7161643
Tocris Bioscience™ KYP 2047
High affinity prolyl oligopeptidase inhibitor (Ki = 0.023 nM); anti-angiogenic, neuroprotective and brain penetrant
Manufacturer: Fischer Scientific
CAS Number: 796874-99-2
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Chemical Name or Material
(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
Molecular Formula
C20H25N3O2
Purity
98%
CAS
796874-99-2
Formula Weight
339.44
Other Options
| Image | Product Name | Manufacturer | Price Range | |
|---|---|---|---|---|
 | Tocris Bioscience™ KYP 2047 | Fischer Scientific | ₹ 63,870.54 | |
| | Tocris Bioscience™ KYP 2047 | Fischer Scientific | ₹ 16,444.63 | |
 | Sigma Aldrich Fine Chemicals Biosciences KYP-2047 >=95% (HPLC) | 796874-99-2 | MFCD22201003 | 25MG | Sigma Aldrich Fine Chemicals Biosciences | ₹ 74,710.99 | |
 | 796874-99-2 | KYP-2047；796874-99-2 | A2B Chem | ₹ 4,620.24 - ₹ 45,432.36 |
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Description
- KYP 2047 is a high affinity prolyl oligopeptidase (POP) inhibitor (Ki = 0.023 nM)
- Clears α-synuclein aggregates induced by oxidative stress in neuronal cells
- Inhibits the formation of AcSDKP from its precursor 43-mer thymosin β4 (Tβ4)
- Induces angiogenesis via POP inhibition
- It reduces tau aggregation in tau-transfected HEK-293 cells and N2A cells as well as in human iPSC-derived neurons from patients with frontotemporal dementia
- In vivo , treatment with KYP 2047 of transgenic mice with tauopathy, reduces tau aggregation in the brain and cerebrospinal fluid and slows cognitive decline
- Anti-angiogenic and neuroprotective
- Brain penetrant.
SAFETY INFORMATION
- Recommended Storage : Store at -20°C
Compare Similar Items
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Chemical Name or Material: (2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
Molecular Formula: C20H25N3O2
Purity: 98%
CAS: 796874-99-2
Formula Weight: 339.44
Chemical Name or Material:
(2S)-1-[[(2S)-1-(1-Oxo-4-phenylbutyl)-2-pyrrolidinyl]carbonyl]-2-pyrrolidinecarbonitrile
Molecular Formula:
C20H25N3O2
Purity:
98%
CAS:
796874-99-2
Formula Weight:
339.44
Chemical Name or Material: N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Molecular Formula: C26H30ClN3O4S
Purity: 98%
CAS: 1808951-93-0
Formula Weight: 516.05
Chemical Name or Material:
N-[(2R,3S)-2-(4-Chlorophenyl)-1-(1,2-dihydro-1,4-dimethyl-2-oxo-7-quinolinyl)-6-oxo-3-piperidinyl]-2-methyl-1-propanesulfonamide
Molecular Formula:
C26H30ClN3O4S
Purity:
98%
CAS:
1808951-93-0
Formula Weight:
516.05
Chemical Name or Material: N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
Molecular Formula: C18H22BrN5O3
Purity: 98%
CAS: 911222-45-2
Formula Weight: 436.3
Chemical Name or Material:
N-[5-Bromo-4-methyl-2-[(2S)-2-morpholinylmethoxy)phenyl]-N'-(5-methyl-2-pyrazinyl)urea
Molecular Formula:
C18H22BrN5O3
Purity:
98%
CAS:
911222-45-2
Formula Weight:
436.3
Chemical Name or Material: N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
Molecular Formula: C14H14N2O.2HCl
Purity: 98%
CAS: 64821-19-8
Formula Weight: 299.2
Chemical Name or Material:
N-(8-Hydroxy-5-quinolylmethyl)-N-methyl-2-propynylamine dihydrochloride
Molecular Formula:
C14H14N2O.2HCl
Purity:
98%
CAS:
64821-19-8
Formula Weight:
299.2