PS101310T
MilliporeSigma™ anti-PhosphoDetect VEGFR2 (pTyr1054/1059), Polyclonal
Manufacturer: MilliporeSigma™
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| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | PS101310T-Each-of-1 | In Stock | ₹ 55,536.14 |
PS101310T - Each of 1
In Stock
Quantity
1
Base Price: ₹ 55,536.14
GST (18%): ₹ 9,996.505
Total Price: ₹ 65,532.645
Antigen
PhosphoDetect™ VEGFR2 (pTyr1054/1059)
Classification
Polyclonal
Formulation
In Dulbecco's PBS (without Mg2+and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.3 (± 0.1).
Immunogen
a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1054/1059phosphorylation sites of mouse and human VEGFR-2
Regulatory Status
RUO
Test Specificity
Recognizes the ∽200kDa VEGFR-2 protein phosphorylated at Tyr1054/1059in porcine pancreatic cells transfected with a CSF-1/mouse VEGFR-2 chimeric receptor.
Content And Storage
−20°C
Isotype
IgG
Applications
Immunoblot
Conjugate
Unconjugated
Host Species
Rabbit
Quantity
10 Tests
Primary or Secondary
Primary
Target Species
Mouse
Form
Purified
Related Products
Description
- Specifically detects PhosphoDetect™ VEGFR2 (pTyr 1054/1059 ) Clone: in Mouse samples, and it is validated for Immuno Blotting Vascular Endothelial Growth Factor Receptor 2 (VEGFR2) is receptor tyrosine kinase that serves as a key mediator in angiogenesis and plays an essential role in embryonic development, wound healing, cell proliferation, migration, and differentiation
- It contains seven immunoglobulin-like sequences in the extracellular domain and exhibits sequence similarity to Flt-1 (FMS-like tyrosine kinase 1) and Flt-4 (FMS-like tyrosine kinase 4)
- Upon binding to its ligand, VEGF, VEGFR2 undergoes ligand-induced dimerization, which activates its intrinsic tyrosine kinase activity resulting in auto- and trans-phosphorylation on specific tyrosine residues in the cytoplasmic domain
- These tyrosine residues, when phosphorylated, are involved as docking sites to recruit molecules containing Src homology 2 (SH2) or phosphotyrosine-binding domains and to convey signals to downstream effectors
- Phosphorylation of VEGFR2 at Tyr 1054 and Tyr 1059 within the activation loop is required for required for activation of VEGFR2 and enhances its intrinsic tyrosine kinase activity
- Phosphorylation at Tyr 1059 is also responsible for VEGF-induced intracellular Ca 2+ mobilization.
Compare Similar Items
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Antigen: PhosphoDetect™ VEGFR2 (pTyr1054/1059)
Classification: Polyclonal
Formulation: In Dulbecco's PBS (without Mg2+and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.3 (± 0.1).
Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1054/1059phosphorylation sites of mouse and human VEGFR-2
Regulatory Status: RUO
Test Specificity: Recognizes the ∽200kDa VEGFR-2 protein phosphorylated at Tyr1054/1059in porcine pancreatic cells transfected with a CSF-1/mouse VEGFR-2 chimeric receptor.
Content And Storage: −20°C
Isotype: IgG
Applications: Immunoblot
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 10 Tests
Primary or Secondary: Primary
Target Species: Mouse
Form: Purified
Antigen:
PhosphoDetect™ VEGFR2 (pTyr1054/1059)
Classification:
Polyclonal
Formulation:
In Dulbecco's PBS (without Mg2+and Ca2+), 1mg/mL BSA, 50% glycerol, pH 7.3 (± 0.1).
Immunogen:
a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1054/1059phosphorylation sites of mouse and human VEGFR-2
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽200kDa VEGFR-2 protein phosphorylated at Tyr1054/1059in porcine pancreatic cells transfected with a CSF-1/mouse VEGFR-2 chimeric receptor.
Content And Storage:
−20°C
Isotype:
IgG
Applications:
Immunoblot
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
10 Tests
Primary or Secondary:
Primary
Target Species:
Mouse
Form:
Purified
Antigen: PhosphoDetect™ JAK2 (pTyr1007/1008)
Classification: Polyclonal
Formulation: In Dulbecco's PBS (without Mg2+and Ca2+), 50 % glycerol, 1mg/mL BSA, pH 7.3 (± 0.1).
Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1007/1008phosphorylation sites of human JAK2
Regulatory Status: RUO
Test Specificity: Recognizes the ∽130kDa JAK2 protein phosphorylated at Tyr1007/1008in LIF-treated 3T3-L1 cells.
Content And Storage: −20°C
Isotype: IgG
Applications: Immunoblot
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human, Mouse, Rat
Form: Purified
Antigen:
PhosphoDetect™ JAK2 (pTyr1007/1008)
Classification:
Polyclonal
Formulation:
In Dulbecco's PBS (without Mg2+and Ca2+), 50 % glycerol, 1mg/mL BSA, pH 7.3 (± 0.1).
Immunogen:
a synthetic phosphopeptide corresponding to amino acids surrounding the Tyr1007/1008phosphorylation sites of human JAK2
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽130kDa JAK2 protein phosphorylated at Tyr1007/1008in LIF-treated 3T3-L1 cells.
Content And Storage:
−20°C
Isotype:
IgG
Applications:
Immunoblot
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human, Mouse, Rat
Form:
Purified
Antigen: PhosphoDetect™ Smad3 (pSer423/425)
Classification: Monoclonal
Formulation: In 150mM NaCl, 10mM HEPES, 100μg/ml BSA, 50% glycerol pH 7.5.
Immunogen: a synthetic phosphopeptide corresponding to amino acids surrounding the Ser423/425phosphorylation sites of Smad3, coupled to KLH.
Regulatory Status: RUO
Test Specificity: Recognizes the ∽52kDa Smad3 protein phosphorylated at Ser423/425in HT-1080 cells treated with TGF-β1.
Content And Storage: −20°C
Isotype: IgG
Applications: Immunoprecipitation
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 50 μL
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
PhosphoDetect™ Smad3 (pSer423/425)
Classification:
Monoclonal
Formulation:
In 150mM NaCl, 10mM HEPES, 100μg/ml BSA, 50% glycerol pH 7.5.
Immunogen:
a synthetic phosphopeptide corresponding to amino acids surrounding the Ser423/425phosphorylation sites of Smad3, coupled to KLH.
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽52kDa Smad3 protein phosphorylated at Ser423/425in HT-1080 cells treated with TGF-β1.
Content And Storage:
−20°C
Isotype:
IgG
Applications:
Immunoprecipitation
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
50 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified
Antigen: PhosphoDetect™ RhoA (pSer188)
Classification: Polyclonal
Formulation: In PBS, 1mg/mL BSA, 50% glycerol.
Immunogen: a synthetic peptide corresponding to amino acids surrounding the Ser188phosphorylation site of human RhoA, coupled to KLH
Regulatory Status: RUO
Test Specificity: Recognizes the ∽22kDa RhoA protein, expressed as a GST fusion protein (total ∽49kDa) and phosphorylatedin vitroby PKA.
Content And Storage: −20°C
Isotype: IgG
Applications: ELISA, Immunoblot, Immunoblot
Conjugate: Unconjugated
Host Species: Rabbit
Quantity: 100 μL
Primary or Secondary: Primary
Target Species: Human
Form: Purified
Antigen:
PhosphoDetect™ RhoA (pSer188)
Classification:
Polyclonal
Formulation:
In PBS, 1mg/mL BSA, 50% glycerol.
Immunogen:
a synthetic peptide corresponding to amino acids surrounding the Ser188phosphorylation site of human RhoA, coupled to KLH
Regulatory Status:
RUO
Test Specificity:
Recognizes the ∽22kDa RhoA protein, expressed as a GST fusion protein (total ∽49kDa) and phosphorylatedin vitroby PKA.
Content And Storage:
−20°C
Isotype:
IgG
Applications:
ELISA, Immunoblot, Immunoblot
Conjugate:
Unconjugated
Host Species:
Rabbit
Quantity:
100 μL
Primary or Secondary:
Primary
Target Species:
Human
Form:
Purified