MABN1853
MilliporeSigma™ Neuregulin-2, Mouse, Unlabeled, Clone: 8D11,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN1853-Each-of-1 | In Stock | ₹ 37,453.03 |
MABN1853 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 37,453.03
GST (18%): ₹ 6,741.545
Total Price: ₹ 44,194.575
Antigen
Neuregulin-2
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
P56974
Immunogen
Recombinant mouse mature Neuregulin-2.
Quantity
200 μL
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_001161363
Target Species
Human
Form
Purified
Applications
Immunofluorescence, Immunohistochemistry (Paraffin)
Clone
8D11
Conjugate
Unconjugated
Gene
Nrg2
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone 8D11 epitope lies within neuregulin-2, which corresponds to the extracellular domain of membrane-bound pro-neuregulin-2.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG1 κ
Related Products
Description
- Pro-neuregulin-2, membrane-bound isoform (UniProt P56974; also known as Pro-NRG2) is encoded by the Nrg2 gene (Gene ID 100042150) in murine species
- The ErbB4 receptor is widely expressed in GABAergic interneurons and reply on the engagement of neuregulins (NRGs) as ligands for signaling during neural processes in the adolescent and adult central nervous system (CNS)
- NRG1 transcript is generally lower than NRG2 in postnatal CNS and NRG2 is a major functional ErbB4 ligand in the postnatal brain
- NRGs are synthesized as single-pass transmembrane pro-forms that is posttranslationally converted to signalling ligands by extracellular sheddases
- The presence of an extracellular immunoglobulin (Ig)-like domain allows NRG1/2 ectodomain to accumulate near the site of cleavage through interactions with extracellular matrix heparan proteoglycans
- NMDARs are required to release the NRG2 ectodomain from the surface of interneuron cell bodies
- Stimulation of ErbB4 by the NRG2 ectodomain not only promotes the internalization of ion channels from the cell surface, but also the association of ErbB4 with GluN2B-containing NMDARs, resulting in a rapid downregulation of NMDARs on inhibitory interneurons, but not pyramidal neurons.
Compare Similar Items
Show Difference
Antigen: Neuregulin-2
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P56974
Immunogen: Recombinant mouse mature Neuregulin-2.
Quantity: 200 μL
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001161363
Target Species: Human
Form: Purified
Applications: Immunofluorescence, Immunohistochemistry (Paraffin)
Clone: 8D11
Conjugate: Unconjugated
Gene: Nrg2
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 8D11 epitope lies within neuregulin-2, which corresponds to the extracellular domain of membrane-bound pro-neuregulin-2.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Neuregulin-2
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P56974
Immunogen:
Recombinant mouse mature Neuregulin-2.
Quantity:
200 μL
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001161363
Target Species:
Human
Form:
Purified
Applications:
Immunofluorescence, Immunohistochemistry (Paraffin)
Clone:
8D11
Conjugate:
Unconjugated
Gene:
Nrg2
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 8D11 epitope lies within neuregulin-2, which corresponds to the extracellular domain of membrane-bound pro-neuregulin-2.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Kallikrein 8/KLK8
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ antibody in 0.1M sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
Gene Accession No.: O60259
Immunogen: Recombinant full-length human kallikrein 8.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_009127.1
Target Species: Human, Mouse
Form: Purified
Applications: Functional Assay, ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone: 19-10
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
Kallikrein 8/KLK8
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ antibody in 0.1M sodium bicarbonate buffer, pH 8.2 with 0.02% sodium azide.
Gene Accession No.:
O60259
Immunogen:
Recombinant full-length human kallikrein 8.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_009127.1
Target Species:
Human, Mouse
Form:
Purified
Applications:
Functional Assay, ELISA, Immunohistochemistry (Paraffin), Western Blot
Clone:
19-10
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: ANO6/TMEM16F
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: Recombinant fragment corresponding to the first 294 amino acids from the N-terminal, cytoplasmic domain of human Anoctamin-6 (ANO6).
Quantity: 100 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: N429/19
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
ANO6/TMEM16F
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
Recombinant fragment corresponding to the first 294 amino acids from the N-terminal, cytoplasmic domain of human Anoctamin-6 (ANO6).
Quantity:
100 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
N429/19
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: ANO6/TMEM16F
Classification: Monoclonal
Concentration: 0.5 mg/mL
Formulation: Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.: __
Immunogen: Recombinant fragment corresponding to the first 294 amino acids from the N-terminal, cytoplasmic domain of human Anoctamin-6 (ANO6).
Quantity: 25 μL
Research Discipline: __
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin)
Clone: N429/19
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
ANO6/TMEM16F
Classification:
Monoclonal
Concentration:
0.5 mg/mL
Formulation:
Purified mouse monoclonal antibody IgG2b in buffer containing 0.1 M Tris-Glycine (pH 7.4), 150 mM NaCl with 0.05% sodium azide.
Gene Accession No.:
__
Immunogen:
Recombinant fragment corresponding to the first 294 amino acids from the N-terminal, cytoplasmic domain of human Anoctamin-6 (ANO6).
Quantity:
25 μL
Research Discipline:
__
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin)
Clone:
N429/19
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for 1 year at +2°C to +8°C from date of receipt.
Isotype:
IgG2b κ