MABN857

MilliporeSigma™ SYNE1, Mouse, Unlabeled, Clone: 200A6,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABN857-Each-of-1 In Stock ₹ 37,453.03

MABN857 - Each of 1

₹ 37,453.03

In Stock

Quantity

1

Base Price: ₹ 37,453.03

GST (18%): ₹ 6,741.545

Total Price: ₹ 44,194.575

Antigen

SYNE1

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.

Q6ZWR6;Q63128

Immunogen

Synthetic peptide corresponding to a sequence within the third coiled coil of rat spliced isoform CPG2 or the tenth Spectrin domain of mouse spliced isoform 1 (a.k.a. Enaptin or Nesprin-1 Giant).

Quantity

100 μg

Research Discipline

Neuroscience

Gene ID (Entrez)

NM_001079686;CAA64740

Target Species

Rat

Form

Purified

Applications

Immunocytochemistry, Western Blot

Clone

200A6

Conjugate

Unconjugated

Gene

Syne1, Cpg2, Myne1

Host Species

Mouse

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

Immunogen sequence is present in rat spliced isoform CPG2 (UniProt Q63128), as well as in mouse spliced isoform Enaptin (a.k.a. Nesprin-1 Giant), Syne-1B, and Enaptin-165 (UniProt Q6ZWR6). Target region is not found in rat isoform Nesprin-1 (UniProt Q8VHJ9), or in mouse isoform 2 and Syne-1A. Clone 200A6 detected shRNA-mediated knockdown of SYNE1 spliced isoform CPG2 in rat neurons by fluorescent immunocytochemistry and immunoblotting (Cottrell, J.R., et al. (2004). Neuron. 44(4):677-690).

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Isotype

IgG1 κ

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Description

  • Human SYNE1 gene (UniProt Q8NF91; Gene ID 23345) is among the top ten loci conferring risk for the five major psychiatric disorders, schizophrenia, bipolar disorder (BD), major depression, attention deficit-hyperactivity disorder (ADHD), and autism spectrum disorder (ASD), as well as multiple other neurological and neuromuscular disorders
  • The BD-associated single nucleotide polymorphisms (SNPs) are in a region of the human SYNE1 gene homologous to brain-specific transcripts of rat Syne1-encoding CPG2 (candidate plasticity gene 2; UniProt Q63128; Gene ID 499010), originally identified as an upregulated transcript during kainic acid-induced seizures in the rat dentate gyrus
  • The rat CPG2 spliced variant localizes to excitatory synapses of excitatory neurons, where it plays a role in synaptic plasticity and facilitates glutamate receptor cycling.

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MilliporeSigma™

MABN857

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Antigen:
SYNE1

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse IgG1 in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
Q6ZWR6;Q63128

Immunogen:
Synthetic peptide corresponding to a sequence within the third coiled coil of rat spliced isoform CPG2 or the tenth Spectrin domain of mouse spliced isoform 1 (a.k.a. Enaptin or Nesprin-1 Giant).

Quantity:
100 μg

Research Discipline:
Neuroscience

Gene ID (Entrez):
NM_001079686;CAA64740

Target Species:
Rat

Form:
Purified

Applications:
Immunocytochemistry, Western Blot

Clone:
200A6

Conjugate:
Unconjugated

Gene:
Syne1, Cpg2, Myne1

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Immunogen sequence is present in rat spliced isoform CPG2 (UniProt Q63128), as well as in mouse spliced isoform Enaptin (a.k.a. Nesprin-1 Giant), Syne-1B, and Enaptin-165 (UniProt Q6ZWR6). Target region is not found in rat isoform Nesprin-1 (UniProt Q8VHJ9), or in mouse isoform 2 and Syne-1A. Clone 200A6 detected shRNA-mediated knockdown of SYNE1 spliced isoform CPG2 in rat neurons by fluorescent immunocytochemistry and immunoblotting (Cottrell, J.R., et al. (2004). Neuron. 44(4):677-690).

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG1 κ

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MABN866MI

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Antigen:
Myocilin (NT)

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG1κ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
Q99972

Immunogen:
Recombinant protein corresponding to the N-terminal fragment (aa 33-214) of human Myocilin.

Quantity:
100 μg

Research Discipline:
Neuroscience

Gene ID (Entrez):
NP_000252

Target Species:
Human, Mouse

Form:
Purified

Applications:
Immunohistochemistry, Western Blot

Clone:
7.1

Conjugate:
__

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG1 κ

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MilliporeSigma™

MABN873MI

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Antigen:
Kallikrein 6/KLK6

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified mouse monoclonal IgG1κ antibody in 0.1M Sodium bicarbonate buffer, pH 8.2 with 0.02% Sodium Azide.

Gene Accession No.:
Q92876

Immunogen:
Recombinant full-length human Kallikrein 6.

Quantity:
100 μg

Research Discipline:
Neuroscience

Gene ID (Entrez):
NP_002765.1

Target Species:
Human

Form:
Purified

Applications:
ELISA, Immunohistochemistry (Paraffin), Inhibition Assays

Clone:
E24

Conjugate:
Unconjugated

Gene:
KLK6, PRSS18, PRSS9

Host Species:
Mouse

Purification Method:
__

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
Clone E24 reacts with kallikrein-6, but not other kallikrein family members. Reactivity against kallikrein-6 spliced isoforms 2&3 reported by UniProt (Q92876) has not been determined.

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG1 κ

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MABN875MI

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Antigen:
GABAA, γ2 subunit

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
P18507

Immunogen:
GST-tagged recombinant protein corresponding to the cytoplasmic domain of human GABAA γ2 Subunit.

Quantity:
100 μg

Research Discipline:
Neuroscience

Gene ID (Entrez):
NP_944494

Target Species:
Bovine, Human, Mouse, Rat

Form:
Purified

Applications:
ELISA, Immunohistochemistry (Paraffin), Immunoprecipitation, Western Blot

Clone:
KC4-8A7

Conjugate:
__

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG2a κ