MABS1147MI
MilliporeSigma™ SH2D1A, Mouse, Unlabeled, Clone: SuGr-20 18A9,
Manufacturer: MilliporeSigma™
Select a Size
| Pack Size | SKU | Availability | Price |
|---|---|---|---|
| Each of 1 | MABS1147MI-Each-of-1 | In Stock | ₹ 38,734.72 |
MABS1147MI - Each of 1
In Stock
Quantity
1
Base Price: ₹ 38,734.72
GST (18%): ₹ 6,972.25
Total Price: ₹ 45,706.97
Antigen
SH2D1A
Classification
Monoclonal
Concentration
Please refer to lot specific datasheet.
Formulation
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.
O60880
Immunogen
Recombinant full-length human SH2D1A.
Quantity
100 μg
Research Discipline
Signaling
Gene ID (Entrez)
NP_002342
Target Species
Human
Form
Purified
Applications
Western Blot
Clone
SuGr-20 18A9
Conjugate
Unconjugated
Gene
SH2D1A, DSHP, SAP, XLP, XLP1, XLPD
Host Species
Mouse
Purification Method
Protein G Purified
Regulatory Status
RUO
Primary or Secondary
Primary
Test Specificity
Clone SuGr-20 18A9 recognizes recombinant full-length human SH2D1A spliced isoform A (UniProt O60880-1) by Western blotting. Reactivity toward spliced isoforms B to F (UniProt O60880-2 to O60880-6) has not been determined.
Content And Storage
Stable for 1 year at 2°-8°C from date of receipt.
Isotype
IgG2b κ
Related Products
Description
- SH2 domain-containing protein 1A (UniProt O60880; also known as Duncan disease SH2-protein, Signaling lymphocytic activation molecule-associated protein, SLAM-associated protein, T-cell signal transduction molecule SAP) is encoded by the SH2D1A (also known as DSHP, SAP, XLP, XLP1, XLPD) gene (Gene ID 4068) in human
- SAP/SH2D1A is a 628-amino acid (isoform A) adaptor protein expressed in T cells, natural killer (NK) cells, NK-T cells, and some B cells
- SAP/SH2D1A is made up almost exclusively of a Src homology 2 (SH2) domain (a.a
- 6-104) and plays an important role in multiple immune cell functions, including T helper 2 (TH2) cytokine production, T cell-dependent antibody production, follicular T helper (TFH) cell differentiation, NK-T cell development, CD8+ T cell- and NK cell-mediated cytotoxicity
- SAP couples signaling lymphocytic activation molecule (SLAM) family receptors to tyrosine phosphorylation signals through its interaction with the SH3 domain of Src family protein tyrosine kinase Fyn
- In addition, SAP can prevent SH2 domain-containing negative regulators, such as phosphatases SHIP-1 and SHP-1, from inactivating SLAM-related receptors by blocking their interaction with the receptors
- Evidence also shows that SAP/SH2D1A regulates T cell-dependent antibody production and TFH cell differentiation independent of Fyn
- SAP/SH2D1A gene is mutated and inactivated in X-linked lymphoproliferative disease, a rare human immunodeficiency characterized by an uncontrolled immune response to Epstein-Barr virus infection.
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Antigen: SH2D1A
Classification: Monoclonal
Concentration: Please refer to lot specific datasheet.
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.: O60880
Immunogen: Recombinant full-length human SH2D1A.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_002342
Target Species: Human
Form: Purified
Applications: Western Blot
Clone: SuGr-20 18A9
Conjugate: Unconjugated
Gene: SH2D1A, DSHP, SAP, XLP, XLP1, XLPD
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone SuGr-20 18A9 recognizes recombinant full-length human SH2D1A spliced isoform A (UniProt O60880-1) by Western blotting. Reactivity toward spliced isoforms B to F (UniProt O60880-2 to O60880-6) has not been determined.
Content And Storage: Stable for 1 year at 2°-8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
SH2D1A
Classification:
Monoclonal
Concentration:
Please refer to lot specific datasheet.
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% Sodium Azide.
Gene Accession No.:
O60880
Immunogen:
Recombinant full-length human SH2D1A.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_002342
Target Species:
Human
Form:
Purified
Applications:
Western Blot
Clone:
SuGr-20 18A9
Conjugate:
Unconjugated
Gene:
SH2D1A, DSHP, SAP, XLP, XLP1, XLPD
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone SuGr-20 18A9 recognizes recombinant full-length human SH2D1A spliced isoform A (UniProt O60880-1) by Western blotting. Reactivity toward spliced isoforms B to F (UniProt O60880-2 to O60880-6) has not been determined.
Content And Storage:
Stable for 1 year at 2°-8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: ROR2
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q9Z138
Immunogen: Recombinant protein corresponding to the second Ser/Thr-rich domain of mouse mRor2.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): __
Target Species: Human, Mouse
Form: Purified
Applications: ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone: Nt2535-2835
Conjugate: Unconjugated
Gene: __
Host Species: Mouse
Purification Method: Protein G purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: Clone Nt 2535-2835 is specific to the mouse and human ROR2, but does not detect mouse ROR1. Clone Nt 2535-2835 exclusively detects ROR2 protein in paraffin-embedded tissues (Mikels, A., et al. (2009). J. Biol. Chem. 284(44):30167-30176).
Content And Storage: 2°C to 8°C for one year from date of shipment
Isotype: IgG1 κ
Antigen:
ROR2
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG1κ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q9Z138
Immunogen:
Recombinant protein corresponding to the second Ser/Thr-rich domain of mouse mRor2.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
__
Target Species:
Human, Mouse
Form:
Purified
Applications:
ELISA, Immunohistochemistry, Immunohistochemistry (Paraffin), Western Blot
Clone:
Nt2535-2835
Conjugate:
Unconjugated
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
Clone Nt 2535-2835 is specific to the mouse and human ROR2, but does not detect mouse ROR1. Clone Nt 2535-2835 exclusively detects ROR2 protein in paraffin-embedded tissues (Mikels, A., et al. (2009). J. Biol. Chem. 284(44):30167-30176).
Content And Storage:
2°C to 8°C for one year from date of shipment
Isotype:
IgG1 κ
Antigen: Derlin-1
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: Q9BUN8
Immunogen: GST-tagged recombinant human derlin-1 C-terminal cytoplasmic fragment.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_001128143
Target Species: Human, Mouse
Form: Purified
Applications: Immunocytochemistry, Western Blot
Clone: 8G11.2
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2b κ
Antigen:
Derlin-1
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2bκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
Q9BUN8
Immunogen:
GST-tagged recombinant human derlin-1 C-terminal cytoplasmic fragment.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_001128143
Target Species:
Human, Mouse
Form:
Purified
Applications:
Immunocytochemistry, Western Blot
Clone:
8G11.2
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2b κ
Antigen: Fibrocystin
Classification: Monoclonal
Concentration: __
Formulation: Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.: P08F94
Immunogen: Recombinant protein corresponding to human Fibrocystin fragment from the N-terminal half.
Quantity: 100 μg
Research Discipline: Signaling
Gene ID (Entrez): NP_619639
Target Species: Human, Rat
Form: Purified
Applications: Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone: 18
Conjugate: __
Gene: __
Host Species: Mouse
Purification Method: Protein G Purified
Regulatory Status: RUO
Primary or Secondary: Primary
Test Specificity: __
Content And Storage: Stable for one year at 2°C to 8°C from date of receipt.
Isotype: IgG2a κ
Antigen:
Fibrocystin
Classification:
Monoclonal
Concentration:
__
Formulation:
Purified mouse monoclonal IgG2aκ antibody in buffer containing 0.1M Tris-Glycine (pH 7.4), 150mM NaCl with 0.05% sodium azide.
Gene Accession No.:
P08F94
Immunogen:
Recombinant protein corresponding to human Fibrocystin fragment from the N-terminal half.
Quantity:
100 μg
Research Discipline:
Signaling
Gene ID (Entrez):
NP_619639
Target Species:
Human, Rat
Form:
Purified
Applications:
Immunocytochemistry, Immunohistochemistry (Paraffin)
Clone:
18
Conjugate:
__
Gene:
__
Host Species:
Mouse
Purification Method:
Protein G Purified
Regulatory Status:
RUO
Primary or Secondary:
Primary
Test Specificity:
__
Content And Storage:
Stable for one year at 2°C to 8°C from date of receipt.
Isotype:
IgG2a κ