MABN819
MilliporeSigma™ Tau, oligomeric, Mouse, Unlabeled, Clone: TOMA-1,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABN819-Each-of-1 | In Stock | ₹ 40,486.99 |
MABN819 - Each of 1
In Stock
Quantity
1
Base Price: ₹ 40,486.99
GST (18%): ₹ 7,287.658
Total Price: ₹ 47,774.648
Antigen
Tau, oligomeric
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse IgG2aκ in buffer containing PBS without preservatives.
Gene Accession No.
P10636
Immunogen
Recombinant human Tau-441 (Tau-F, Tau-4, 2N4R isoform) oligomers (Lasagna-Reeves, C. A., et al. (2012). FASEB J. 26(5):1946-1959).
Quantity
100 μg
Research Discipline
Neuroscience
Gene ID (Entrez)
NP_058519.3
Target Species
Human
Form
Purified
Applications
ELISA, Immunofluorescence, Immunohistochemistry, Neutralization, Western Blot
Clone
TOMA-1
Conjugate
Unconjugated
Gene
MAPT, TAU, MTBT1, MAPTL
Host Species
Mouse
Purification Method
Protein A Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone TOMA-1 (a.k.a. clone H12C10) is among more than 13 hybridomas derived from mice immunized with in vitro generated recombinant Tau-441 (Tau-F, Tau-4, 2N4R isoform) oligomers. These TOMAs are reported to specifically detect oligomeric tau without any significant reactivity toward monomeric tau, tau fibrils, Aβ oligomers, Aβ fibrils, or α-synuclein oligomers (Castillo-Carranza, D.L., et al. (2014). J. Neurosci. 34(12):4260-4272).
Content And Storage
Stable for 1 year at -20°C from date of receipt.
Isotype
IgG2a κ
Related Products
Description
- Microtubule-associated protein tau (UniProt P10636; also known as Neurofibrillary tangle protein, Paired helical filament-tau, PHF-tau) is encoded by the MAPT (also known as TAU, MAPT1, MTBTL) gene (Gene ID 4137) in human
- In Alzheimer's disease (AD) pathology, accumulation of the microtubule-associated protein tau takes place primarily in the neurons
- Tau accumulates in both the somatodendritic and axonal domains of neurons
- Tau also accumulates in the soma as neurofibrillary tangles (NFTs)
- Cell death and synaptic lesions occur independently of NFT formation, and research indicates that NFT formation alone is insufficient for neurodegeneration, suggesting that soluble tau aggregates may be the more toxic and pathologically significant tau species
- Tau oligomers are neurotoxic when applied extracellularly to cultured neuronal cells, and tau oligomers (but not fibrils) induce neurodegeneration and synaptic and mitochondrial dysfunction in vivo
- Moreove, researchers are able to use tau oligomers as a reliable biomarker to differentiate AD brains from age-matched non-AD brains.
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Antigen: Tau, oligomeric
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG2aκ in buffer containing PBS without preservatives.
Gene Accession No.: P10636
Immunogen: Recombinant human Tau-441 (Tau-F, Tau-4, 2N4R isoform) oligomers (Lasagna-Reeves, C. A., et al. (2012). FASEB J. 26(5):1946-1959).
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_058519.3
Target Species: Human
Form: Purified
Applications: ELISA, Immunofluorescence, Immunohistochemistry, Neutralization, Western Blot
Clone: TOMA-1
Conjugate: Unconjugated
Gene: MAPT, TAU, MTBT1, MAPTL
Host Species: Mouse
Purification Method: Protein A Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone TOMA-1 (a.k.a. clone H12C10) is among more than 13 hybridomas derived from mice immunized with in vitro generated recombinant Tau-441 (Tau-F, Tau-4, 2N4R isoform) oligomers. These TOMAs are reported to specifically detect oligomeric tau without any significant reactivity toward monomeric tau, tau fibrils, Aβ oligomers, Aβ fibrils, or α-synuclein oligomers (Castillo-Carranza, D.L., et al. (2014). J. Neurosci. 34(12):4260-4272).
Content And Storage: Stable for 1 year at -20°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Tau, oligomeric
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG2aκ in buffer containing PBS without preservatives.
Gene Accession No.:
P10636
Immunogen:
Recombinant human Tau-441 (Tau-F, Tau-4, 2N4R isoform) oligomers (Lasagna-Reeves, C. A., et al. (2012). FASEB J. 26(5):1946-1959).
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_058519.3
Target Species:
Human
Form:
Purified
Applications:
ELISA, Immunofluorescence, Immunohistochemistry, Neutralization, Western Blot
Clone:
TOMA-1
Conjugate:
Unconjugated
Gene:
MAPT, TAU, MTBT1, MAPTL
Host Species:
Mouse
Purification Method:
Protein A Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone TOMA-1 (a.k.a. clone H12C10) is among more than 13 hybridomas derived from mice immunized with in vitro generated recombinant Tau-441 (Tau-F, Tau-4, 2N4R isoform) oligomers. These TOMAs are reported to specifically detect oligomeric tau without any significant reactivity toward monomeric tau, tau fibrils, Aβ oligomers, Aβ fibrils, or α-synuclein oligomers (Castillo-Carranza, D.L., et al. (2014). J. Neurosci. 34(12):4260-4272).
Content And Storage:
Stable for 1 year at -20°C from date of receipt.
Isotype:
IgG2a κ
Antigen: polyQ Disease Proteins
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: P42858
Immunogen: N-terminally GST-tagged human Huntingtin (Htt) fragment corresponding to exon 1-coded seqeunce containing a stretch of 66 glutamines (GST-171-Q66; Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): __
Target Species: Human
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry, Inhibition Assays, Western Blot
Clone: 3B5H10
Conjugate: Unconjugated
Gene: HTT, HD, IT15
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone 3B5H10 targeted epitope is exposed among some of the many conformations adopted by monomeric and possibly small oligomeric polyQ species of mutant Huntingtin protein (mHtt), but disappears in higher-molecular weight aggregated forms, such as inclusion bodies (IBs). The epitope also exists in mutant forms of other polyQ-containing proteins that cause neurodegeneration, including the androgen receptor, atrophin, and ataxin-3 (Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG1
Antigen:
polyQ Disease Proteins
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
P42858
Immunogen:
N-terminally GST-tagged human Huntingtin (Htt) fragment corresponding to exon 1-coded seqeunce containing a stretch of 66 glutamines (GST-171-Q66; Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
__
Target Species:
Human
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry, Inhibition Assays, Western Blot
Clone:
3B5H10
Conjugate:
Unconjugated
Gene:
HTT, HD, IT15
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone 3B5H10 targeted epitope is exposed among some of the many conformations adopted by monomeric and possibly small oligomeric polyQ species of mutant Huntingtin protein (mHtt), but disappears in higher-molecular weight aggregated forms, such as inclusion bodies (IBs). The epitope also exists in mutant forms of other polyQ-containing proteins that cause neurodegeneration, including the androgen receptor, atrophin, and ataxin-3 (Miller, J., et al. (2011). Nat. Chem. Biol. 7(12):925-934).
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG1
Antigen: LRRTM4
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q86VH4
Immunogen: Conjugated linear peptide corresponding to human LRRTM4.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_001128217
Target Species: Human, Mouse, Rat
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry, Western Blot
Clone: N205B/22
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG1 κ
Antigen:
LRRTM4
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q86VH4
Immunogen:
Conjugated linear peptide corresponding to human LRRTM4.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_001128217
Target Species:
Human, Mouse, Rat
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry, Western Blot
Clone:
N205B/22
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG1 κ
Antigen: Retinal Dehydrogenase 1/ALDH1A1
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1k antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P00352
Immunogen: GST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.
Quantity: 100 μg
Research Discipline: Neuroscience
Gene ID (Entrez): NP_000680
Target Species: Human
Form: Purified
Applications: Immunohistochemistry (Paraffin), Western Blot
Clone: 8D7.1
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Antigen:
Retinal Dehydrogenase 1/ALDH1A1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1k antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P00352
Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal of human Retinal Dehydrogenase 1/ALDH1A1.
Quantity:
100 μg
Research Discipline:
Neuroscience
Gene ID (Entrez):
NP_000680
Target Species:
Human
Form:
Purified
Applications:
Immunohistochemistry (Paraffin), Western Blot
Clone:
8D7.1
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ