quantity: 25 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_000030
Target Species: Human
Form: Purified
Applications: Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone: Wt20-7
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone Wt20-7 specifically detects human Apolipoprotein A-I.
Content And Storage: Stable for 1 year at 2-8°C from date of receipt.
Isotype: IgG1
Antigen:
Apolipoprotein A-I
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal antibody IgG1 in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
GST-tagged full-length human recombinant Apolipoprotein A-I
Quantity:
25 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_000030
Target Species:
Human
Form:
Purified
Applications:
Dot Blot, ELISA, Immunocytochemistry, Western Blot
Clone:
Wt20-7
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone Wt20-7 specifically detects human Apolipoprotein A-I.
Content And Storage:
Stable for 1 year at 2-8°C from date of receipt.
Isotype:
IgG1