ABN1016MI
MilliporeSigma™ CCM3/PDCD10, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABN1016MI-Each-of-1 | In Stock | ₹ 38,734.72 |
ABN1016MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
CCM3/PDCD10
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDCD10, CCM3, TFAR15
Host Species
Rabbit
Purification Method
Affinity Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
This polyclonal antibody detected the expected ∽25 kDa target band in lysate from untreated, but not CCM3 shRNA-treated, EA.hy926 human umbilical vein endothelial cells (Courtesy of Kyle M. Draheim, Ph.D., Xiaofeng Li, Ph.D., Rong Zhang, David A.Calderwood, Ph.D. and Titus J. Boggon, Ph.D., Yale University, U.S.A.).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q9BUL8
Immunogen
Recombinant full-length human CCM3/PDCD10.
Quantity
100 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_009148
Target Species
Human
Related Products
Description
- Programmed cell death protein 10 (UniProt Q9BUL8; also known as Cerebral cavernous malformations 3 protein, TF-1 cell apoptosis-related protein 15) is encoded by the PDCD10 (also known as CCM3, TFAR15) gene (Gene ID 11235) in human
- PDCD10/CCM3 is an ubiquitously expressed adaptor protein that plays a role in vascularization and vessel permeability, as well as in regulating cell survival and death
- Both the N-terminal dimerization domain and the C-terminal focal adhesion targeting-homology (FAT-H) domain mediate its interaction with a diverse array of signaling partners
- The FAT-H domain mediates PDCD10 interaction with CCM2 to form the KRIT1 CCM2 PDCD10 complex, as well as with striatin to form the striatin interacting phosphatase and kinase (STRIPAK) complex, while the dimerization domain mediates interactions with GCKIII serine/threonine kinases (MST4/MASK, STK24/MST3 and STK25)
- PDCD10 overexpression leads to increased cell migration, an essential process for blood vessel formation
- Loss of either PDCD10 or STK24 increases neutrophil exocytosis as a result of disrupted interaction with UNC13D, a regulator of vesicle fusion
- Loss-of-function mutations in CCM1/KRIT1, CCM2/OSM, or CCM3/PDCD10 gene cause cerebral cavernous malformations (CCMs).
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Antigen: CCM3/PDCD10
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PDCD10, CCM3, TFAR15
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This polyclonal antibody detected the expected ∽25 kDa target band in lysate from untreated, but not CCM3 shRNA-treated, EA.hy926 human umbilical vein endothelial cells (Courtesy of Kyle M. Draheim, Ph.D., Xiaofeng Li, Ph.D., Rong Zhang, David A.Calderwood, Ph.D. and Titus J. Boggon, Ph.D., Yale University, U.S.A.).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q9BUL8
Immunogen: Recombinant full-length human CCM3/PDCD10.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_009148
Target Species: Human
Antigen:
CCM3/PDCD10
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PDCD10, CCM3, TFAR15
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This polyclonal antibody detected the expected ∽25 kDa target band in lysate from untreated, but not CCM3 shRNA-treated, EA.hy926 human umbilical vein endothelial cells (Courtesy of Kyle M. Draheim, Ph.D., Xiaofeng Li, Ph.D., Rong Zhang, David A.Calderwood, Ph.D. and Titus J. Boggon, Ph.D., Yale University, U.S.A.).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4) 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q9BUL8
Immunogen:
Recombinant full-length human CCM3/PDCD10.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_009148
Target Species:
Human
Antigen: LRP1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: LRP1, A2MR, APR
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Recognizes the Pro- and mature LRP-1 (a.a. 1-4544 and 20-4544, respectively), the beta-secretase-cleaved, membrane-bound LRP-85, and the gamma-secretase-cleaved intracellular domain LRPICD fragment, but not the beta-secretase-cleaved extracellular LRP-515 fragment.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: Q07954
Immunogen: GST-tagged recombinant human LRP1 intracellular domain (LRPICD).
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_002323
Target Species: Mouse
Antigen:
LRP1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
LRP1, A2MR, APR
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Recognizes the Pro- and mature LRP-1 (a.a. 1-4544 and 20-4544, respectively), the beta-secretase-cleaved, membrane-bound LRP-85, and the gamma-secretase-cleaved intracellular domain LRPICD fragment, but not the beta-secretase-cleaved extracellular LRP-515 fragment.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
Q07954
Immunogen:
GST-tagged recombinant human LRP1 intracellular domain (LRPICD).
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_002323
Target Species:
Mouse
Antigen: Sacsin
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration: __
Formulation: Purified rabbit polyclonal antibody in PBS with 0.05% sodium azide and 50% glycerol.
Gene Accession No.: Q9NZJ4
Immunogen: KLH-conjugated recombinant protein corresponding to the C-terminus of human Sacsin.
Quantity: 200 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_055178
Target Species: Human, Monkey, Mouse, Rat
Antigen:
Sacsin
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance. Note: Variability in freezer temperatures below -20°C may cause glycerol containing solutions to become frozen during storage.
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Concentration:
__
Formulation:
Purified rabbit polyclonal antibody in PBS with 0.05% sodium azide and 50% glycerol.
Gene Accession No.:
Q9NZJ4
Immunogen:
KLH-conjugated recombinant protein corresponding to the C-terminus of human Sacsin.
Quantity:
200 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_055178
Target Species:
Human, Monkey, Mouse, Rat
Antigen: GAD65
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Affinity Purified
Regulatory Status: __
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2-8°C for 12 months
Applications: Western Blot
Concentration: __
Formulation: Purified Rabbit Polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: KLH-conjugated linear peptide corresponding to human GAD65.
Quantity: 100 μg
Research Discipline: __
Gene ID (Entrez): NP_000809
Target Species: Canine, Human, Mouse, Porcine, Rat
Antigen:
GAD65
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Affinity Purified
Regulatory Status:
__
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2-8°C for 12 months
Applications:
Western Blot
Concentration:
__
Formulation:
Purified Rabbit Polyclonal in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
KLH-conjugated linear peptide corresponding to human GAD65.
Quantity:
100 μg
Research Discipline:
__
Gene ID (Entrez):
NP_000809
Target Species:
Canine, Human, Mouse, Porcine, Rat