MABE960MI

MilliporeSigma™ Fox1, Rat, Unlabeled, Clone: A2BP1,

Manufacturer: MilliporeSigma™

Select a Size

Pack Size SKU Availability Price
Each of 1 MABE960MI-Each-of-1 In Stock ₹ 37,453.03

MABE960MI - Each of 1

₹ 37,453.03

In Stock

Quantity

1

Base Price: ₹ 37,453.03

GST (18%): ₹ 6,741.545

Total Price: ₹ 44,194.575

Antigen

Fox1

Classification

Monoclonal

Concentration

Please refer to lot specific datasheet.

Formulation

Purified rat IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.

Q9NWB1

Immunogen

Recombinant full-length human Fox1.

Quantity

100 μg

Research Discipline

Epigenetics & Nuclear Function

Gene ID (Entrez)

NP_061193

Target Species

Human

Form

Purified

Applications

Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin)

Clone

A2BP1

Conjugate

Unconjugated

Gene

RBFOX1, A2BP, A2BP1, FOX1, HRNBP1

Host Species

Rat

Purification Method

Protein G Purified

Regulatory Status

RUO

Primary or Secondary

Primary

Test Specificity

This monoclonal antibody immunostained exclusively differentiated neurons, but not neural stem cells, neuronal progenitors, astrocytes, or oligodendrocytes derived from p53-/-Pten+/- murine premalignant neural/progenitor stem cell (M-NSC) cultures (Hu, J., et al. (2013). Proc. Natl. Acad. Sci. U.S.A. 110(36):14520-14527).

Content And Storage

Stable for 1 year at 2°-8°C from date of receipt.

Isotype

IgG2a κ

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Description

  • RNA binding protein fox-1 homolog 1 (UniProt Q9NWB1; also known as Ataxin-2-binding protein 1, Fox-1 homolog A, Hexaribonucleotide-binding protein 1) is encoded by the RBFOX1 (also known as A2BP, A2BP1, FOX1, HRNBP1) gene (Gene ID 54715) in human
  • The RNA-binding Fox (Rbfox) family of splicing factors is comprised of three members, Rbfox1 (Fox-1 or A2BP1), Rbfox2 (Fox-2 or RBM9), and Rbfox3 (Fox-3, HRNBP3 or NeuN)
  • Rbfox proteins regulate splicing of many neuronal transcripts (pre-mRNAs) by binding the sequence (U)GCAUG in introns flanking alternative exons
  • A (U)GCAUG motif that lies downstream of the alternative exon generally promotes Rbfox-dependent exon inclusion, whereas an upstream motif will usually repress exon inclusion
  • Rbfox1 transcript itself is subjected to alternative splicing in response to chronic cell depolarization, resulting in the increased expression of the nuclear, splicing-active Rbfox1 isoform, which in turn leading to increased splicing of Rbfox1 target transcripts of proteins, including N-methyl D-aspartate (NMDA) receptor 1 (Grin1) and a calcium ATPase (Atp2b1), that play important roles in neuronal excitation and calcium homeostasis.

Compare Similar Items

Show Difference

Img

MilliporeSigma™

MABE960MI

--


Antigen:
Fox1

Classification:
Monoclonal

Concentration:
Please refer to lot specific datasheet.

Formulation:
Purified rat IgG2aκ in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.

Gene Accession No.:
Q9NWB1

Immunogen:
Recombinant full-length human Fox1.

Quantity:
100 μg

Research Discipline:
Epigenetics & Nuclear Function

Gene ID (Entrez):
NP_061193

Target Species:
Human

Form:
Purified

Applications:
Immunofluorescence, Immunohistochemistry, Immunohistochemistry (Paraffin)

Clone:
A2BP1

Conjugate:
Unconjugated

Gene:
RBFOX1, A2BP, A2BP1, FOX1, HRNBP1

Host Species:
Rat

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
This monoclonal antibody immunostained exclusively differentiated neurons, but not neural stem cells, neuronal progenitors, astrocytes, or oligodendrocytes derived from p53-/-Pten+/- murine premalignant neural/progenitor stem cell (M-NSC) cultures (Hu, J., et al. (2013). Proc. Natl. Acad. Sci. U.S.A. 110(36):14520-14527).

Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.

Isotype:
IgG2a κ

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MABE966MI

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Antigen:
DNA polymerase II subunit A

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
Q07864

Immunogen:
GST-tagged recombinant protein corresponding to human DNA polymerase II subunit A near the N-terminus.

Quantity:
200 μg

Research Discipline:
Epigenetics and Nuclear Function

Gene ID (Entrez):
NP_006222

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
9F11.1

Conjugate:
__

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G Purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.

Isotype:
IgG2a κ

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MilliporeSigma™

MABE967MI

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Antigen:
DNA polymerase delta p125

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
P28340

Immunogen:
GST-tagged recombinant protein corresponding to the N-terminus of human DNA polymerase delta p125.

Quantity:
100 μg

Research Discipline:
Epigenetics, Nuclear Function

Gene ID (Entrez):
NP_001243778

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
11E10.1

Conjugate:
Unconjugated

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
2°C to 8°C for one year from date of shipment

Isotype:
IgG2b κ

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MABE968MI

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Antigen:
HLCS

Classification:
Monoclonal

Concentration:
__

Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.

Gene Accession No.:
P50747

Immunogen:
GST-tagged recombinant protein corresponding to the N-terminal region of human HLCS.

Quantity:
100 μg

Research Discipline:
Signaling

Gene ID (Entrez):
NP_000402

Target Species:
Human

Form:
Purified

Applications:
Western Blot

Clone:
2C2.1

Conjugate:
Unconjugated

Gene:
__

Host Species:
Mouse

Purification Method:
Protein G purified

Regulatory Status:
RUO

Primary or Secondary:
Primary

Test Specificity:
__

Content And Storage:
2°C to 8°C for one year from date of shipment

Isotype:
IgG2a κ