ABS1638MI
MilliporeSigma™ PDZK1, Rabbit, Unlabeled, Polyclonal,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | ABS1638MI-Each-of-1 | In Stock | ₹ 41,307.51 |
ABS1638MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 41,307.51
GST (18%): ₹ 7,435.352
Total Price: ₹ 48,742.862
Antigen
PDZK1
Classification
Polyclonal
Conjugate
Unconjugated
Gene
PDZK1, CAP70, CLAMP, NHERF3, PDZD1
Host Species
Rabbit
Purification Method
Protein A Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Expected to react with both spliced isoforms of human PDZK1 reported by UniProt (Q5T2W1).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Applications
Western Blot
Concentration
Please refer to lot specific datasheet.
Formulation
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q5T2W1
Immunogen
Full-length recombinant human PDZK1.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_001188254
Target Species
Human
Form
Purified
Related Products
Description
- Na(+)/H(+) exchange regulatory cofactor NHE-RF3 (UniProt Q5T2W1; also known as CFTR-associated protein of 70 kDa, Na/Pi cotransporter C-terminal-associated protein 1, Na(+)/H(+) exchanger regulatory factor 3, NaPi-Cap1, NHERF-3, PDZ domain-containing protein 1, Sodium-hydrogen exchanger regulatory factor 3) is encoded by the PDZK1 (also known as CAP70, CLAMP, NHERF3, PDZD1) gene (Gene ID 5174) in human
- PDZK1/NHERF-3 is an adaptor protein that regulates several membrane-transporting proteins, including cystic fibrosis transmembrane conductance regulator (CFTR), multidrug resistance protein 4 (MRP4), parathyroid 1 receptor, somatostatin receptors 1-5 (SSTRs), human prostacyclin receptor (hIPR), 2-adrenergic receptor ( 2AR), mGluR 5, purinergic receptor P2Y1, CCR5, opioid receptor, corticotropin-releasing factor receptor 1 (CRFR1) and serotonin 2A receptor (5-HT2AR)
- PDZK1/NHERF3 is predominantly expressed in epithelial and endothelial cells in the liver, kidney and small intestine, while lower level is also found at neuronal synapses
- PDZK1 overexpression selectively enhances CRFR1-stimulated ERK1/2 phosphorylation without affecting CRFR1 endocytosis, while PDZK1 negatively regulates 5-HT2AR endocytosis without affecting 5-HT2AR-mediated ERK1/2 phosphorylation
- Nherf3 gene knockout in mice results in profound reductions in Mrp4 expression and Mrp4-mediated drug transport in the kidney
- Nherf3-/- mice are also more prone to CFTR-mediated secretory diarrhea
- Human PDZK1 is a 519-amino acid protein with four PDZ (PSD-95/discs large/ZO-1) motifs (a.a
- 9-90, 134-215, 243-323, 378-458)
- Alternative splicing produces a 408-a.a
- isoform missing a.a
- 154-264.
Compare Similar Items
Show Difference
Antigen: PDZK1
Classification: Polyclonal
Conjugate: Unconjugated
Gene: PDZK1, CAP70, CLAMP, NHERF3, PDZD1
Host Species: Rabbit
Purification Method: Protein A Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Expected to react with both spliced isoforms of human PDZK1 reported by UniProt (Q5T2W1).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q5T2W1
Immunogen: Full-length recombinant human PDZK1.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001188254
Target Species: Human
Form: Purified
Antigen:
PDZK1
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
PDZK1, CAP70, CLAMP, NHERF3, PDZD1
Host Species:
Rabbit
Purification Method:
Protein A Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Expected to react with both spliced isoforms of human PDZK1 reported by UniProt (Q5T2W1).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified rabbit polyclonal antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q5T2W1
Immunogen:
Full-length recombinant human PDZK1.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001188254
Target Species:
Human
Form:
Purified
Antigen: SPTLC2
Classification: Polyclonal
Conjugate: Unconjugated
Gene: SPTLC2, HSAN1C, KIAA0526, NSAN1C, LCB2
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Target-specificity of this antiserum was verified by negative blotting using pre-immune serum and by target band blocking using immunogen peptides (Hornemann, T., et al. (2006). J. Biol. Chem. 281(49):37275-37281).
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.: O15270
Immunogen: A mixture of two linear peptides corresponding to sequences from the N-terminal region and the C-terminal end of human SPTLC2.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_004854
Target Species: Human
Form: Serum
Antigen:
SPTLC2
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
SPTLC2, HSAN1C, KIAA0526, NSAN1C, LCB2
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Target-specificity of this antiserum was verified by negative blotting using pre-immune serum and by target band blocking using immunogen peptides (Hornemann, T., et al. (2006). J. Biol. Chem. 281(49):37275-37281).
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antibody serum with 0.05% Sodium Azide.
Gene Accession No.:
O15270
Immunogen:
A mixture of two linear peptides corresponding to sequences from the N-terminal region and the C-terminal end of human SPTLC2.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_004854
Target Species:
Human
Form:
Serum
Antigen: SPTLC1
Classification: Polyclonal
Conjugate: __
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications: Western Blot
Concentration: __
Formulation: Rabbit polyclonal antibody serum with 0.05% sodium azide.
Gene Accession No.: O15269
Immunogen: Two linear peptides corresponding to sequences from the N- and a C-terminal regions of human SPTLC1 cytoplasmic domain.
Quantity: 100 μL
Research Discipline: Signaling
Gene ID (Entrez): NP_006406
Target Species: Human
Form: Serum
Antigen:
SPTLC1
Classification:
Polyclonal
Conjugate:
__
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles which may damage IgG and affect product performance.
Applications:
Western Blot
Concentration:
__
Formulation:
Rabbit polyclonal antibody serum with 0.05% sodium azide.
Gene Accession No.:
O15269
Immunogen:
Two linear peptides corresponding to sequences from the N- and a C-terminal regions of human SPTLC1 cytoplasmic domain.
Quantity:
100 μL
Research Discipline:
Signaling
Gene ID (Entrez):
NP_006406
Target Species:
Human
Form:
Serum
Antigen: DsbA-L
Classification: Polyclonal
Conjugate: Unconjugated
Gene: __
Host Species: Rabbit
Purification Method: Unpurified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: This rabbit polyclonal antibody detects DsbA-L (Glutathione S-transferase kappa 1) in human and mouse cells.
Content And Storage: Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications: Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration: Please refer to lot specific datasheet.
Formulation: Rabbit polyclonal antiserum with 0.05% sodium azide with 20% glycerol.
Gene Accession No.: __
Immunogen: Myc-tagged full length recombinant protein from mouse.
Quantity: 25 μL
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human, Mouse
Form: __
Antigen:
DsbA-L
Classification:
Polyclonal
Conjugate:
Unconjugated
Gene:
__
Host Species:
Rabbit
Purification Method:
Unpurified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
This rabbit polyclonal antibody detects DsbA-L (Glutathione S-transferase kappa 1) in human and mouse cells.
Content And Storage:
Stable for 1 year at -20°C from date of receipt. Handling Recommendations: Upon receipt and prior to removing the cap, centrifuge the vial and gently mix the solution. Aliquot into microcentrifuge tubes and store at -20°C. Avoid repeated freeze/thaw cycles, which may damage IgG and affect product performance.
Applications:
Immunocytochemistry, Immunoprecipitation, Western Blot
Concentration:
Please refer to lot specific datasheet.
Formulation:
Rabbit polyclonal antiserum with 0.05% sodium azide with 20% glycerol.
Gene Accession No.:
__
Immunogen:
Myc-tagged full length recombinant protein from mouse.
Quantity:
25 μL
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human, Mouse
Form:
__