MABN1843
MilliporeSigma™ SET (I2PP2A), NT, Mouse, Unlabeled, Clone: 10E7,
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1843-Each-of-1 | In Stock | ₹ 34,965.81 |
MABN1843 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 34,965.81
GST (18%): ₹ 6,293.846
Total Price: ₹ 41,259.656
Antigen
SET (I2PP2A), NT
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
Q01105
Immunogen
Recombinant human SET (I2PP2A).
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001116293
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
10E7
Conjugate
Unconjugated
Gene
SET
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 10E7 detected both full-length human SET (I2PP2A) and the N-terminal fragment I2NTF generated by Asn endopeptidase (AEP) cleavage (Basurto-Islas, G., et al. (2013). J. Biol. Chem. 288(24):17495-17507).
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Protein SET (UniProt Q01105; also known as HLA-DR-associated protein II, IGAAD, Inhibitor of granzyme A-activated DNase, PHAPII, I-2PP2A, Phosphatase 2A inhibitor I2PP2A, TAF-I, Template-activating factor I) is encoded by the SET gene (Gene ID 6418) in human
- Protein SET (patient SE translocation ) adopted its name when it was originally identified in a leukemia study in 1992
- SET interacts with signaling pathways that promote normal cell growth and proliferation, as well as tumorigenesis and metastasis
- SET protein inhibits PP2A by enhancing lyase activity of P450c17, a substrate for PP2A when it is Ser- and Thr-phosphorylated
- Alternative splicings result in multiple SET isoforms, including SET-alpha (TAF-I alpha), SET-beta (TAF-I beta), where the N-terminal 37-amino acid sequence in Set-alpha is replaced with a different sequence of a shorter length in Set-beta
- In addition, there exists a shorter spliced Set- isoform without the nuclear localization signal (NLS)
- Both Set-alpha and Set-beta are predominantly localized in the nucleus, but differ in their expression levels among various cell and tissue types
- Set-beta is predominant in the brain relative to Set-alpha, whereas the opposite pattern was observed in tissues such as the spleen
- Set-beta functions have been described both in the nucleus and cytoplasm
- The presence of a nuclear localization signal (NLS) and phosphorylation govern Set- isoforms cellular localization
- Proteolytic cleavage of Set-beta at Lys176 by granzyme A or at Asn-175 by asparagine endopeptidase (AEP) results in the release of GzmA-activated DNase (GAAD) from a multiprotein complex
- Uninhibited in the absence of the full-length Set-eta, GAAD causes cell death by its DNA-nicking activity.
Compare Similar Items
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Antigen: SET (I2PP2A), NT
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q01105
Immunogen: Recombinant human SET (I2PP2A).
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001116293
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 10E7
Conjugate: Unconjugated
Gene: SET
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 10E7 detected both full-length human SET (I2PP2A) and the N-terminal fragment I2NTF generated by Asn endopeptidase (AEP) cleavage (Basurto-Islas, G., et al. (2013). J. Biol. Chem. 288(24):17495-17507).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
SET (I2PP2A), NT
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG2a in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q01105
Immunogen:
Recombinant human SET (I2PP2A).
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001116293
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
10E7
Conjugate:
Unconjugated
Gene:
SET
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 10E7 detected both full-length human SET (I2PP2A) and the N-terminal fragment I2NTF generated by Asn endopeptidase (AEP) cleavage (Basurto-Islas, G., et al. (2013). J. Biol. Chem. 288(24):17495-17507).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2a κ
Antigen: Synapsin-1
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: O88935
Immunogen: Recombinant full-length mouse synapsin-1.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_038708.3
Target Species: Mouse
Form: Purified
Applications: Immunocytochemistry, Western Blot
Clone: MEGS3-10A
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Purified by ion-exchange chromatography
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG2b κ
Antigen:
Synapsin-1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
O88935
Immunogen:
Recombinant full-length mouse synapsin-1.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_038708.3
Target Species:
Mouse
Form:
Purified
Applications:
Immunocytochemistry, Western Blot
Clone:
MEGS3-10A
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Purified by ion-exchange chromatography
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG2b κ
Antigen: DYRK1A
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: Q63470
Immunogen: His-tagged recombinant rat DYRK1A N-terminal fragment.
Quantity: 100 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_036923
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: 8D9
Conjugate: Unconjugated
Gene: Dyrk1a, Dyrk
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: The specificity of target band detection was confirmed by antibody blocking with an excess amount of DYRK1A prior to Western blotting (Murakami, N., et al. (2009). Biochemistry. 48(39):9297-9305).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
DYRK1A
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
Q63470
Immunogen:
His-tagged recombinant rat DYRK1A N-terminal fragment.
Quantity:
100 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_036923
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
8D9
Conjugate:
Unconjugated
Gene:
Dyrk1a, Dyrk
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
The specificity of target band detection was confirmed by antibody blocking with an excess amount of DYRK1A prior to Western blotting (Murakami, N., et al. (2009). Biochemistry. 48(39):9297-9305).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Neuregulin-2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P56974
Immunogen: Recombinant mouse mature Neuregulin-2.
Quantity: 200 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001161363
Target Species: Human
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
Clone: 8D11
Conjugate: Unconjugated
Gene: Nrg2
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 8D11 epitope lies within neuregulin-2, which corresponds to the extracellular domain of membrane-bound pro-neuregulin-2.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Neuregulin-2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P56974
Immunogen:
Recombinant mouse mature Neuregulin-2.
Quantity:
200 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001161363
Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin)
Clone:
8D11
Conjugate:
Unconjugated
Gene:
Nrg2
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 8D11 epitope lies within neuregulin-2, which corresponds to the extracellular domain of membrane-bound pro-neuregulin-2.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ